Detailed information NTG0404926

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: GOM48_RS06220
• Genome accession: NZ_CP046523
• Coordinates: 1226006..1226656 (-)
• Length: 216 a.a.
• NCBI ID: WP_235096463.1
• Uniprot ID: -
• Organism: Streptococcus oralis strain SOD
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1221006..1231656

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GOM48_RS06200 (GOM48_06195)	-	1221600..1222784 (-)	1185	WP_235096460.1	hypothetical protein	-
GOM48_RS06205 (GOM48_06200)	-	1222781..1223374 (-)	594	WP_235096461.1	ATP-binding cassette domain-containing protein	-
GOM48_RS06210	-	1223407..1223595 (-)	189	WP_235098753.1	hypothetical protein	-
GOM48_RS06215 (GOM48_06205)	comEC/celB	1223782..1226022 (-)	2241	WP_235096462.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
GOM48_RS06220 (GOM48_06210)	comEA/celA/cilE	1226006..1226656 (-)	651	WP_235096463.1	helix-hairpin-helix domain-containing protein	Machinery gene
GOM48_RS06225 (GOM48_06215)	-	1226723..1227292 (-)	570	WP_235096464.1	GNAT family N-acetyltransferase	-
GOM48_RS06230 (GOM48_06220)	ald	1227469..1228581 (+)	1113	WP_235096465.1	alanine dehydrogenase	-
GOM48_RS06235 (GOM48_06225)	-	1228644..1229630 (-)	987	WP_235096466.1	PhoH family protein	-
GOM48_RS06240 (GOM48_06230)	-	1229711..1229926 (-)	216	WP_001232084.1	YozE family protein	-
GOM48_RS06245 (GOM48_06235)	-	1229923..1230528 (-)	606	WP_235096467.1	GrpB family protein	-
GOM48_RS06250 (GOM48_06240)	cvfB	1230540..1231394 (-)	855	WP_125399164.1	RNA-binding virulence regulatory protein CvfB	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23272.46 Da
• Isoelectric Point: 6.5108

>NTDB_id=404926 GOM48_RS06220 WP_235096463.1 1226006..1226656(-) (comEA/celA/cilE) [Streptococcus oralis strain SOD]
MEAIIEKIKEYKIIVICAGLGLALGGFFLLKPTSQTPVKETNLQTEVAAVSKDSSSEKEVKKEEKEESPEQDLITVDVKG
AVKSPGIYDLPLGSRVHDAVQKAGGLTEEADSKSLNLAQKVSDEALVYVPTKGEEAASQQAASGTSSSTSKDKKVNLNKA
SLEELKQVKGLGRKRAQDIIDHREANGKFKSVDELKKVSGIGTKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=404926 GOM48_RS06220 WP_235096463.1 1226006..1226656(-) (comEA/celA/cilE) [Streptococcus oralis strain SOD]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATTGTTATCTGTGCTGGTTTGGGTTTGGCCCTCGGCGGATT
TTTCCTACTAAAGCCAACTTCACAAACACCCGTCAAAGAAACAAATTTGCAGACTGAAGTCGCAGCTGTTTCAAAGGATT
CATCGTCTGAAAAGGAAGTCAAGAAGGAAGAAAAGGAAGAATCTCCTGAGCAAGATTTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCACCAGGGATTTATGACTTGCCTCTTGGCAGTCGAGTTCACGATGCCGTTCAGAAGGCAGGTGGATTGAC
AGAGGAGGCAGATAGCAAGTCGCTCAATCTAGCTCAGAAAGTCAGTGACGAGGCTCTTGTCTATGTTCCAACTAAGGGAG
AAGAAGCAGCTAGTCAGCAGGCCGCCTCTGGAACGTCTTCTTCTACAAGTAAAGATAAGAAAGTCAACCTCAATAAGGCC
AGTCTGGAAGAACTCAAACAGGTCAAAGGATTGGGCAGAAAAAGAGCTCAGGATATTATTGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGATGAACTCAAGAAAGTATCTGGCATTGGCACAAAGACCATAGAAAAGCTAAAAGATTATGTCA
CAGTGGACTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (76-126)

• Helix-hairpin-helix motif (HHH_3) (152-214)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	91.204	100	0.912
comEA/celA/cilE	Streptococcus mitis NCTC 12261	91.204	100	0.912
comEA/celA/cilE	Streptococcus pneumoniae Rx1	89.352	100	0.894
comEA/celA/cilE	Streptococcus pneumoniae D39	89.352	100	0.894
comEA/celA/cilE	Streptococcus pneumoniae R6	89.352	100	0.894
comEA/celA/cilE	Streptococcus mitis SK321	87.5	100	0.875
comEA	Lactococcus lactis subsp. cremoris KW2	41.441	100	0.426
comEA	Streptococcus thermophilus LMD-9	38.696	100	0.412
comEA	Latilactobacillus sakei subsp. sakei 23K	33.906	100	0.366
comEA	Bacillus subtilis subsp. subtilis str. 168	41.053	87.963	0.361