Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA   Type   Machinery gene
Locus tag   FOC71_RS00745 Genome accession   NZ_CP053999
Coordinates   144442..145383 (-) Length   313 a.a.
NCBI ID   WP_003073980.1    Uniprot ID   T1ZH09
Organism   Streptococcus intermedius strain FDAARGOS_769     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 139442..150383
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FOC71_RS00705 (FOC71_00705) - 139493..140692 (-) 1200 WP_003073996.1 acetate kinase -
  FOC71_RS00710 (FOC71_00710) comGH 140739..141692 (-) 954 WP_003073994.1 class I SAM-dependent methyltransferase Machinery gene
  FOC71_RS00715 (FOC71_00715) comGG/cglG 141783..142109 (-) 327 WP_268928556.1 competence type IV pilus minor pilin ComGG Machinery gene
  FOC71_RS00720 (FOC71_00720) comGF/cglF 142090..142527 (-) 438 WP_003073990.1 competence type IV pilus minor pilin ComGF Machinery gene
  FOC71_RS00725 (FOC71_00725) comGE/cglE 142511..142804 (-) 294 WP_003073987.1 competence type IV pilus minor pilin ComGE Machinery gene
  FOC71_RS00730 (FOC71_00730) comGD 142776..143174 (-) 399 WP_260469249.1 competence type IV pilus minor pilin ComGD Machinery gene
  FOC71_RS00735 (FOC71_00735) comGC 143164..143481 (-) 318 WP_003073983.1 competence type IV pilus major pilin ComGC Machinery gene
  FOC71_RS00740 (FOC71_00740) comGB 143478..144500 (-) 1023 WP_172851983.1 competence type IV pilus assembly protein ComGB Machinery gene
  FOC71_RS00745 (FOC71_00745) comGA 144442..145383 (-) 942 WP_003073980.1 competence type IV pilus ATPase ComGA Machinery gene
  FOC71_RS00750 (FOC71_00750) - 145452..145817 (-) 366 WP_003073978.1 DUF1033 family protein -
  FOC71_RS00755 (FOC71_00755) glnA 146005..147351 (-) 1347 WP_003073975.1 type I glutamate--ammonia ligase -
  FOC71_RS00760 (FOC71_00760) - 147390..147749 (-) 360 WP_003073972.1 MerR family transcriptional regulator -
  FOC71_RS00765 (FOC71_00765) - 147826..148356 (-) 531 WP_003073971.1 aromatic acid exporter family protein -
  FOC71_RS00770 (FOC71_00770) - 148531..149211 (-) 681 WP_003073969.1 CHAP domain-containing protein -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 36048.41 Da        Isoelectric Point: 7.8529

>NTDB_id=396975 FOC71_RS00745 WP_003073980.1 144442..145383(-) (comGA) [Streptococcus intermedius strain FDAARGOS_769]
MVQNIAQDIICQAKEKQAQDIYFIPKENSYELYMRIGDERRFIQQYAFEKMAAVISHFKFTAGMNVGEKRRSQLGSCDYQ
YRDKKTSLRLSTVGDYRGYESLVIRLLHDEKAELKFWFAQIPELKGRLKQRGLYLFSGPVGSGKTTLMHQLAQERFADEQ
IMSIEDPVEIKQDRMLQLQLNEAIGLTYESLIKLSLRHRPDLLIIGEIRDTETARAVVRASLTGVTVFSTIHAKSVRGVY
ERLLELGVTEAELKIVLQGICYQRLIAKGGIVDFVSERYQEHDPSEWNRQIDQLYAAGHINLEQAKAEKIIHS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=396975 FOC71_RS00745 WP_003073980.1 144442..145383(-) (comGA) [Streptococcus intermedius strain FDAARGOS_769]
ATGGTTCAAAACATTGCACAAGATATTATTTGCCAAGCTAAGGAAAAACAGGCTCAAGATATTTATTTTATCCCAAAGGA
AAATAGTTATGAACTGTACATGAGAATTGGTGATGAGCGACGTTTTATACAACAGTATGCATTTGAAAAGATGGCAGCGG
TGATTAGTCATTTCAAATTTACTGCTGGGATGAATGTTGGTGAAAAACGTAGAAGCCAACTAGGGTCTTGTGATTATCAA
TACAGGGATAAGAAAACGTCACTGCGGTTGTCAACAGTAGGGGATTATCGCGGATATGAAAGTCTTGTGATTCGTTTATT
GCATGATGAAAAAGCAGAGTTGAAGTTTTGGTTTGCTCAAATTCCAGAGTTGAAAGGACGACTCAAGCAACGTGGACTTT
ATCTTTTTTCAGGACCGGTAGGGAGTGGCAAAACCACTCTTATGCATCAGCTGGCTCAAGAACGTTTTGCCGATGAGCAA
ATCATGTCTATCGAAGATCCTGTTGAAATTAAGCAAGACAGAATGTTGCAATTGCAATTGAATGAAGCGATTGGCTTAAC
TTATGAAAGTTTGATTAAACTTTCTCTTCGACATCGTCCAGATTTATTGATTATTGGAGAAATTCGAGATACAGAAACAG
CACGGGCGGTTGTACGAGCCAGCTTGACAGGAGTGACGGTCTTTTCAACGATTCATGCTAAAAGTGTGCGAGGCGTTTAT
GAACGATTGCTAGAGTTGGGAGTGACAGAAGCAGAGCTGAAAATTGTCTTGCAAGGTATTTGTTACCAACGGTTAATTGC
GAAAGGAGGAATAGTAGATTTTGTCAGTGAAAGGTATCAAGAACACGATCCAAGCGAATGGAATAGGCAAATTGATCAAC
TTTATGCAGCAGGACATATCAATCTTGAACAGGCAAAAGCGGAAAAAATTATCCACAGTTAA

Domains

Predicted by InterProScan.

Type II/IV secretion system protein (T2SSE)

(9-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB T1ZH09

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA Streptococcus gordonii str. Challis substr. CH1

80.645

99.042

0.799
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

75.08

100

0.751
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

74.76

100

0.748
  comGA/cglA/cilD Streptococcus pneumoniae D39

74.76

100

0.748
  comGA/cglA/cilD Streptococcus pneumoniae R6

74.76

100

0.748
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

74.76

100

0.748
  comGA Streptococcus mutans UA159

65.595

99.361

0.652
  comGA Streptococcus mutans UA140

65.595

99.361

0.652
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

63.226

99.042

0.626
  comGA Lactococcus lactis subsp. cremoris KW2

54.341

99.361

0.54
  comGA Latilactobacillus sakei subsp. sakei 23K

43.678

83.387

0.364

Multiple sequence alignment