Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   ETT56_RS09235 Genome accession   NZ_CP035443
Coordinates   1806475..1807746 (-) Length   423 a.a.
NCBI ID   WP_023610745.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm58     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1796753..1823124 1806475..1807746 within 0


Gene organization within MGE regions


Location: 1796753..1823124
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT56_RS09185 (ETT56_09175) nrdG 1796753..1797367 (-) 615 WP_021775544.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  ETT56_RS09190 (ETT56_09180) - 1797382..1797876 (-) 495 WP_014407930.1 GNAT family N-acetyltransferase -
  ETT56_RS09195 (ETT56_09185) - 1797885..1798820 (-) 936 WP_023610759.1 Gfo/Idh/MocA family protein -
  ETT56_RS09765 - 1798849..1798995 (-) 147 WP_023610752.1 hypothetical protein -
  ETT56_RS09200 (ETT56_09190) nrdD 1799177..1801375 (-) 2199 WP_002992831.1 anaerobic ribonucleoside-triphosphate reductase -
  ETT56_RS09205 (ETT56_09195) - 1801472..1803031 (-) 1560 WP_011055088.1 membrane protein -
  ETT56_RS09210 (ETT56_09200) - 1803445..1803750 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  ETT56_RS09215 (ETT56_09205) ruvX 1803762..1804181 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  ETT56_RS09220 (ETT56_09210) - 1804178..1804447 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  ETT56_RS09225 (ETT56_09215) spx 1804561..1804959 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  ETT56_RS09230 (ETT56_09220) recA 1805250..1806386 (-) 1137 WP_023610714.1 recombinase RecA Machinery gene
  ETT56_RS09235 (ETT56_09225) cinA 1806475..1807746 (-) 1272 WP_023610745.1 competence/damage-inducible protein A Machinery gene
  ETT56_RS09240 (ETT56_09230) - 1807815..1808375 (-) 561 WP_023610776.1 DNA-3-methyladenine glycosylase I -
  ETT56_RS09245 (ETT56_09235) ruvA 1808385..1808981 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA -
  ETT56_RS09250 (ETT56_09240) - 1808983..1810203 (-) 1221 WP_002991361.1 MFS transporter -
  ETT56_RS09255 (ETT56_09245) mutL 1810214..1812196 (-) 1983 WP_023610727.1 DNA mismatch repair endonuclease MutL -
  ETT56_RS09260 (ETT56_09250) - 1812291..1813436 (-) 1146 WP_063632873.1 site-specific integrase -
  ETT56_RS09920 - 1813518..1814186 (-) 669 WP_012560499.1 helix-turn-helix domain-containing protein -
  ETT56_RS09270 (ETT56_09260) - 1814353..1814538 (+) 186 WP_012560498.1 DNA-binding transcriptional regulator -
  ETT56_RS09275 (ETT56_09265) - 1814554..1814802 (+) 249 WP_063632871.1 hypothetical protein -
  ETT56_RS09280 (ETT56_09270) - 1815330..1815539 (+) 210 WP_009880499.1 hypothetical protein -
  ETT56_RS09925 (ETT56_09275) - 1815536..1815727 (+) 192 WP_063632869.1 hypothetical protein -
  ETT56_RS09930 (ETT56_09280) - 1815749..1815943 (+) 195 WP_063632867.1 hypothetical protein -
  ETT56_RS09295 (ETT56_09285) - 1815955..1816284 (+) 330 WP_000174498.1 hypothetical protein -
  ETT56_RS09300 (ETT56_09290) - 1816287..1816559 (+) 273 WP_063631415.1 hypothetical protein -
  ETT56_RS09305 (ETT56_09295) - 1816560..1817417 (+) 858 WP_063632865.1 primase alpha helix C-terminal domain-containing protein -
  ETT56_RS09310 (ETT56_09300) - 1817386..1819074 (+) 1689 WP_063632863.1 phage/plasmid primase, P4 family -
  ETT56_RS09315 (ETT56_09305) - 1819362..1819535 (+) 174 WP_080465172.1 DUF2758 domain-containing protein -
  ETT56_RS09320 (ETT56_09310) - 1819716..1819982 (+) 267 WP_063632861.1 hypothetical protein -
  ETT56_RS09325 (ETT56_09315) - 1819989..1820147 (+) 159 WP_011529115.1 DUF2292 domain-containing protein -
  ETT56_RS09330 (ETT56_09320) - 1820248..1820850 (+) 603 WP_063632859.1 hypothetical protein -
  ETT56_RS09335 (ETT56_09325) - 1820840..1821169 (+) 330 WP_227876756.1 hydrolase -
  ETT56_RS09340 (ETT56_09330) - 1821445..1821711 (+) 267 WP_223824853.1 hypothetical protein -
  ETT56_RS09345 (ETT56_09335) - 1821817..1822230 (+) 414 WP_012560493.1 DUF1492 domain-containing protein -
  ETT56_RS09350 (ETT56_09340) - 1822305..1822505 (+) 201 WP_011529120.1 hypothetical protein -
  ETT56_RS09355 (ETT56_09345) - 1822557..1822766 (+) 210 Protein_1755 sigma factor-like helix-turn-helix DNA-binding protein -
  ETT56_RS09360 (ETT56_09350) - 1822741..1823124 (+) 384 WP_063632854.1 ArpU family phage packaging/lysis transcriptional regulator -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45950.67 Da        Isoelectric Point: 4.8322

>NTDB_id=341883 ETT56_RS09235 WP_023610745.1 1806475..1807746(-) (cinA) [Streptococcus pyogenes strain emm58]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSISLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVAYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=341883 ETT56_RS09235 WP_023610745.1 1806475..1807746(-) (cinA) [Streptococcus pyogenes strain emm58]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTGATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCTCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGGCTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GCTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Competence-damaged protein (CinA)

(263-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.267

100

0.693
  cinA Streptococcus mitis SK321

69.544

98.582

0.686
  cinA Streptococcus mitis NCTC 12261

69.065

98.582

0.681
  cinA Streptococcus pneumoniae TIGR4

68.106

98.582

0.671
  cinA Streptococcus pneumoniae Rx1

68.106

98.582

0.671
  cinA Streptococcus pneumoniae R6

68.106

98.582

0.671
  cinA Streptococcus pneumoniae D39

67.866

98.582

0.669
  cinA Streptococcus suis isolate S10

53.125

98.345

0.522
  cinA Bacillus subtilis subsp. subtilis str. 168

46.651

98.818

0.461

Multiple sequence alignment