Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGE   Type   Machinery gene
Locus tag   FSA40_RS09285 Genome accession   NZ_CP044493
Coordinates   1829843..1830136 (-) Length   97 a.a.
NCBI ID   WP_002263439.1    Uniprot ID   Q8DS53
Organism   Streptococcus mutans strain MD     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1824843..1835136
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FSA40_RS09250 (FSA40_1858) - 1824867..1825529 (-) 663 WP_002266816.1 type II CAAX endopeptidase family protein -
  FSA40_RS09255 (FSA40_1859) - 1825582..1826022 (-) 441 WP_002263445.1 hypothetical protein -
  FSA40_RS09260 (FSA40_1860) - 1825991..1826236 (-) 246 WP_002263444.1 helix-turn-helix transcriptional regulator -
  FSA40_RS09265 (FSA40_1861) - 1826789..1827988 (-) 1200 WP_002263443.1 acetate kinase -
  FSA40_RS09270 (FSA40_1862) comGH 1828047..1829000 (-) 954 WP_002264244.1 class I SAM-dependent methyltransferase Machinery gene
  FSA40_RS09275 (FSA40_1863) comGG 1829055..1829444 (-) 390 WP_002263441.1 competence type IV pilus minor pilin ComGG Machinery gene
  FSA40_RS09280 (FSA40_1864) comGF 1829422..1829856 (-) 435 WP_151416443.1 competence type IV pilus minor pilin ComGF Machinery gene
  FSA40_RS09285 (FSA40_1865) comGE 1829843..1830136 (-) 294 WP_002263439.1 competence type IV pilus minor pilin ComGE Machinery gene
  FSA40_RS09290 (FSA40_1866) comGD 1830108..1830512 (-) 405 WP_002264246.1 competence type IV pilus minor pilin ComGD Machinery gene
  FSA40_RS09295 (FSA40_1867) comGC 1830499..1830813 (-) 315 WP_002263437.1 competence type IV pilus major pilin ComGC Machinery gene
  FSA40_RS09300 (FSA40_1868) comGB 1830813..1831844 (-) 1032 WP_255262721.1 competence type IV pilus assembly protein ComGB Machinery gene
  FSA40_RS09305 (FSA40_1869) comGA 1831780..1832721 (-) 942 WP_151416444.1 competence type IV pilus ATPase ComGA Machinery gene
  FSA40_RS09310 (FSA40_1870) - 1832851..1833234 (-) 384 WP_002263434.1 DUF1033 family protein -

Sequence

Protein


Download         Length: 97 a.a.        Molecular weight: 11001.91 Da        Isoelectric Point: 9.4908

>NTDB_id=342952 FSA40_RS09285 WP_002263439.1 1829843..1830136(-) (comGE) [Streptococcus mutans strain MD]
MVSIKKQKVKAYILLESLVALGLFVTITTLILTQLSHYQERTAKNLQKQEILNLAIMALQTQQDHLSFNGVSVTVVKNQG
ETIVYHDHEEVINLVKK

Nucleotide


Download         Length: 294 bp        

>NTDB_id=342952 FSA40_RS09285 WP_002263439.1 1829843..1830136(-) (comGE) [Streptococcus mutans strain MD]
GTGGTCAGTATAAAAAAACAGAAAGTTAAAGCTTATATTCTTCTAGAAAGTTTAGTTGCTTTGGGACTTTTCGTAACCAT
CACAACTTTAATTCTTACTCAGTTGAGTCATTATCAGGAAAGAACAGCTAAAAATTTACAAAAACAAGAAATATTGAATT
TAGCAATAATGGCTCTTCAAACTCAGCAAGATCATTTAAGCTTCAACGGCGTCAGTGTTACGGTTGTTAAAAATCAAGGG
GAAACTATAGTTTATCATGATCATGAGGAGGTTATCAATCTTGTTAAAAAGTGA

Domains

Predicted by InterProScan.

Type II secretory pathway pseudopilin (ComGE)

(13-94)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DS53

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGE Streptococcus mutans UA140

100

100

1
  comGE Streptococcus mutans UA159

100

100

1
  comGE/cglE Streptococcus pneumoniae Rx1

44.444

92.784

0.412
  comGE/cglE Streptococcus pneumoniae D39

44.444

92.784

0.412
  comGE/cglE Streptococcus pneumoniae R6

44.444

92.784

0.412
  comGE/cglE Streptococcus pneumoniae TIGR4

44.444

92.784

0.412
  comGE/cglE Streptococcus mitis NCTC 12261

44.444

92.784

0.412
  comGE/cglE Streptococcus mitis SK321

44.444

92.784

0.412