Detailed information NTG0338041

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EQH24_RS11535
• Genome accession: NZ_CP035256
• Coordinates: 2217680..2218432 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_1901930
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2212680..2223432

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH24_RS11505 (EQH24_12075)	-	2213029..2215581 (+)	2553	WP_000834682.1	YfhO family protein	-
EQH24_RS11795 (EQH24_12080)	-	2215611..2216788 (-)	1178	Protein_2263	YhgE/Pip family protein	-
EQH24_RS11520 (EQH24_12085)	-	2216895..2217437 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
EQH24_RS11535 (EQH24_12100)	comE	2217680..2218432 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
EQH24_RS11540 (EQH24_12105)	comD/comD1	2218429..2219754 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
EQH24_RS11545 (EQH24_12110)	comC/comC1	2219775..2219900 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
EQH24_RS11555 (EQH24_12120)	rlmH	2220182..2220661 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EQH24_RS11560 (EQH24_12125)	htrA	2220844..2222025 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
EQH24_RS11565 (EQH24_12130)	spo0J	2222083..2222841 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=338041 EQH24_RS11535 WP_000866065.1 2217680..2218432(-) (comE) [Streptococcus pneumoniae strain TVO_1901930]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=338041 EQH24_RS11535 WP_000866065.1 2217680..2218432(-) (comE) [Streptococcus pneumoniae strain TVO_1901930]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATATCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408