Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   SPT_RS09435 Genome accession   NC_012469
Coordinates   1779542..1780798 (-) Length   418 a.a.
NCBI ID   WP_000642704.1    Uniprot ID   C1CTH7
Organism   Streptococcus pneumoniae Taiwan19F-14     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1771399..1812468 1779542..1780798 within 0


Gene organization within MGE regions


Location: 1771399..1812468
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPT_RS09385 (SPT_1889) - 1771696..1772247 (-) 552 WP_001111247.1 hypothetical protein -
  SPT_RS09390 (SPT_1890) - 1772237..1772434 (-) 198 WP_000890144.1 hypothetical protein -
  SPT_RS09395 (SPT_1891) - 1772438..1773232 (-) 795 WP_001101215.1 hypothetical protein -
  SPT_RS09400 (SPT_1892) - 1773640..1774065 (-) 426 WP_000204068.1 hypothetical protein -
  SPT_RS09405 (SPT_1893) - 1774194..1774553 (-) 360 WP_000749821.1 ImmA/IrrE family metallo-endopeptidase -
  SPT_RS09410 - 1774599..1774805 (-) 207 WP_000366087.1 hypothetical protein -
  SPT_RS09415 (SPT_1894) - 1774792..1774953 (-) 162 WP_000289348.1 helix-turn-helix domain-containing protein -
  SPT_RS09420 (SPT_1895) lytA 1775312..1776268 (-) 957 WP_000405240.1 N-acetylmuramoyl-L-alanine amidase LytA -
  SPT_RS09425 (SPT_1897) - 1776644..1778014 (-) 1371 WP_001036271.1 MATE family efflux transporter -
  SPT_RS09430 (SPT_1898) recA 1778321..1779487 (-) 1167 WP_001085462.1 recombinase RecA Machinery gene
  SPT_RS09435 (SPT_1899) cinA 1779542..1780798 (-) 1257 WP_000642704.1 competence/damage-inducible protein A Machinery gene
  SPT_RS09440 (SPT_1900) brpA 1780883..1781899 (-) 1017 WP_000239278.1 biofilm formation/cell division transcriptional regulator BrpA -
  SPT_RS09445 (SPT_1901) - 1781907..1782425 (-) 519 WP_000455536.1 GNAT family N-acetyltransferase -
  SPT_RS09450 (SPT_1902) tsaE 1782415..1782858 (-) 444 WP_000288230.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  SPT_RS09455 (SPT_1903) comM 1782944..1783564 (-) 621 WP_000839909.1 hypothetical protein Regulator
  SPT_RS09460 (SPT_1904) - 1783870..1784733 (-) 864 WP_001093609.1 helix-turn-helix domain-containing protein -
  SPT_RS13265 (SPT_1905) - 1784924..1785094 (+) 171 WP_001227863.1 PhrA family quorum-sensing system peptide -
  SPT_RS09470 (SPT_1907) - 1785496..1785810 (+) 315 WP_000420682.1 YdcP family protein -
  SPT_RS09475 (SPT_1908) - 1785826..1786212 (+) 387 WP_000985015.1 YdcP family protein -
  SPT_RS09480 (SPT_1909) - 1786241..1787626 (+) 1386 WP_000813488.1 FtsK/SpoIIIE domain-containing protein -
  SPT_RS12265 - 1787629..1787781 (+) 153 WP_000879507.1 hypothetical protein -
  SPT_RS09485 (SPT_1910) mobT 1787804..1789009 (+) 1206 WP_000398284.1 MobT family relaxase -
  SPT_RS09490 (SPT_1911) - 1789052..1789273 (+) 222 WP_001009056.1 hypothetical protein -
  SPT_RS09495 (SPT_1912) - 1789390..1789887 (+) 498 WP_000342539.1 antirestriction protein ArdA -
  SPT_RS09500 (SPT_1913) - 1789976..1790368 (+) 393 WP_000723888.1 conjugal transfer protein -
  SPT_RS09505 (SPT_1914) - 1790352..1792799 (+) 2448 WP_000331160.1 ATP-binding protein -
  SPT_RS09510 (SPT_1915) - 1792802..1794979 (+) 2178 WP_012677156.1 CD3337/EF1877 family mobilome membrane protein -
