Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   GL185_RS03125 Genome accession   NZ_CP046357
Coordinates   626706..627356 (-) Length   216 a.a.
NCBI ID   WP_094314335.1    Uniprot ID   A0AA44MWP3
Organism   Streptococcus pneumoniae strain 525     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 621706..632356
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GL185_RS03105 (GL185_03135) - 622308..623492 (-) 1185 WP_083979551.1 hypothetical protein -
  GL185_RS03110 (GL185_03140) - 623496..624083 (-) 588 WP_000933542.1 ABC transporter ATP-binding protein -
  GL185_RS03115 (GL185_03145) - 624115..624303 (-) 189 WP_001809102.1 hypothetical protein -
  GL185_RS03120 (GL185_03150) comEC/celB 624482..626722 (-) 2241 WP_044727637.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  GL185_RS03125 (GL185_03155) comEA/celA/cilE 626706..627356 (-) 651 WP_094314335.1 ComEA family DNA-binding protein Machinery gene
  GL185_RS03130 (GL185_03160) - 627424..627993 (-) 570 WP_114880827.1 GNAT family N-acetyltransferase -
  GL185_RS11010 ald 628170..629281 (+) 1112 Protein_627 alanine dehydrogenase -
  GL185_RS03150 (GL185_03180) - 629582..629907 (-) 326 Protein_628 TfoX/Sxy family protein -
  GL185_RS03155 (GL185_03185) - 629910..630410 (-) 501 WP_000566982.1 GNAT family N-acetyltransferase -
  GL185_RS03165 (GL185_03195) - 630603..631571 (-) 969 WP_000658183.1 PhoH family protein -
  GL185_RS03170 (GL185_03200) - 631657..631872 (-) 216 WP_001232082.1 YozE family protein -

Sequence

Protein


Download         Length: 216 a.a.        Molecular weight: 23175.51 Da        Isoelectric Point: 5.5171

>NTDB_id=403160 GL185_RS03125 WP_094314335.1 626706..627356(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain 525]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNVQAEVAAVSKDLVSEKEVNKEEKEEPVEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide


Download         Length: 651 bp        

>NTDB_id=403160 GL185_RS03125 WP_094314335.1 626706..627356(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain 525]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACACCTGTAAAGGAAACGAATGTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCAGTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

SLBB domain (SLBB)

(76-126)

Helix-hairpin-helix motif (HHH_3)

(151-214)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae Rx1

98.611

100

0.986
  comEA/celA/cilE Streptococcus pneumoniae D39

98.611

100

0.986
  comEA/celA/cilE Streptococcus pneumoniae R6

98.611

100

0.986
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

96.759

100

0.968
  comEA/celA/cilE Streptococcus mitis NCTC 12261

95.37

100

0.954
  comEA/celA/cilE Streptococcus mitis SK321

90.741

100

0.907
  comEA Lactococcus lactis subsp. cremoris KW2

43.612

100

0.458
  comEA Streptococcus thermophilus LMD-9

40.175

100

0.426
  comEA Bacillus subtilis subsp. subtilis str. 168

41.579

87.963

0.366
  comEA Latilactobacillus sakei subsp. sakei 23K

33.476

100

0.361

Multiple sequence alignment