Detailed information
Bioinformatically predicted
Overview
| Name | stkP/pknB | Type | Regulator |
| Locus tag | GFB63_RS01255 | Genome accession | NZ_CP045596 |
| Coordinates | 260687..262558 (-) | Length | 623 a.a. |
| NCBI ID | WP_084826071.1 | Uniprot ID | A0A0E2Q2K5 |
| Organism | Streptococcus thermophilus strain TK-P3A | ||
| Function | activate comX expression (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 258924..325359 | 260687..262558 | within | 0 |
Gene organization within MGE regions
Location: 258924..325359
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GFB63_RS01245 (GFB63_01300) | liaF | 258932..259630 (-) | 699 | WP_014621793.1 | cell wall-active antibiotics response protein LiaF | - |
| GFB63_RS10400 | - | 259885..260052 (-) | 168 | WP_228024402.1 | potassium channel family protein | - |
| GFB63_RS01255 (GFB63_01310) | stkP/pknB | 260687..262558 (-) | 1872 | WP_084826071.1 | Stk1 family PASTA domain-containing Ser/Thr kinase | Regulator |
| GFB63_RS01260 (GFB63_01315) | - | 262558..263295 (-) | 738 | WP_014727615.1 | Stp1/IreP family PP2C-type Ser/Thr phosphatase | - |
| GFB63_RS01265 (GFB63_01320) | rsmB | 263339..264661 (-) | 1323 | WP_193838341.1 | 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB | - |
| GFB63_RS01270 (GFB63_01325) | fmt | 264651..265586 (-) | 936 | WP_084828976.1 | methionyl-tRNA formyltransferase | - |
| GFB63_RS01275 (GFB63_01330) | - | 265604..268000 (-) | 2397 | WP_179971420.1 | primosomal protein N' | - |
| GFB63_RS01280 (GFB63_01335) | rpoZ | 268143..268457 (-) | 315 | WP_084828978.1 | DNA-directed RNA polymerase subunit omega | - |
| GFB63_RS01285 (GFB63_01340) | gmk | 268479..269108 (-) | 630 | WP_002951416.1 | guanylate kinase | - |
| GFB63_RS01290 (GFB63_01345) | ftsY | 269341..270732 (-) | 1392 | WP_193838342.1 | signal recognition particle-docking protein FtsY | - |
| GFB63_RS01295 (GFB63_01350) | - | 270746..271561 (-) | 816 | WP_024010001.1 | Cof-type HAD-IIB family hydrolase | - |
| GFB63_RS01300 (GFB63_01355) | - | 271554..272348 (-) | 795 | WP_011681412.1 | HAD-IIB family hydrolase | - |
| GFB63_RS01305 (GFB63_01360) | - | 272533..272910 (+) | 378 | WP_011681413.1 | GntR family transcriptional regulator | - |
| GFB63_RS01310 (GFB63_01365) | - | 272915..273613 (+) | 699 | WP_193838343.1 | ABC transporter ATP-binding protein | - |
| GFB63_RS01315 (GFB63_01370) | - | 273625..274410 (+) | 786 | WP_011681414.1 | hypothetical protein | - |
| GFB63_RS01320 (GFB63_01375) | amiF | 274460..275389 (-) | 930 | WP_193838344.1 | ATP-binding cassette domain-containing protein | Regulator |
| GFB63_RS01325 (GFB63_01380) | amiE | 275382..276467 (-) | 1086 | WP_011226304.1 | ABC transporter ATP-binding protein | Regulator |
| GFB63_RS01330 (GFB63_01385) | amiD | 276477..277403 (-) | 927 | WP_084828982.1 | oligopeptide ABC transporter permease OppC | Regulator |
| GFB63_RS01335 (GFB63_01390) | amiC | 277403..278896 (-) | 1494 | WP_024010009.1 | ABC transporter permease | Regulator |
| GFB63_RS01340 (GFB63_01395) | amiA3 | 278962..280932 (-) | 1971 | WP_193838345.1 | peptide ABC transporter substrate-binding protein | Regulator |
| GFB63_RS01345 (GFB63_01400) | - | 281169..281359 (-) | 191 | Protein_279 | IS3 family transposase | - |
| GFB63_RS10405 | - | 281353..281763 (-) | 411 | Protein_280 | ATP-binding cassette domain-containing protein | - |
| GFB63_RS01360 (GFB63_01415) | - | 281795..282109 (-) | 315 | Protein_281 | TatD family hydrolase | - |
| GFB63_RS01365 (GFB63_01420) | - | 282456..283649 (+) | 1194 | WP_100262689.1 | OFA family MFS transporter | - |
| GFB63_RS01370 (GFB63_01425) | - | 283709..285060 (-) | 1352 | Protein_283 | IS3 family transposase | - |
| GFB63_RS01375 (GFB63_01430) | pta | 285149..286132 (-) | 984 | WP_084828984.1 | phosphate acetyltransferase | - |
| GFB63_RS01380 (GFB63_01435) | - | 286146..287042 (-) | 897 | WP_100273464.1 | RluA family pseudouridine synthase | - |
| GFB63_RS01385 (GFB63_01440) | - | 287039..287875 (-) | 837 | WP_082245815.1 | NAD kinase | - |
| GFB63_RS01390 (GFB63_01445) | - | 287847..288521 (-) | 675 | WP_049554140.1 | GTP pyrophosphokinase family protein | - |
| GFB63_RS01395 (GFB63_01450) | - | 288617..289192 (+) | 576 | WP_002951444.1 | CYTH domain-containing protein | - |
| GFB63_RS01400 (GFB63_01455) | - | 289555..290526 (+) | 972 | WP_011681428.1 | ribose-phosphate diphosphokinase | - |
| GFB63_RS01405 (GFB63_01460) | - | 290530..291642 (+) | 1113 | WP_002948029.1 | cysteine desulfurase family protein | - |
| GFB63_RS01410 (GFB63_01465) | - | 291644..291991 (+) | 348 | WP_084826082.1 | DUF1831 domain-containing protein | - |
| GFB63_RS01415 (GFB63_01470) | - | 292135..292794 (+) | 660 | WP_084828989.1 | redox-sensing transcriptional repressor Rex | - |
| GFB63_RS01420 (GFB63_01475) | - | 292787..293482 (+) | 696 | WP_179972096.1 | gamma-glutamyl-gamma-aminobutyrate hydrolase family protein | - |
