Detailed information NTG0337017

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EQH41_RS10815
• Genome accession: NZ_CP035239
• Coordinates: 2148467..2149219 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_TIGR4
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2143467..2154219

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH41_RS10795	-	2145901..2147503 (-)	1603	Protein_2122	YhgE/Pip family protein	-
EQH41_RS10800 (EQH41_11495)	-	2147682..2148224 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
EQH41_RS10815 (EQH41_11510)	comE	2148467..2149219 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
EQH41_RS10820 (EQH41_11515)	comD/comD2	2149216..2150541 (-)	1326	WP_000364845.1	competence system sensor histidine kinase ComD	Regulator
EQH41_RS10825 (EQH41_11520)	comC/comC2	2150562..2150687 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
EQH41_RS10835 (EQH41_11530)	rlmH	2150969..2151448 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EQH41_RS10840 (EQH41_11535)	htrA	2151631..2152812 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
EQH41_RS10845 (EQH41_11540)	spo0J	2152870..2153628 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=337017 EQH41_RS10815 WP_000866065.1 2148467..2149219(-) (comE) [Streptococcus pneumoniae strain TVO_TIGR4]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=337017 EQH41_RS10815 WP_000866065.1 2148467..2149219(-) (comE) [Streptococcus pneumoniae strain TVO_TIGR4]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGTAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408