  SPT_RS09515 (SPT_1916) - 1794976..1795977 (+) 1002 WP_000769868.1 lysozyme family protein -
  SPT_RS09520 (SPT_1917) - 1795974..1796906 (+) 933 WP_001224318.1 conjugal transfer protein -
  SPT_RS13480 - 1797220..1797267 (+) 48 Protein_1810 hypothetical protein -
  SPT_RS09525 (SPT_1919) tet(M) 1797283..1799202 (+) 1920 WP_000691729.1 tetracycline resistance ribosomal protection protein Tet(M) -
  SPT_RS09535 - 1799566..1799811 (+) 246 WP_001813542.1 hypothetical protein -
  SPT_RS09540 (SPT_1922) - 1799808..1800143 (+) 336 WP_000806926.1 hypothetical protein -
  SPT_RS09545 (SPT_1923) - 1800156..1800524 (+) 369 WP_000567222.1 hypothetical protein -
  SPT_RS09550 (SPT_1924) - 1800511..1800810 (+) 300 WP_001072467.1 DUF5960 family protein -
  SPT_RS09555 (SPT_1925) msr(D) 1800928..1802391 (-) 1464 WP_000420313.1 ABC-F type ribosomal protection protein Msr(D) -
  SPT_RS09560 (SPT_1926) mef(A) 1802511..1803728 (-) 1218 WP_000417519.1 macrolide efflux MFS transporter Mef(A) -
  SPT_RS09565 (SPT_1927) - 1804114..1804284 (-) 171 WP_000873143.1 hypothetical protein -
  SPT_RS12275 - 1804806..1804997 (+) 192 WP_001860868.1 cysteine-rich KTR domain-containing protein -
  SPT_RS09575 (SPT_1928) - 1805057..1805410 (-) 354 WP_001227347.1 helix-turn-helix transcriptional regulator -
  SPT_RS09580 (SPT_1929) - 1805915..1806337 (+) 423 WP_000804885.1 sigma-70 family RNA polymerase sigma factor -
  SPT_RS09585 - 1806334..1806564 (+) 231 WP_000857133.1 helix-turn-helix domain-containing protein -
  SPT_RS13130 - 1806790..1807041 (-) 252 WP_001845478.1 hypothetical protein -
  SPT_RS09590 (SPT_1930) - 1807025..1807228 (+) 204 WP_000814511.1 excisionase -
  SPT_RS09595 (SPT_1931) - 1807310..1808527 (+) 1218 WP_001291561.1 tyrosine-type recombinase/integrase -
  SPT_RS09600 (SPT_1933) - 1809418..1811433 (+) 2016 WP_000732395.1 DUF1430 domain-containing protein -
  SPT_RS09605 (SPT_1934) - 1811435..1812067 (+) 633 WP_000571425.1 ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45089.42 Da        Isoelectric Point: 4.5211

>NTDB_id=33407 SPT_RS09435 WP_000642704.1 1779542..1780798(-) (cinA) [Streptococcus pneumoniae Taiwan19F-14]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGNKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=33407 SPT_RS09435 WP_000642704.1 1779542..1780798(-) (cinA) [Streptococcus pneumoniae Taiwan19F-14]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAACAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTGAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Competence-damaged protein (CinA)

(262-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C1CTH7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae Rx1

99.522

100

0.995
  cinA Streptococcus pneumoniae R6

99.522

100

0.995
  cinA Streptococcus pneumoniae TIGR4

99.282

100

0.993
  cinA Streptococcus pneumoniae D39

99.282

100

0.993
  cinA Streptococcus mitis SK321

93.301

100

0.933
  cinA Streptococcus mitis NCTC 12261

93.062

100

0.931
  cinA Streptococcus mutans UA159

70.813

100

0.708
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment