Detailed information NTG0037586

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: HMPREF0837_RS01275
• Genome accession: NC_014251
• Coordinates: 240548..241300 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae TCH8431/19A
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 235548..246300

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF0837_RS01245 (HMPREF0837_10245)	-	235926..238478 (+)	2553	WP_000834680.1	YfhO family protein	-
HMPREF0837_RS13250	-	238509..239583 (-)	1075	Protein_225	YhgE/Pip family protein	-
HMPREF0837_RS01260 (HMPREF0837_10248)	-	239763..240305 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
HMPREF0837_RS01275 (HMPREF0837_10249)	comE	240548..241300 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
HMPREF0837_RS01280 (HMPREF0837_10250)	comD/comD1	241297..242622 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
HMPREF0837_RS01285 (HMPREF0837_10251)	comC/comC1	242643..242768 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
HMPREF0837_RS01295 (HMPREF0837_10252)	rlmH	243050..243529 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
HMPREF0837_RS01300 (HMPREF0837_10253)	htrA	243712..244893 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
HMPREF0837_RS01305 (HMPREF0837_10254)	spo0J	244951..245709 (+)	759	WP_000410376.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=37586 HMPREF0837_RS01275 WP_000866065.1 240548..241300(-) (comE) [Streptococcus pneumoniae TCH8431/19A]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=37586 HMPREF0837_RS01275 WP_000866065.1 240548..241300(-) (comE) [Streptococcus pneumoniae TCH8431/19A]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408