Detailed information NTG0338165

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: MGAS2221_RS08410
• Genome accession: NZ_CP043530
• Coordinates: 1654297..1655037 (-)
• Length: 246 a.a.
• NCBI ID: WP_002986100.1
• Uniprot ID: A0A0H2UT50
• Organism: Streptococcus pyogenes strain MGAS2221
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1649297..1660037

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS2221_RS08385 (MGAS2221_1674)	-	1650252..1650956 (-)	705	WP_010921873.1	N-acetylmannosamine-6-phosphate 2-epimerase	-
MGAS2221_RS08390 (MGAS2221_1675)	rpmH	1651230..1651364 (-)	135	WP_002885866.1	50S ribosomal protein L34	-
MGAS2221_RS08395 (MGAS2221_1676)	jag	1651679..1652593 (-)	915	WP_010921872.1	RNA-binding cell elongation regulator Jag/EloR	-
MGAS2221_RS08400 (MGAS2221_1677)	-	1652605..1653432 (-)	828	WP_010921871.1	YidC/Oxa1 family membrane protein insertase	-
MGAS2221_RS08405 (MGAS2221_1678)	rnpA	1653398..1653757 (-)	360	WP_002992035.1	ribonuclease P protein component	-
MGAS2221_RS08410 (MGAS2221_1679)	comE/blpR	1654297..1655037 (-)	741	WP_002986100.1	LytTR family DNA-binding domain-containing protein	Regulator
MGAS2221_RS08415 (MGAS2221_1680)	-	1655041..1656324 (-)	1284	WP_010921869.1	sensor histidine kinase	-
MGAS2221_RS08420 (MGAS2221_1681)	-	1656321..1657667 (-)	1347	WP_011285380.1	sensor histidine kinase	-
MGAS2221_RS08425 (MGAS2221_1682)	gltX	1658062..1659507 (-)	1446	WP_002986105.1	glutamate--tRNA ligase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28881.47 Da
• Isoelectric Point: 6.4841

>NTDB_id=338165 MGAS2221_RS08410 WP_002986100.1 1654297..1655037(-) (comE/blpR) [Streptococcus pyogenes strain MGAS2221]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=338165 MGAS2221_RS08410 WP_002986100.1 1654297..1655037(-) (comE/blpR) [Streptococcus pyogenes strain MGAS2221]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCCGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCAGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGCAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGATTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCTCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

3D structure

• AlphaFold DB: A0A0H2UT50

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.903	100	0.382
comE/comE2	Streptococcus gordonii strain NCTC7865	37.903	100	0.382
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37