Detailed information NTG0355631

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: E5Q10_RS10890
• Genome accession: NZ_CP038808
• Coordinates: 2033244..2033996 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain R6CIB17
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2028244..2038996

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E5Q10_RS11780	-	2030677..2032280 (-)	1604	Protein_2012	YhgE/Pip family protein	-
E5Q10_RS10875 (E5Q10_10870)	-	2032459..2033001 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
E5Q10_RS10890 (E5Q10_10885)	comE	2033244..2033996 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
E5Q10_RS10895 (E5Q10_10890)	comD/comD1	2033993..2035318 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
E5Q10_RS10900 (E5Q10_10895)	comC/comC1	2035339..2035464 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
E5Q10_RS10910 (E5Q10_10905)	rlmH	2035746..2036225 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
E5Q10_RS10915 (E5Q10_10910)	htrA	2036408..2037589 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
E5Q10_RS10920 (E5Q10_10915)	spo0J	2037647..2038405 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=355631 E5Q10_RS10890 WP_000866065.1 2033244..2033996(-) (comE) [Streptococcus pneumoniae strain R6CIB17]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=355631 E5Q10_RS10890 WP_000866065.1 2033244..2033996(-) (comE) [Streptococcus pneumoniae strain R6CIB17]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACATATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408