Detailed information NTG0040044

Bioinformatically predicted

Overview

• Name: comEA
• Type: Machinery gene
• Locus tag: SGGBAA2069_RS03375
• Genome accession: NC_015215
• Coordinates: 638993..639658 (+)
• Length: 221 a.a.
• NCBI ID: WP_013642858.1
• Uniprot ID: A0A1I7F217
• Organism: Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 633993..644658

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SGGBAA2069_RS03355 (SGGBAA2069_c06010)	-	635424..637004 (+)	1581	WP_013642855.1	DEAD/DEAH box helicase	-
SGGBAA2069_RS03360 (SGGBAA2069_c06020)	-	637048..637311 (-)	264	WP_305727931.1	GIY-YIG nuclease family protein	-
SGGBAA2069_RS03365 (SGGBAA2069_c06030)	-	637295..638044 (-)	750	WP_013642857.1	tRNA1(Val) (adenine(37)-N6)-methyltransferase	-
SGGBAA2069_RS03370 (SGGBAA2069_c06040)	-	638152..638898 (+)	747	WP_009853766.1	lysophospholipid acyltransferase family protein	-
SGGBAA2069_RS03375 (SGGBAA2069_c06050)	comEA	638993..639658 (+)	666	WP_013642858.1	helix-hairpin-helix domain-containing protein	Machinery gene
SGGBAA2069_RS03380 (SGGBAA2069_c06060)	comEC/celB	639651..641882 (+)	2232	WP_014619988.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
SGGBAA2069_RS03385 (SGGBAA2069_c06070)	-	641944..642132 (+)	189	WP_013642860.1	type II toxin-antitoxin system HicA family toxin	-
SGGBAA2069_RS03390 (SGGBAA2069_c06080)	-	642172..642549 (+)	378	WP_013642861.1	type II toxin-antitoxin system HicB family antitoxin	-
SGGBAA2069_RS03395 (SGGBAA2069_c06090)	-	642633..643211 (+)	579	WP_013642862.1	HD domain-containing protein	-
SGGBAA2069_RS03400 (SGGBAA2069_c06100)	-	643214..643750 (+)	537	WP_231844605.1	hypothetical protein	-
SGGBAA2069_RS12115 (SGGBAA2069_c06110)	-	643792..643944 (+)	153	WP_013642864.1	hypothetical protein	-

Sequence

Protein

• Length: 221 a.a.
• Molecular weight: 23461.14 Da
• Isoelectric Point: 4.3235

>NTDB_id=40044 SGGBAA2069_RS03375 WP_013642858.1 638993..639658(+) (comEA) [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
MIEEIKEKLLENKTLVAVLGTILVMLIGFFAWSNVTKTTVDAQSDLPALSTTFSASSSASDLKTERSSSQTETQKVFVDI
KGAVKNEGVYELSSGSRVTDVVKLAGGFTEDADKKSVNLAEKVTDEAVIYVARVGENVAPTTTNSQANGSAQQEESSDKI
NLNTATLAELQTISGIGAKRAQDIIDYRDANGGFSSVDDLANVSGIGEKTLEKLKSEVTVD

Nucleotide

• Length: 666 bp

>NTDB_id=40044 SGGBAA2069_RS03375 WP_013642858.1 638993..639658(+) (comEA) [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
ATGATTGAAGAAATAAAAGAAAAACTTTTGGAGAACAAAACGTTGGTAGCGGTGTTGGGAACAATACTTGTTATGTTAAT
CGGATTTTTTGCTTGGTCAAATGTGACAAAAACAACAGTGGATGCGCAAAGTGACCTACCTGCCCTAAGCACGACTTTTT
CGGCAAGTAGCAGCGCAAGTGATTTAAAAACAGAACGTTCAAGTTCGCAAACTGAAACTCAAAAAGTGTTTGTAGATATC
AAAGGCGCTGTGAAAAATGAGGGTGTTTATGAGCTTTCAAGCGGTAGCCGTGTGACAGATGTGGTCAAATTAGCAGGTGG
TTTTACAGAAGATGCTGATAAGAAGTCGGTGAATTTGGCTGAAAAAGTAACCGATGAAGCGGTGATTTATGTGGCAAGAG
TTGGTGAAAATGTTGCTCCTACAACGACTAATTCACAAGCAAATGGCAGCGCTCAACAGGAAGAAAGTTCAGATAAAATC
AATCTTAATACCGCAACTTTGGCGGAACTCCAGACGATTTCTGGCATTGGCGCCAAACGTGCCCAAGACATTATTGACTA
CCGTGATGCCAATGGTGGTTTTTCATCAGTTGATGACTTGGCGAATGTGTCTGGTATCGGAGAAAAAACACTAGAAAAGC
TAAAATCTGAGGTGACCGTTGATTAA

Domains

Predicted by InterproScan.

• Helix-hairpin-helix motif (HHH_3) (157-219)

• SLBB domain (SLBB) (78-131)

3D structure

• AlphaFold DB: A0A1I7F217

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA	Streptococcus thermophilus LMD-9	48.498	100	0.511
comEA/celA/cilE	Streptococcus mitis SK321	47.964	100	0.48
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	47.085	100	0.475
comEA/celA/cilE	Streptococcus pneumoniae Rx1	45.74	100	0.462
comEA/celA/cilE	Streptococcus pneumoniae D39	45.74	100	0.462
comEA/celA/cilE	Streptococcus pneumoniae R6	45.74	100	0.462
comEA/celA/cilE	Streptococcus mitis NCTC 12261	45.291	100	0.457
comEA	Latilactobacillus sakei subsp. sakei 23K	37.443	99.095	0.371
comEA	Staphylococcus aureus MW2	36.364	99.548	0.362