Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   ES300_RS08910 Genome accession   NZ_CP038251
Coordinates   1751066..1752322 (-) Length   418 a.a.
NCBI ID   WP_000642709.1    Uniprot ID   A0A0E8AGF5
Organism   Streptococcus pneumoniae strain TVO_1901944     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1742888..1766157 1751066..1752322 within 0


Gene organization within MGE regions


Location: 1742888..1766157
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ES300_RS08860 (ES300_09325) - 1742888..1743148 (-) 261 WP_001209196.1 hypothetical protein -
  ES300_RS08865 (ES300_09330) - 1743207..1743758 (-) 552 WP_001111264.1 hypothetical protein -
  ES300_RS08870 (ES300_09340) - 1743748..1744738 (-) 991 Protein_1763 hypothetical protein -
  ES300_RS08875 (ES300_09345) - 1745146..1745571 (-) 426 WP_000204060.1 hypothetical protein -
  ES300_RS08880 (ES300_09350) - 1745705..1746058 (-) 354 WP_001829107.1 ImmA/IrrE family metallo-endopeptidase -
  ES300_RS08885 (ES300_09355) - 1746104..1746310 (-) 207 WP_000366087.1 hypothetical protein -
  ES300_RS08890 (ES300_09360) - 1746297..1746458 (-) 162 WP_000289348.1 helix-turn-helix domain-containing protein -
  ES300_RS08895 (ES300_09365) lytA 1746836..1747792 (-) 957 WP_000405240.1 N-acetylmuramoyl-L-alanine amidase LytA -
  ES300_RS08900 (ES300_09370) - 1748168..1749538 (-) 1371 WP_001036285.1 MATE family efflux transporter -
  ES300_RS08905 (ES300_09380) recA 1749845..1751011 (-) 1167 WP_001085462.1 recombinase RecA Machinery gene
  ES300_RS08910 (ES300_09385) cinA 1751066..1752322 (-) 1257 WP_000642709.1 competence/damage-inducible protein A Machinery gene
  ES300_RS08915 (ES300_09390) brpA 1752407..1753423 (-) 1017 WP_000239278.1 biofilm formation/cell division transcriptional regulator BrpA -
  ES300_RS08920 (ES300_09395) - 1753431..1753949 (-) 519 WP_000455535.1 GNAT family N-acetyltransferase -
  ES300_RS08925 (ES300_09400) tsaE 1753939..1754382 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  ES300_RS08930 (ES300_09405) comM 1754468..1755088 (-) 621 WP_000839908.1 hypothetical protein Regulator
  ES300_RS08935 (ES300_09415) - 1755471..1756334 (-) 864 WP_001093618.1 helix-turn-helix domain-containing protein -
  ES300_RS10690 (ES300_09420) - 1756526..1756696 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  ES300_RS08940 (ES300_09425) pneA1 1756799..1757023 (+) 225 WP_000181086.1 two-peptide bacteriocin subunit PneA1 -
  ES300_RS08945 (ES300_09430) pneA2 1757030..1757218 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  ES300_RS08950 (ES300_09435) - 1757335..1760325 (+) 2991 WP_000875571.1 type 2 lanthipeptide synthetase LanM family protein -
  ES300_RS08955 (ES300_09440) - 1760675..1761379 (+) 705 WP_001033170.1 flavodoxin family protein -
  ES300_RS08960 (ES300_09445) - 1761360..1762289 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  ES300_RS08965 (ES300_09450) - 1762286..1764394 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  ES300_RS08970 (ES300_09455) - 1764418..1766157 (+) 1740 WP_054381205.1 S8 family serine peptidase -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45075.48 Da        Isoelectric Point: 4.6064

>NTDB_id=352565 ES300_RS08910 WP_000642709.1 1751066..1752322(-) (cinA) [Streptococcus pneumoniae strain TVO_1901944]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFKGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQEQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=352565 ES300_RS08910 WP_000642709.1 1751066..1752322(-) (cinA) [Streptococcus pneumoniae strain TVO_1901944]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTAAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACCGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGAGCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CATATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Competence-damaged protein (CinA)

(262-414)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E8AGF5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae TIGR4

99.522

100

0.995
  cinA Streptococcus pneumoniae Rx1

99.282

100

0.993
  cinA Streptococcus pneumoniae R6

99.282

100

0.993
  cinA Streptococcus pneumoniae D39

99.043

100

0.99
  cinA Streptococcus mitis SK321

94.019

100

0.94
  cinA Streptococcus mitis NCTC 12261

93.78

100

0.938
  cinA Streptococcus mutans UA159

71.053

100

0.711
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment