Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   ETT70_RS08755 Genome accession   NZ_CP035429
Coordinates   1704320..1705591 (-) Length   423 a.a.
NCBI ID   WP_136112430.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emmNA     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1694599..1722420 1704320..1705591 within 0


Gene organization within MGE regions


Location: 1694599..1722420
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT70_RS08705 (ETT70_08695) nrdG 1694599..1695213 (-) 615 WP_002982219.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  ETT70_RS08710 (ETT70_08700) - 1695228..1695722 (-) 495 WP_136275899.1 GNAT family N-acetyltransferase -
  ETT70_RS08715 (ETT70_08705) - 1695731..1696666 (-) 936 WP_136106359.1 Gfo/Idh/MocA family protein -
  ETT70_RS09270 - 1696695..1696841 (-) 147 WP_011106921.1 hypothetical protein -
  ETT70_RS08720 (ETT70_08710) nrdD 1697023..1699221 (-) 2199 WP_002992831.1 anaerobic ribonucleoside-triphosphate reductase -
  ETT70_RS08725 (ETT70_08715) - 1699318..1700877 (-) 1560 WP_111677537.1 DUF2079 domain-containing protein -
  ETT70_RS08730 (ETT70_08720) - 1701290..1701595 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  ETT70_RS08735 (ETT70_08725) ruvX 1701607..1702026 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  ETT70_RS08740 (ETT70_08730) - 1702023..1702292 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  ETT70_RS08745 (ETT70_08735) spx 1702406..1702804 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  ETT70_RS08750 (ETT70_08740) recA 1703095..1704231 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  ETT70_RS08755 (ETT70_08745) cinA 1704320..1705591 (-) 1272 WP_136112430.1 competence/damage-inducible protein A Machinery gene
  ETT70_RS08760 (ETT70_08750) - 1705660..1706220 (-) 561 WP_002992183.1 DNA-3-methyladenine glycosylase I -
  ETT70_RS08765 (ETT70_08755) ruvA 1706230..1706826 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA -
  ETT70_RS08770 (ETT70_08760) - 1706828..1708048 (-) 1221 WP_002992187.1 MFS transporter -
  ETT70_RS08775 (ETT70_08765) mutL 1708059..1710041 (-) 1983 WP_136076690.1 DNA mismatch repair endonuclease MutL -
  ETT70_RS08780 (ETT70_08770) - 1710136..1711281 (-) 1146 WP_021299091.1 site-specific integrase -
  ETT70_RS08785 (ETT70_08775) - 1711609..1711752 (+) 144 WP_002992192.1 putative holin-like toxin -
  ETT70_RS08790 (ETT70_08780) - 1712601..1713368 (-) 768 WP_003058809.1 helix-turn-helix transcriptional regulator -
  ETT70_RS08795 (ETT70_08785) - 1713522..1713728 (+) 207 WP_002992503.1 helix-turn-helix transcriptional regulator -
  ETT70_RS08800 (ETT70_08790) - 1713762..1713962 (+) 201 WP_002992502.1 helix-turn-helix domain-containing protein -
  ETT70_RS08805 (ETT70_08795) - 1713983..1714390 (+) 408 WP_002992501.1 hypothetical protein -
  ETT70_RS09435 - 1714403..1714525 (+) 123 WP_002992500.1 hypothetical protein -
  ETT70_RS08810 (ETT70_08800) - 1714806..1715327 (+) 522 WP_002992498.1 Rha family transcriptional regulator -
  ETT70_RS08815 (ETT70_08805) - 1715572..1715904 (+) 333 WP_002992497.1 hypothetical protein -
  ETT70_RS08820 (ETT70_08810) - 1715904..1716095 (+) 192 WP_080032246.1 hypothetical protein -
  ETT70_RS08825 (ETT70_08815) - 1716107..1716469 (+) 363 WP_136118488.1 hypothetical protein -
  ETT70_RS08830 (ETT70_08820) - 1716466..1716795 (+) 330 WP_000174505.1 hypothetical protein -
  ETT70_RS08835 (ETT70_08825) - 1716798..1717070 (+) 273 WP_001100459.1 hypothetical protein -
  ETT70_RS08840 (ETT70_08830) - 1717071..1717928 (+) 858 WP_002992489.1 primase alpha helix C-terminal domain-containing protein -
  ETT70_RS08845 (ETT70_08835) - 1717897..1719585 (+) 1689 WP_002992487.1 phage/plasmid primase, P4 family -
  ETT70_RS08850 (ETT70_08840) - 1719872..1720045 (+) 174 WP_003045773.1 hypothetical protein -
  ETT70_RS09275 - 1720051..1720224 (+) 174 WP_164972313.1 hypothetical protein -
  ETT70_RS08855 (ETT70_08845) - 1720226..1720735 (+) 510 WP_032464630.1 hypothetical protein -
  ETT70_RS08860 (ETT70_08850) - 1720809..1721297 (+) 489 WP_002992480.1 hypothetical protein -
  ETT70_RS08870 (ETT70_08860) - 1721700..1722062 (+) 363 WP_003058730.1 DUF1492 domain-containing protein -
  ETT70_RS08875 (ETT70_08865) - 1722037..1722420 (+) 384 WP_023612665.1 ArpU family phage packaging/lysis transcriptional regulator -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45985.69 Da        Isoelectric Point: 4.7648

>NTDB_id=341136 ETT70_RS08755 WP_136112430.1 1704320..1705591(-) (cinA) [Streptococcus pyogenes strain emmNA]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRRDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFEFLVKYDKSITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
CYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=341136 ETT70_RS08755 WP_136112430.1 1704320..1705591(-) (cinA) [Streptococcus pyogenes strain emmNA]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGGAGTGATTTGGTCATTTTATGCGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAGAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGATCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATTACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGTTCTTAGTAAAATATGATAAGTCAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACGGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
TGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-416)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.267

100

0.693
  cinA Streptococcus mitis SK321

69.305

98.582

0.683
  cinA Streptococcus mitis NCTC 12261

68.825

98.582

0.678
  cinA Streptococcus pneumoniae TIGR4

67.866

98.582

0.669
  cinA Streptococcus pneumoniae Rx1

67.866

98.582

0.669
  cinA Streptococcus pneumoniae R6

67.866

98.582

0.669
  cinA Streptococcus pneumoniae D39

67.626

98.582

0.667
  cinA Streptococcus suis isolate S10

52.885

98.345

0.52
  cinA Bacillus subtilis subsp. subtilis str. 168

46.411

98.818

0.459

Multiple sequence alignment