Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA/cilD   Type   Machinery gene
Locus tag   EQH35_RS09580 Genome accession   NZ_CP035245
Coordinates   1835379..1836320 (-) Length   313 a.a.
NCBI ID   WP_000249552.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain TVO_1901943     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1830379..1841320
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH35_RS09540 (EQH35_10075) comYH 1830865..1831818 (-) 954 WP_000345099.1 class I SAM-dependent methyltransferase Machinery gene
  EQH35_RS09545 (EQH35_10080) - 1831879..1832473 (-) 595 Protein_1881 class I SAM-dependent methyltransferase -
  EQH35_RS09550 (EQH35_10085) comGG/cglG 1832610..1833023 (-) 414 WP_000265624.1 competence type IV pilus minor pilin ComGG Machinery gene
  EQH35_RS09555 (EQH35_10090) comGF/cglF 1833001..1833462 (-) 462 WP_000250542.1 competence type IV pilus minor pilin ComGF Machinery gene
  EQH35_RS09560 (EQH35_10095) comGE/cglE 1833425..1833727 (-) 303 WP_000413382.1 competence type IV pilus minor pilin ComGE Machinery gene
  EQH35_RS09565 (EQH35_10100) comGD/cglD 1833690..1834094 (-) 405 WP_000588013.1 competence type IV pilus minor pilin ComGD Machinery gene
  EQH35_RS09570 (EQH35_10105) comGC/cglC 1834087..1834413 (-) 327 WP_000738636.1 comG operon protein ComGC Machinery gene
  EQH35_RS09575 (EQH35_10110) comGB/cglB 1834415..1835431 (-) 1017 WP_074017570.1 competence type IV pilus assembly protein ComGB Machinery gene
  EQH35_RS09580 (EQH35_10115) comGA/cglA/cilD 1835379..1836320 (-) 942 WP_000249552.1 competence type IV pilus ATPase ComGA Machinery gene
  EQH35_RS09585 (EQH35_10120) - 1836396..1836761 (-) 366 WP_000286415.1 DUF1033 family protein -
  EQH35_RS09590 (EQH35_10125) - 1836912..1837970 (-) 1059 WP_000649468.1 zinc-dependent alcohol dehydrogenase family protein -
  EQH35_RS09595 (EQH35_10130) nagA 1838133..1839284 (-) 1152 WP_001134457.1 N-acetylglucosamine-6-phosphate deacetylase -
  EQH35_RS09600 (EQH35_10135) - 1839437..1841254 (-) 1818 WP_001220922.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35587.57 Da        Isoelectric Point: 6.0083

>NTDB_id=337394 EQH35_RS09580 WP_000249552.1 1835379..1836320(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain TVO_1901943]
MVQEIAQEIIRSARKKGAQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYA
YDQKMASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDIETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFANRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=337394 EQH35_RS09580 WP_000249552.1 1835379..1836320(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain TVO_1901943]
ATGGTTCAAGAAATTGCACAAGAAATCATTCGCTCGGCTCGGAAAAAAGGGGCGCAAGACATTTATTTTGTCCCCAAGTT
AGACGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGCTGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCG
TTATCAGTCACTTTAAGTTTGTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
TATGACCAGAAGATGGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGGCATGAGAGTTTGGTTATCCGTTTGTT
GCACGATGAGGAGCAGGACTTGCATTTTTGGTTTCAGGATATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCT
ATCTTTTTGCTGGTCCGGTTGGGAGTGGTAAGACGACCTTGATGCATGAATTGTCCAAGTCACTCTTTAAAGGACAGCAA
GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGACATGCTTCAGTTGCAGTTGAACGAAGCAATCGGTCTAAC
CTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCAGATCTCTTGATTATCGGAGAAATTCGTGACATCGAGACGG
CGCGTGCAGTGGTCAGAGCTAGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTCTGCTACCAGAGATTAATCGG
GGGAGGAGGAATCGTTGACTTTGCAAACAGAGATTATCAAGAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGC
TTCTTAAAGATGGACATATCACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

98.403

100

0.984
  comGA/cglA/cilD Streptococcus pneumoniae D39

98.403

100

0.984
  comGA/cglA/cilD Streptococcus pneumoniae R6

98.403

100

0.984
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

98.403

100

0.984
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

96.805

100

0.968
  comYA Streptococcus gordonii str. Challis substr. CH1

77.742

99.042

0.77
  comYA Streptococcus mutans UA159

66.238

99.361

0.658
  comYA Streptococcus mutans UA140

66.238

99.361

0.658
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

62.903

99.042

0.623
  comGA Lactococcus lactis subsp. cremoris KW2

55.128

99.681

0.55
  comGA Latilactobacillus sakei subsp. sakei 23K

41.912

86.901

0.364

Multiple sequence alignment