| GFB63_RS01425 (GFB63_01480) | radC | 293535..294221 (-) | 687 | WP_176243207.1 | RadC family protein | - |
| GFB63_RS01430 (GFB63_01485) | - | 294271..296055 (-) | 1785 | WP_084828992.1 | rhamnan synthesis F family protein | - |
| GFB63_RS01435 (GFB63_01490) | - | 296052..297119 (-) | 1068 | WP_024703947.1 | glycosyltransferase | - |
| GFB63_RS01440 (GFB63_01495) | - | 297139..298344 (-) | 1206 | WP_084828993.1 | ABC transporter ATP-binding protein | - |
| GFB63_RS01445 (GFB63_01500) | - | 298344..299153 (-) | 810 | WP_084828994.1 | ABC transporter permease | - |
| GFB63_RS01450 (GFB63_01505) | - | 299137..300093 (-) | 957 | WP_180482505.1 | glycosyltransferase family 2 protein | - |
| GFB63_RS01455 (GFB63_01510) | cps2T | 300090..301238 (-) | 1149 | WP_024703950.1 | beta 1-4 rhamnosyltransferase Cps2T | - |
| GFB63_RS01460 (GFB63_01515) | - | 301345..302886 (-) | 1542 | WP_024703951.1 | DUF2142 domain-containing protein | - |
| GFB63_RS01465 (GFB63_01520) | - | 302893..303903 (-) | 1011 | WP_024703952.1 | glycosyltransferase | - |
| GFB63_RS01470 (GFB63_01525) | - | 303903..305177 (-) | 1275 | WP_024703953.1 | lipopolysaccharide biosynthesis protein | - |
| GFB63_RS01475 (GFB63_01530) | - | 305170..305502 (-) | 333 | WP_084829000.1 | DUF2304 domain-containing protein | - |
| GFB63_RS01480 (GFB63_01535) | - | 305508..306203 (-) | 696 | WP_024703954.1 | glycosyltransferase family 2 protein | - |
| GFB63_RS01485 (GFB63_01540) | rfbD | 306280..307131 (-) | 852 | WP_100284792.1 | dTDP-4-dehydrorhamnose reductase | - |
| GFB63_RS01490 (GFB63_01545) | - | 307599..308510 (-) | 912 | WP_228024403.1 | DUF2142 domain-containing protein | - |
| GFB63_RS01495 (GFB63_01550) | - | 308515..309441 (-) | 927 | WP_193838346.1 | glycosyltransferase family 2 protein | - |
| GFB63_RS01500 (GFB63_01555) | - | 309452..309787 (-) | 336 | WP_002891474.1 | metal-sulfur cluster assembly factor | - |
| GFB63_RS01505 (GFB63_01560) | rpoD | 309841..310950 (-) | 1110 | WP_179972112.1 | RNA polymerase sigma factor RpoD | - |
| GFB63_RS01510 (GFB63_01565) | dnaG | 310954..312765 (-) | 1812 | WP_193838347.1 | DNA primase | - |
| GFB63_RS01515 (GFB63_01570) | mscL | 312928..313308 (+) | 381 | WP_193838428.1 | large conductance mechanosensitive channel protein MscL | - |
| GFB63_RS01520 (GFB63_01575) | rpsU | 313467..313643 (-) | 177 | WP_082309068.1 | 30S ribosomal protein S21 | - |
