Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   ETT68_RS08695 Genome accession   NZ_CP035431
Coordinates   1729833..1731104 (-) Length   423 a.a.
NCBI ID   WP_109991587.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm105     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1724833..1736104
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT68_RS08670 (ETT68_08665) - 1726803..1727108 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  ETT68_RS08675 (ETT68_08670) ruvX 1727120..1727539 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  ETT68_RS08680 (ETT68_08675) - 1727536..1727805 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  ETT68_RS08685 (ETT68_08680) spx 1727919..1728317 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  ETT68_RS08690 (ETT68_08685) recA 1728608..1729744 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  ETT68_RS08695 (ETT68_08690) cinA 1729833..1731104 (-) 1272 WP_109991587.1 competence/damage-inducible protein A Machinery gene
  ETT68_RS08700 (ETT68_08695) - 1731173..1731733 (-) 561 WP_136098684.1 DNA-3-methyladenine glycosylase I -
  ETT68_RS08705 (ETT68_08700) ruvA 1731743..1732339 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA -
  ETT68_RS08710 (ETT68_08705) - 1732341..1733561 (-) 1221 WP_002991361.1 MFS transporter -
  ETT68_RS08715 (ETT68_08710) mutL 1733572..1735554 (-) 1983 WP_002991363.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45954.66 Da        Isoelectric Point: 4.9060

>NTDB_id=341243 ETT68_RS08695 WP_109991587.1 1729833..1731104(-) (cinA) [Streptococcus pyogenes strain emm105]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSISLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLHSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=341243 ETT68_RS08695 WP_109991587.1 1729833..1731104(-) (cinA) [Streptococcus pyogenes strain emm105]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTGATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCTCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGCATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGCGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-416)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.267

100

0.693
  cinA Streptococcus mitis NCTC 12261

69.544

98.582

0.686
  cinA Streptococcus mitis SK321

69.544

98.582

0.686
  cinA Streptococcus pneumoniae TIGR4

68.106

98.582

0.671
  cinA Streptococcus pneumoniae Rx1

68.106

98.582

0.671
  cinA Streptococcus pneumoniae R6

68.106

98.582

0.671
  cinA Streptococcus pneumoniae D39

67.866

98.582

0.669
  cinA Streptococcus suis isolate S10

52.885

98.345

0.52
  cinA Bacillus subtilis subsp. subtilis str. 168

46.651

98.818

0.461

Multiple sequence alignment