Detailed information NTG0420313

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: IB937_RS01170
• Genome accession: NZ_CP061132
• Coordinates: 213228..213968 (+)
• Length: 246 a.a.
• NCBI ID: WP_011528222.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain BSAC_bs1388 isolate Invasive disease
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 208228..218968

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IB937_RS01155 (IB937_01155)	gltX	208758..210203 (+)	1446	WP_002993289.1	glutamate--tRNA ligase	-
IB937_RS01160 (IB937_01160)	-	210598..211944 (+)	1347	WP_063815444.1	sensor histidine kinase	-
IB937_RS01165 (IB937_01165)	-	211941..213224 (+)	1284	WP_010921869.1	sensor histidine kinase	-
IB937_RS01170 (IB937_01170)	comE/blpR	213228..213968 (+)	741	WP_011528222.1	response regulator transcription factor	Regulator
IB937_RS01175 (IB937_01175)	rnpA	214508..214867 (+)	360	WP_002992035.1	ribonuclease P protein component	-
IB937_RS01180 (IB937_01180)	-	214833..215660 (+)	828	WP_011528223.1	YidC/Oxa1 family membrane protein insertase	-
IB937_RS01185 (IB937_01185)	jag	215672..216586 (+)	915	WP_011528224.1	RNA-binding cell elongation regulator Jag/EloR	-
IB937_RS01190 (IB937_01190)	rpmH	216900..217034 (+)	135	WP_002885866.1	50S ribosomal protein L34	-
IB937_RS01195 (IB937_01195)	-	217309..218013 (+)	705	WP_011528225.1	N-acetylmannosamine-6-phosphate 2-epimerase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28909.53 Da
• Isoelectric Point: 6.8298

>NTDB_id=420313 IB937_RS01170 WP_011528222.1 213228..213968(+) (comE/blpR) [Streptococcus pyogenes strain BSAC_bs1388 isolate Invasive disease]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTRTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=420313 IB937_RS01170 WP_011528222.1 213228..213968(+) (comE/blpR) [Streptococcus pyogenes strain BSAC_bs1388 isolate Invasive disease]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCCGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCGGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGCAGTGGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGATTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCTCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.903	100	0.382
comE/comE2	Streptococcus gordonii strain NCTC7865	37.903	100	0.382
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37