Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   HMPREF0837_RS10570 Genome accession   NC_014251
Coordinates   1999380..2000636 (-) Length   418 a.a.
NCBI ID   WP_000642704.1    Uniprot ID   C1CTH7
Organism   Streptococcus pneumoniae TCH8431/19A     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1994380..2005636
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF0837_RS10545 (HMPREF0837_12179) - 1994437..1994643 (-) 207 WP_000366087.1 hypothetical protein -
  HMPREF0837_RS10550 (HMPREF0837_12180) - 1994630..1994791 (-) 162 WP_000289348.1 helix-turn-helix domain-containing protein -
  HMPREF0837_RS10555 (HMPREF0837_12181) lytA 1995150..1996106 (-) 957 WP_000405240.1 N-acetylmuramoyl-L-alanine amidase LytA -
  HMPREF0837_RS10560 (HMPREF0837_12182) - 1996482..1997852 (-) 1371 WP_001036271.1 MATE family efflux transporter -
  HMPREF0837_RS10565 (HMPREF0837_12183) recA 1998159..1999325 (-) 1167 WP_001085462.1 recombinase RecA -
  HMPREF0837_RS10570 (HMPREF0837_12184) cinA 1999380..2000636 (-) 1257 WP_000642704.1 competence/damage-inducible protein A Machinery gene
  HMPREF0837_RS10575 (HMPREF0837_12185) brpA 2000721..2001737 (-) 1017 WP_000239278.1 biofilm formation/cell division transcriptional regulator BrpA -
  HMPREF0837_RS10580 (HMPREF0837_12186) - 2001745..2002263 (-) 519 WP_000455536.1 GNAT family N-acetyltransferase -
  HMPREF0837_RS10585 (HMPREF0837_12187) tsaE 2002253..2002696 (-) 444 WP_000288230.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  HMPREF0837_RS10590 (HMPREF0837_12188) comM 2002782..2003402 (-) 621 WP_000839909.1 hypothetical protein Regulator
  HMPREF0837_RS10595 (HMPREF0837_12189) - 2003708..2004571 (-) 864 WP_001093609.1 helix-turn-helix domain-containing protein -
  HMPREF0837_RS13220 (HMPREF0837_12190) - 2004762..2004932 (+) 171 WP_001227863.1 PhrA family quorum-sensing system peptide -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45089.42 Da        Isoelectric Point: 4.5211

>NTDB_id=32727 HMPREF0837_RS10570 WP_000642704.1 1999380..2000636(-) (cinA) [Streptococcus pneumoniae TCH8431/19A]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGNKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=32727 HMPREF0837_RS10570 WP_000642704.1 1999380..2000636(-) (cinA) [Streptococcus pneumoniae TCH8431/19A]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAACAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTGAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterProScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Competence-damaged protein (CinA)

(262-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C1CTH7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae R36A

99.522

100

0.995
  cinA Streptococcus pneumoniae Rx1

99.522

100

0.995
  cinA Streptococcus pneumoniae R6

99.522

100

0.995
  cinA Streptococcus pneumoniae TIGR4

99.282

100

0.993
  cinA Streptococcus pneumoniae D39

99.282

100

0.993
  cinA Streptococcus mitis SK321

93.301

100

0.933
  cinA Streptococcus mitis NCTC 12261

93.062

100

0.931
  cinA Streptococcus mutans UA159

70.813

100

0.708
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment