Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   EQH44_RS09025 Genome accession   NZ_CP035236
Coordinates   1783196..1784452 (-) Length   418 a.a.
NCBI ID   WP_000642709.1    Uniprot ID   A0A0E8AGF5
Organism   Streptococcus pneumoniae strain TVO_1902282     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1776294..1798288 1783196..1784452 within 0


Gene organization within MGE regions


Location: 1776294..1798288
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH44_RS08985 (EQH44_09500) - 1776294..1776878 (-) 585 WP_001101186.1 hypothetical protein -
  EQH44_RS08990 (EQH44_09505) - 1777276..1777701 (-) 426 WP_001812209.1 hypothetical protein -
  EQH44_RS08995 (EQH44_09510) - 1777830..1778189 (-) 360 WP_000749819.1 ImmA/IrrE family metallo-endopeptidase -
  EQH44_RS09000 (EQH44_09515) - 1778235..1778441 (-) 207 WP_000366093.1 hypothetical protein -
  EQH44_RS09005 (EQH44_09520) - 1778428..1778589 (-) 162 WP_000289348.1 helix-turn-helix domain-containing protein -
  EQH44_RS09010 (EQH44_09525) lytA 1778967..1779923 (-) 957 WP_000405234.1 N-acetylmuramoyl-L-alanine amidase LytA -
  EQH44_RS09015 (EQH44_09530) - 1780299..1781669 (-) 1371 WP_001036255.1 MATE family efflux transporter -
  EQH44_RS09020 (EQH44_09540) recA 1781975..1783141 (-) 1167 WP_001085461.1 recombinase RecA Machinery gene
  EQH44_RS09025 (EQH44_09545) cinA 1783196..1784452 (-) 1257 WP_000642709.1 competence/damage-inducible protein A Machinery gene
  EQH44_RS09030 (EQH44_09550) brpA 1784537..1785553 (-) 1017 WP_000239282.1 biofilm formation/cell division transcriptional regulator BrpA -
  EQH44_RS09035 (EQH44_09555) - 1785561..1786079 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  EQH44_RS09040 (EQH44_09560) tsaE 1786069..1786512 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  EQH44_RS09045 (EQH44_09565) comM 1786598..1787218 (-) 621 WP_000839908.1 hypothetical protein Regulator
  EQH44_RS09050 (EQH44_09575) - 1787601..1788464 (-) 864 WP_001093624.1 helix-turn-helix domain-containing protein -
  EQH44_RS10755 (EQH44_09580) - 1788656..1788826 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  EQH44_RS09055 (EQH44_09585) pneA1 1788929..1789153 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  EQH44_RS09060 (EQH44_09590) pneA2 1789160..1789348 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  EQH44_RS09065 lanM 1789465..1791396 (+) 1932 WP_001812208.1 type 2 lanthipeptide synthetase LanM -
  EQH44_RS09070 - 1791446..1792456 (+) 1011 WP_001812207.1 lanthionine synthetase LanC family protein -
  EQH44_RS09075 (EQH44_09600) - 1792806..1793510 (+) 705 WP_001033170.1 flavodoxin family protein -
  EQH44_RS09080 (EQH44_09605) - 1793491..1794420 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  EQH44_RS09085 (EQH44_09610) - 1794417..1796525 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  EQH44_RS09090 (EQH44_09615) - 1796549..1798288 (+) 1740 WP_000699969.1 S8 family serine peptidase -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45075.48 Da        Isoelectric Point: 4.6064

>NTDB_id=336764 EQH44_RS09025 WP_000642709.1 1783196..1784452(-) (cinA) [Streptococcus pneumoniae strain TVO_1902282]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFKGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQEQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=336764 EQH44_RS09025 WP_000642709.1 1783196..1784452(-) (cinA) [Streptococcus pneumoniae strain TVO_1902282]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGCTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTAAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACCGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGAGCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CATATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Competence-damaged protein (CinA)

(262-414)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E8AGF5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae TIGR4

99.522

100

0.995
  cinA Streptococcus pneumoniae Rx1

99.282

100

0.993
  cinA Streptococcus pneumoniae R6

99.282

100

0.993
  cinA Streptococcus pneumoniae D39

99.043

100

0.99
  cinA Streptococcus mitis SK321

94.019

100

0.94
  cinA Streptococcus mitis NCTC 12261

93.78

100

0.938
  cinA Streptococcus mutans UA159

71.053

100

0.711
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment