Detailed information NTG0342954

Bioinformatically predicted

Overview

• Name: comGC
• Type: Machinery gene
• Locus tag: FSA40_RS09295
• Genome accession: NZ_CP044493
• Coordinates: 1830499..1830813 (-)
• Length: 104 a.a.
• NCBI ID: WP_002263437.1
• Uniprot ID: Q8DS51
• Organism: Streptococcus mutans strain MD
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1825499..1835813

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FSA40_RS09255 (FSA40_1859)	-	1825582..1826022 (-)	441	WP_002263445.1	hypothetical protein	-
FSA40_RS09260 (FSA40_1860)	-	1825991..1826236 (-)	246	WP_002263444.1	helix-turn-helix transcriptional regulator	-
FSA40_RS09265 (FSA40_1861)	-	1826789..1827988 (-)	1200	WP_002263443.1	acetate kinase	-
FSA40_RS09270 (FSA40_1862)	comGH	1828047..1829000 (-)	954	WP_002264244.1	class I SAM-dependent methyltransferase	Machinery gene
FSA40_RS09275 (FSA40_1863)	comGG	1829055..1829444 (-)	390	WP_002263441.1	competence type IV pilus minor pilin ComGG	Machinery gene
FSA40_RS09280 (FSA40_1864)	comGF	1829422..1829856 (-)	435	WP_151416443.1	competence type IV pilus minor pilin ComGF	Machinery gene
FSA40_RS09285 (FSA40_1865)	comGE	1829843..1830136 (-)	294	WP_002263439.1	competence type IV pilus minor pilin ComGE	Machinery gene
FSA40_RS09290 (FSA40_1866)	comGD	1830108..1830512 (-)	405	WP_002264246.1	competence type IV pilus minor pilin ComGD	Machinery gene
FSA40_RS09295 (FSA40_1867)	comGC	1830499..1830813 (-)	315	WP_002263437.1	competence type IV pilus major pilin ComGC	Machinery gene
FSA40_RS09300 (FSA40_1868)	comGB	1830813..1831844 (-)	1032	WP_255262721.1	competence type IV pilus assembly protein ComGB	Machinery gene
FSA40_RS09305 (FSA40_1869)	comGA	1831780..1832721 (-)	942	WP_151416444.1	competence type IV pilus ATPase ComGA	Machinery gene
FSA40_RS09310 (FSA40_1870)	-	1832851..1833234 (-)	384	WP_002263434.1	DUF1033 family protein	-

Sequence

Protein

• Length: 104 a.a.
• Molecular weight: 11591.60 Da
• Isoelectric Point: 10.2206

>NTDB_id=342954 FSA40_RS09295 WP_002263437.1 1830499..1830813(-) (comGC) [Streptococcus mutans strain MD]
MKKIKRVSVRAFTLIEMLVVLLIISILLLLFVPNLTKQKDKVKDTGGSAVVKVVESQAELYELNKTDSATLSKLVASGDI
TQEQANSYKDYYAKHPSKTRHVAN

Nucleotide

• Length: 315 bp

>NTDB_id=342954 FSA40_RS09295 WP_002263437.1 1830499..1830813(-) (comGC) [Streptococcus mutans strain MD]
ATGAAAAAGATCAAGAGAGTCAGTGTACGGGCTTTTACGCTTATAGAAATGTTAGTAGTTCTTCTCATTATTAGTATTCT
TTTACTATTATTTGTTCCTAATTTAACTAAGCAAAAAGATAAGGTAAAAGATACTGGCGGTTCTGCCGTGGTTAAAGTTG
TAGAAAGTCAGGCTGAGCTTTATGAGCTTAATAAAACCGATTCTGCTACTCTTTCTAAATTAGTAGCTAGTGGTGATATT
ACACAAGAACAGGCAAATTCATACAAGGATTACTATGCAAAACACCCAAGTAAAACACGGCATGTCGCGAATTAA

Domains

Predicted by InterProScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (9-30)

3D structure

• AlphaFold DB: Q8DS51

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGC	Streptococcus mutans UA140	100	100	1
comGC	Streptococcus mutans UA159	100	100	1
comGC	Streptococcus gordonii str. Challis substr. CH1	71.429	100	0.721
comGC/cglC	Streptococcus mitis SK321	66.667	95.192	0.635
comGC/cglC	Streptococcus mitis NCTC 12261	69.565	88.462	0.615
comGC/cglC	Streptococcus pneumoniae R6	63.636	95.192	0.606
comGC/cglC	Streptococcus pneumoniae Rx1	63.636	95.192	0.606
comGC/cglC	Streptococcus pneumoniae D39	63.636	95.192	0.606
comGC/cglC	Streptococcus pneumoniae TIGR4	63.636	95.192	0.606
comGC	Lactococcus lactis subsp. cremoris KW2	55.446	97.115	0.538
comGC	Streptococcus suis isolate S10	60.227	84.615	0.51