Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   ETT57_RS00665 Genome accession   NZ_CP035442
Coordinates   101966..102904 (+) Length   312 a.a.
NCBI ID   WP_009880361.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm25     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 96966..107904
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT57_RS00655 (ETT57_00655) rpoC 97733..101356 (+) 3624 WP_136048776.1 DNA-directed RNA polymerase subunit beta' -
  ETT57_RS00660 (ETT57_00660) - 101508..101873 (+) 366 WP_002986560.1 DUF1033 family protein -
  ETT57_RS00665 (ETT57_00665) comYA 101966..102904 (+) 939 WP_009880361.1 competence type IV pilus ATPase ComGA Machinery gene
  ETT57_RS00670 (ETT57_00670) comYB 102840..103874 (+) 1035 WP_227877779.1 competence type IV pilus assembly protein ComGB Machinery gene
  ETT57_RS00675 (ETT57_00675) comGC 103876..104202 (+) 327 WP_053308148.1 competence type IV pilus major pilin ComGC Machinery gene
  ETT57_RS00680 (ETT57_00680) comGD 104177..104605 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  ETT57_RS00685 (ETT57_00685) comGE 104562..104846 (+) 285 WP_011284422.1 competence type IV pilus minor pilin ComGE -
  ETT57_RS00690 (ETT57_00690) comYF 104839..105273 (+) 435 WP_002992738.1 competence type IV pilus minor pilin ComGF Machinery gene
  ETT57_RS00695 (ETT57_00695) comGG 105257..105583 (+) 327 WP_010921801.1 competence type IV pilus minor pilin ComGG -
  ETT57_RS00700 (ETT57_00700) comYH 105681..106634 (+) 954 WP_053308149.1 class I SAM-dependent methyltransferase Machinery gene
  ETT57_RS00705 (ETT57_00705) - 106693..107889 (+) 1197 WP_002987791.1 acetate kinase -

Sequence

Protein


Download         Length: 312 a.a.        Molecular weight: 35017.21 Da        Isoelectric Point: 8.2452

>NTDB_id=341783 ETT57_RS00665 WP_009880361.1 101966..102904(+) (comYA) [Streptococcus pyogenes strain emm25]
MVQALAKAILAKAEQVQAQDIYILPRADQYDLFLRIGDERRLVDVYQSDRMAPLVSHFKFVAGMIVGEKRRCQVGSCDYK
LSKDKQLSLRLSSVGDYRGQESLVIRLLHHQNKSVHYWFDGLTKVANQVGGRGLYLFAGPVGSGKTTLMYQLISNYHQEA
QVISIEDPVEIKNHQILQLQVNDDIGMTYDNLIKLSLRHQPDILVIGEIRDSQTARAVIRASLTGAMVFSTVHAKSISGV
YARLLELGVTKAELSNCLALIAYQRLLNGGALIDSTQNEFEYYSSSNWNQQIDQLLEAGHLNPKQAKLEKII

Nucleotide


Download         Length: 939 bp        

>NTDB_id=341783 ETT57_RS00665 WP_009880361.1 101966..102904(+) (comYA) [Streptococcus pyogenes strain emm25]
ATGGTACAAGCATTAGCAAAAGCTATTCTAGCAAAAGCTGAACAGGTTCAGGCACAAGATATTTATATTTTGCCAAGAGC
AGATCAATATGATCTTTTTTTACGAATAGGAGATGAAAGGAGATTAGTTGATGTTTATCAGAGCGATCGGATGGCTCCTC
TTGTTAGTCACTTTAAATTCGTTGCAGGAATGATAGTTGGTGAAAAGAGACGTTGTCAGGTGGGTTCATGTGATTATAAG
CTCAGTAAAGATAAGCAGTTATCTTTGCGCTTATCTAGCGTGGGTGATTATCGCGGGCAAGAAAGCTTAGTGATTCGTCT
GCTTCATCATCAAAATAAAAGTGTACATTATTGGTTTGATGGATTGACAAAAGTAGCCAATCAGGTTGGCGGTAGAGGGT
TGTATTTATTTGCAGGACCAGTTGGGTCTGGGAAGACAACCTTGATGTACCAGCTGATTTCGAATTATCATCAAGAAGCA
CAGGTTATTAGTATAGAAGATCCTGTAGAAATTAAAAATCACCAGATTTTACAATTACAAGTGAATGATGATATTGGTAT
GACTTATGACAATTTGATCAAACTGTCTTTACGCCATCAACCAGATATTTTAGTTATTGGTGAGATTCGAGATAGTCAAA
CAGCAAGAGCCGTTATTAGGGCTAGTCTAACAGGTGCCATGGTTTTTTCAACGGTTCACGCTAAAAGTATCTCGGGTGTT
TATGCAAGATTGTTAGAACTTGGTGTAACGAAAGCAGAACTGTCTAATTGCTTAGCATTAATTGCTTACCAAAGGTTACT
TAATGGAGGAGCATTGATTGACTCTACTCAAAACGAATTTGAATATTATTCCTCATCGAACTGGAATCAACAAATTGATC
AGCTTCTTGAGGCAGGACATCTCAATCCCAAGCAAGCTAAGCTTGAAAAAATTATCTAG

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus mutans UA159

61.093

99.679

0.609
  comYA Streptococcus mutans UA140

61.093

99.679

0.609
  comYA Streptococcus gordonii str. Challis substr. CH1

60.129

99.679

0.599
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

60

99.359

0.596
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

58.842

99.679

0.587
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

58.199

99.679

0.58
  comGA/cglA/cilD Streptococcus pneumoniae D39

58.199

99.679

0.58
  comGA/cglA/cilD Streptococcus pneumoniae R6

58.199

99.679

0.58
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

58.199

99.679

0.58
  comGA Lactococcus lactis subsp. cremoris KW2

50.161

99.679

0.5
  comGA Latilactobacillus sakei subsp. sakei 23K

39.31

92.949

0.365

Multiple sequence alignment