Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   ETT66_RS08655 Genome accession   NZ_CP035433
Coordinates   1722931..1724202 (-) Length   423 a.a.
NCBI ID   WP_136286627.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm65     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1717931..1729202
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT66_RS08620 (ETT66_08615) - 1718641..1718946 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  ETT66_RS08625 (ETT66_08620) ruvX 1718958..1719377 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  ETT66_RS08630 (ETT66_08625) - 1719374..1719643 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  ETT66_RS08640 (ETT66_08635) - 1719815..1720883 (-) 1069 Protein_1601 ISAs1 family transposase -
  ETT66_RS08645 (ETT66_08640) spx 1721017..1721415 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  ETT66_RS08650 (ETT66_08645) recA 1721706..1722842 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  ETT66_RS08655 (ETT66_08650) cinA 1722931..1724202 (-) 1272 WP_136286627.1 competence/damage-inducible protein A Machinery gene
  ETT66_RS08660 (ETT66_08655) - 1724271..1724832 (-) 562 Protein_1605 DNA-3-methyladenine glycosylase I -
  ETT66_RS08665 (ETT66_08660) ruvA 1724842..1725438 (-) 597 WP_136286625.1 Holliday junction branch migration protein RuvA -
  ETT66_RS08670 (ETT66_08665) - 1725440..1726660 (-) 1221 WP_136286623.1 MFS transporter -
  ETT66_RS08675 (ETT66_08670) mutL 1726671..1728653 (-) 1983 WP_136286621.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 46017.80 Da        Isoelectric Point: 4.9007

>NTDB_id=341346 ETT66_RS08655 WP_136286627.1 1722931..1724202(-) (cinA) [Streptococcus pyogenes strain emm65]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSNLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYVKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=341346 ETT66_RS08655 WP_136286627.1 1722931..1724202(-) (cinA) [Streptococcus pyogenes strain emm65]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTAACTTGGTAATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGTTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Competence-damaged protein (CinA)

(263-416)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.267

100

0.693
  cinA Streptococcus mitis SK321

69.784

98.582

0.688
  cinA Streptococcus mitis NCTC 12261

69.305

98.582

0.683
  cinA Streptococcus pneumoniae TIGR4

68.345

98.582

0.674
  cinA Streptococcus pneumoniae Rx1

68.345

98.582

0.674
  cinA Streptococcus pneumoniae R6

68.345

98.582

0.674
  cinA Streptococcus pneumoniae D39

68.106

98.582

0.671
  cinA Streptococcus suis isolate S10

53.125

98.345

0.522
  cinA Bacillus subtilis subsp. subtilis str. 168

46.172

98.818

0.456

Multiple sequence alignment