Detailed information NTG0404892

Bioinformatically predicted

Overview

• Name: comGF/cglF
• Type: Machinery gene
• Locus tag: GOM48_RS00950
• Genome accession: NZ_CP046523
• Coordinates: 185082..185543 (+)
• Length: 153 a.a.
• NCBI ID: WP_002875275.1
• Uniprot ID: A0A1X1HB00
• Organism: Streptococcus oralis strain SOD
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 180082..190543

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GOM48_RS00915 (GOM48_00900)	nagA	180500..181651 (+)	1152	WP_084945412.1	N-acetylglucosamine-6-phosphate deacetylase	-
GOM48_RS00920 (GOM48_00905)	-	181800..182165 (+)	366	WP_000286399.1	DUF1033 family protein	-
GOM48_RS00925 (GOM48_00910)	comGA/cglA/cilD	182227..183168 (+)	942	WP_235097792.1	competence type IV pilus ATPase ComGA	Machinery gene
GOM48_RS00930 (GOM48_00915)	comGB/cglB	183116..184132 (+)	1017	WP_235097794.1	competence type IV pilus assembly protein ComGB	Machinery gene
GOM48_RS00935 (GOM48_00920)	comGC/cglC	184134..184457 (+)	324	WP_235097796.1	competence type IV pilus major pilin ComGC	Machinery gene
GOM48_RS00940 (GOM48_00925)	comGD/cglD	184420..184854 (+)	435	WP_235097798.1	competence type IV pilus minor pilin ComGD	Machinery gene
GOM48_RS00945 (GOM48_00930)	comGE/cglE	184817..185119 (+)	303	WP_235097800.1	competence type IV pilus minor pilin ComGE	Machinery gene
GOM48_RS00950 (GOM48_00935)	comGF/cglF	185082..185543 (+)	462	WP_002875275.1	competence type IV pilus minor pilin ComGF	Machinery gene
GOM48_RS00955 (GOM48_00940)	comGG/cglG	185521..185934 (+)	414	WP_235097802.1	competence type IV pilus minor pilin ComGG	Machinery gene
GOM48_RS00960 (GOM48_00945)	-	185967..186557 (+)	591	WP_235097805.1	class I SAM-dependent methyltransferase	-
GOM48_RS00965 (GOM48_00950)	comYH	186616..187569 (+)	954	WP_235097806.1	class I SAM-dependent methyltransferase	Machinery gene
GOM48_RS00970 (GOM48_00955)	-	187619..188809 (+)	1191	WP_235097808.1	acetate kinase	-
GOM48_RS00975 (GOM48_00960)	rnpA	188958..189329 (+)	372	WP_000748124.1	ribonuclease P protein component	-
GOM48_RS00980 (GOM48_00965)	-	189304..190116 (+)	813	WP_235097810.1	YidC/Oxa1 family membrane protein insertase	-

Sequence

Protein

• Length: 153 a.a.
• Molecular weight: 17787.41 Da
• Isoelectric Point: 9.6234

>NTDB_id=404892 GOM48_RS00950 WP_002875275.1 185082..185543(+) (comGF/cglF) [Streptococcus oralis strain SOD]
MVQRSCSTLKSSKVRAFTLLESLIALIVISGGLLLFQAMSQLLISEVRYQQQSEQKEWLLFVDQLEAELERSQFEKVEGN
RLYLKQDGKDISIGKSKSDDFRKTDTSGRGYQPMVYGLKSAQITEENQLVRFRFQFQKGLEREFIYRVEKTKS

Nucleotide

• Length: 462 bp

>NTDB_id=404892 GOM48_RS00950 WP_002875275.1 185082..185543(+) (comGF/cglF) [Streptococcus oralis strain SOD]
ATGGTTCAGAGAAGTTGCTCGACCTTAAAGAGCAGTAAGGTAAGAGCGTTCACTCTATTAGAATCTCTGATTGCCCTTAT
CGTCATTAGCGGAGGTTTGCTCCTTTTTCAAGCTATGAGTCAGCTCCTCATTTCAGAAGTTCGTTACCAGCAGCAAAGTG
AGCAAAAGGAGTGGCTCTTGTTTGTGGATCAACTGGAGGCAGAGTTAGAGCGTTCGCAGTTTGAAAAGGTAGAAGGCAAT
CGCCTCTATTTAAAACAAGATGGTAAGGATATCTCTATAGGGAAGTCTAAATCGGATGATTTTCGAAAAACGGATACCAG
CGGACGGGGCTATCAGCCGATGGTTTATGGCCTCAAATCAGCTCAAATTACAGAGGAAAATCAATTGGTTCGCTTTCGTT
TCCAATTTCAAAAGGGCTTAGAAAGGGAGTTCATCTATCGTGTGGAAAAAACAAAAAGTTAA

Domains

Predicted by InterproScan.

• Putative Competence protein ComGF (ComGF) (45-141)

3D structure

• AlphaFold DB: A0A1X1HB00

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGF/cglF	Streptococcus mitis SK321	90.196	100	0.902
comGF/cglF	Streptococcus mitis NCTC 12261	88.889	100	0.889
comGF/cglF	Streptococcus pneumoniae Rx1	87.582	100	0.876
comGF/cglF	Streptococcus pneumoniae D39	87.582	100	0.876
comGF/cglF	Streptococcus pneumoniae R6	87.582	100	0.876
comGF/cglF	Streptococcus pneumoniae TIGR4	87.582	100	0.876
comGF	Lactococcus lactis subsp. cremoris KW2	41.429	91.503	0.379