| GFB63_RS01525 (GFB63_01580) | - | 313837..314631 (-) | 795 | WP_082309069.1 | ABC transporter substrate-binding protein | - |
| GFB63_RS01530 (GFB63_01585) | - | 314693..315802 (-) | 1110 | WP_084829004.1 | aminotransferase | - |
| GFB63_RS01535 (GFB63_01590) | - | 316149..316949 (-) | 801 | WP_100273656.1 | transporter substrate-binding domain-containing protein | - |
| GFB63_RS01540 (GFB63_01595) | - | 316946..317773 (-) | 828 | WP_100262342.1 | transporter substrate-binding domain-containing protein | - |
| GFB63_RS01545 (GFB63_01600) | - | 317988..318452 (-) | 465 | WP_011681454.1 | 8-oxo-dGTP diphosphatase | - |
| GFB63_RS01550 (GFB63_01605) | uvrB | 318497..320488 (-) | 1992 | WP_041827755.1 | excinuclease ABC subunit UvrB | - |
| GFB63_RS01555 (GFB63_01610) | - | 320635..321102 (-) | 468 | WP_065972467.1 | hypothetical protein | - |
| GFB63_RS11020 (GFB63_01615) | - | 321175..322113 (-) | 939 | Protein_321 | CPBP family intramembrane glutamic endopeptidase | - |
| GFB63_RS01565 (GFB63_01620) | - | 322347..324521 (+) | 2175 | WP_193838348.1 | ABC transporter substrate-binding protein/permease | - |
| GFB63_RS01570 (GFB63_01625) | - | 324521..325261 (+) | 741 | WP_011681459.1 | amino acid ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 623 a.a. Molecular weight: 67905.81 Da Isoelectric Point: 6.9480
>NTDB_id=395443 GFB63_RS01255 WP_084826071.1 260687..262558(-) (stkP/pknB) [Streptococcus thermophilus strain TK-P3A]
MIQVGKLFAGRYRILKSIGRGGMADVYLANDLILDNESVAIKVLRTNYQTDQVAVARFQREARAMTELSHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKFIQDHAPLSNQDVVRIMGEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGRAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPFDGDSAVTIALQHFQKPLPSILAENRNVP
QALENVVIRATAKKLENRYNSTLEMSRDLATSLHPSHSRDSKVVFDDMTDTKTLPKVDSVPSVGPEKKISPKPSEPTPAP
SKQPREKASLSKKKKNLFLTLLKVLLGFVFIGIIIFAYLVFTNPDNVQVPNVVGQELSTAQTKLESAGFKVGDVKEVEND
SVNKGKVIKTDPTAGTMRKEGASIDVYVSSGSKGFTLKNYKGKNYKDAIEDLTSNYGVSEDQIDIQHVEDDNAKEGEILS
QSPEKNKSFNPKDSKAKIKFRVATPKTITMPDVTGLTVSTAVQTLNSKDISSSSIEYHDYNTGVKLDKSKVPSNTEVLYQ
DPQVGTAVDGTVILYVSVVTKSSSIQQSSSASTTQSPSSTSSSSESSTASSTETATEATHTEQ
MIQVGKLFAGRYRILKSIGRGGMADVYLANDLILDNESVAIKVLRTNYQTDQVAVARFQREARAMTELSHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKFIQDHAPLSNQDVVRIMGEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGRAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPFDGDSAVTIALQHFQKPLPSILAENRNVP
QALENVVIRATAKKLENRYNSTLEMSRDLATSLHPSHSRDSKVVFDDMTDTKTLPKVDSVPSVGPEKKISPKPSEPTPAP
SKQPREKASLSKKKKNLFLTLLKVLLGFVFIGIIIFAYLVFTNPDNVQVPNVVGQELSTAQTKLESAGFKVGDVKEVEND
SVNKGKVIKTDPTAGTMRKEGASIDVYVSSGSKGFTLKNYKGKNYKDAIEDLTSNYGVSEDQIDIQHVEDDNAKEGEILS
QSPEKNKSFNPKDSKAKIKFRVATPKTITMPDVTGLTVSTAVQTLNSKDISSSSIEYHDYNTGVKLDKSKVPSNTEVLYQ
DPQVGTAVDGTVILYVSVVTKSSSIQQSSSASTTQSPSSTSSSSESSTASSTETATEATHTEQ
Nucleotide
Download Length: 1872 bp
>NTDB_id=395443 GFB63_RS01255 WP_084826071.1 260687..262558(-) (stkP/pknB) [Streptococcus thermophilus strain TK-P3A]
ATGATCCAAGTTGGCAAATTGTTTGCTGGACGTTATCGAATCCTTAAATCTATCGGACGTGGTGGTATGGCGGATGTTTA
TCTGGCTAACGACCTGATTCTGGATAATGAAAGTGTAGCTATTAAGGTGCTACGTACCAATTATCAAACTGATCAGGTTG
CTGTGGCGCGTTTCCAGCGTGAAGCACGTGCCATGACTGAGCTTAGCCATCCGAATATCGTTGCGATTAGAGATATTGGT
GAAGAAGACGGTCAGCAGTTCTTGGTGATGGAGTATGTGGATGGTTCGGACTTGAAGAAATTCATTCAAGACCATGCACC
ATTGTCTAACCAAGATGTTGTGCGTATTATGGGGGAAGTCCTTTCCGCCATGACTCTTGCCCACCAAAAGGGTATTATTC
ACCGTGACCTTAAGCCACAGAACGTTCTATTAACTAAGGATGGTAGAGCTAAGGTTACAGACTTTGGTATCGCAGTAGCA
TTTGCTGAAACCAGCCTGACACAAACTAACTCAATGTTGGGGTCAGTCCATTATTTGTCACCAGAACAGGCACGTGGTTC
TAAAGCCACTATCCAAAGTGATATCTATGCTATGGGGATTATGCTCTTTGAAATGTTGACAGGGCATATCCCTTTTGATG
GCGATAGTGCAGTAACCATTGCACTTCAACATTTCCAAAAGCCCCTGCCATCGATTTTGGCTGAGAACCGTAACGTTCCT
CAAGCTTTAGAAAATGTTGTTATTAGAGCAACTGCTAAAAAGCTTGAAAATCGTTACAACAGCACTTTGGAAATGAGTCG
CGACCTAGCAACTAGTTTGCATCCTAGTCATAGTCGTGATTCTAAGGTAGTTTTTGATGACATGACGGATACTAAGACCC
TGCCAAAGGTCGATTCAGTTCCATCAGTAGGTCCTGAGAAAAAGATTTCTCCTAAACCATCAGAGCCTACACCGGCTCCA
AGCAAACAACCGAGGGAAAAAGCTTCTCTATCTAAAAAAAAGAAAAATCTCTTTTTAACTCTACTCAAGGTTTTACTAGG
CTTCGTCTTTATAGGAATTATCATTTTTGCCTATCTTGTTTTTACCAATCCTGACAATGTCCAAGTACCAAATGTTGTAG
GTCAAGAGTTGTCAACAGCTCAGACGAAACTTGAAAGTGCAGGCTTTAAGGTTGGCGATGTTAAAGAAGTCGAAAATGAT
TCAGTCAATAAGGGCAAAGTTATCAAGACCGACCCTACAGCTGGGACAATGCGTAAAGAGGGAGCAAGCATTGATGTCTA
TGTTTCTTCTGGTAGCAAAGGTTTCACTCTGAAAAATTACAAGGGGAAAAATTATAAGGATGCCATTGAGGATTTAACCT
CGAATTATGGGGTTTCCGAGGATCAGATCGATATTCAACATGTCGAAGACGATAATGCTAAAGAAGGCGAAATTCTATCT
CAAAGTCCGGAGAAAAACAAGTCCTTCAATCCTAAAGATAGTAAGGCAAAAATCAAGTTTCGTGTGGCAACTCCTAAGAC
TATAACTATGCCTGATGTGACTGGTTTAACTGTCTCGACAGCAGTCCAAACCTTGAATAGTAAAGACATTTCAAGTAGCA
GTATTGAGTATCATGACTATAATACTGGTGTTAAGTTGGATAAGAGTAAGGTACCTAGTAATACAGAGGTCCTTTATCAA
GATCCTCAAGTTGGTACTGCTGTTGATGGCACAGTGATTCTCTATGTTTCAGTCGTAACTAAGAGTTCAAGTATTCAACA
GTCAAGCTCAGCAAGTACGACACAATCGCCGTCATCTACAAGTTCTAGTTCTGAAAGTAGTACAGCTTCTAGTACCGAAA
CAGCTACAGAAGCTACTCACACAGAGCAATAA
ATGATCCAAGTTGGCAAATTGTTTGCTGGACGTTATCGAATCCTTAAATCTATCGGACGTGGTGGTATGGCGGATGTTTA
TCTGGCTAACGACCTGATTCTGGATAATGAAAGTGTAGCTATTAAGGTGCTACGTACCAATTATCAAACTGATCAGGTTG
CTGTGGCGCGTTTCCAGCGTGAAGCACGTGCCATGACTGAGCTTAGCCATCCGAATATCGTTGCGATTAGAGATATTGGT
GAAGAAGACGGTCAGCAGTTCTTGGTGATGGAGTATGTGGATGGTTCGGACTTGAAGAAATTCATTCAAGACCATGCACC
ATTGTCTAACCAAGATGTTGTGCGTATTATGGGGGAAGTCCTTTCCGCCATGACTCTTGCCCACCAAAAGGGTATTATTC
ACCGTGACCTTAAGCCACAGAACGTTCTATTAACTAAGGATGGTAGAGCTAAGGTTACAGACTTTGGTATCGCAGTAGCA
TTTGCTGAAACCAGCCTGACACAAACTAACTCAATGTTGGGGTCAGTCCATTATTTGTCACCAGAACAGGCACGTGGTTC
TAAAGCCACTATCCAAAGTGATATCTATGCTATGGGGATTATGCTCTTTGAAATGTTGACAGGGCATATCCCTTTTGATG
GCGATAGTGCAGTAACCATTGCACTTCAACATTTCCAAAAGCCCCTGCCATCGATTTTGGCTGAGAACCGTAACGTTCCT
CAAGCTTTAGAAAATGTTGTTATTAGAGCAACTGCTAAAAAGCTTGAAAATCGTTACAACAGCACTTTGGAAATGAGTCG
CGACCTAGCAACTAGTTTGCATCCTAGTCATAGTCGTGATTCTAAGGTAGTTTTTGATGACATGACGGATACTAAGACCC
TGCCAAAGGTCGATTCAGTTCCATCAGTAGGTCCTGAGAAAAAGATTTCTCCTAAACCATCAGAGCCTACACCGGCTCCA
AGCAAACAACCGAGGGAAAAAGCTTCTCTATCTAAAAAAAAGAAAAATCTCTTTTTAACTCTACTCAAGGTTTTACTAGG
CTTCGTCTTTATAGGAATTATCATTTTTGCCTATCTTGTTTTTACCAATCCTGACAATGTCCAAGTACCAAATGTTGTAG
GTCAAGAGTTGTCAACAGCTCAGACGAAACTTGAAAGTGCAGGCTTTAAGGTTGGCGATGTTAAAGAAGTCGAAAATGAT
TCAGTCAATAAGGGCAAAGTTATCAAGACCGACCCTACAGCTGGGACAATGCGTAAAGAGGGAGCAAGCATTGATGTCTA
TGTTTCTTCTGGTAGCAAAGGTTTCACTCTGAAAAATTACAAGGGGAAAAATTATAAGGATGCCATTGAGGATTTAACCT
CGAATTATGGGGTTTCCGAGGATCAGATCGATATTCAACATGTCGAAGACGATAATGCTAAAGAAGGCGAAATTCTATCT
CAAAGTCCGGAGAAAAACAAGTCCTTCAATCCTAAAGATAGTAAGGCAAAAATCAAGTTTCGTGTGGCAACTCCTAAGAC
TATAACTATGCCTGATGTGACTGGTTTAACTGTCTCGACAGCAGTCCAAACCTTGAATAGTAAAGACATTTCAAGTAGCA
GTATTGAGTATCATGACTATAATACTGGTGTTAAGTTGGATAAGAGTAAGGTACCTAGTAATACAGAGGTCCTTTATCAA
GATCCTCAAGTTGGTACTGCTGTTGATGGCACAGTGATTCTCTATGTTTCAGTCGTAACTAAGAGTTCAAGTATTCAACA
GTCAAGCTCAGCAAGTACGACACAATCGCCGTCATCTACAAGTTCTAGTTCTGAAAGTAGTACAGCTTCTAGTACCGAAA
CAGCTACAGAAGCTACTCACACAGAGCAATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| stkP/pknB | Streptococcus salivarius strain HSISS4 |
90.706 |
93.258 |
0.846 |
| pknB | Streptococcus mutans UA159 |
64.89 |
87.319 |
0.567 |
| stkP | Streptococcus pneumoniae TIGR4 |
58.3 |
79.294 |
0.462 |
| stkP | Streptococcus pneumoniae D39 |
58.097 |
79.294 |
0.461 |
| stkP | Streptococcus pneumoniae R6 |
58.097 |
79.294 |
0.461 |
| stkP | Streptococcus pneumoniae Rx1 |
57.895 |
79.294 |
0.459 |