Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   SEZ_RS09110 Genome accession   NC_011134
Coordinates   1933711..1934982 (-) Length   423 a.a.
NCBI ID   WP_012516442.1    Uniprot ID   B4U0I9
Organism   Streptococcus equi subsp. zooepidemicus MGCS10565     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1903129..1937763 1933711..1934982 within 0
IScluster/Tn 1929355..1937763 1933711..1934982 within 0


Gene organization within MGE regions


Location: 1903129..1937763
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SEZ_RS08940 (Sez_1834) - 1903129..1903770 (+) 642 WP_012516411.1 deoxynucleoside kinase -
  SEZ_RS08945 (Sez_1835) - 1904052..1905056 (+) 1005 WP_012516412.1 hypothetical protein -
  SEZ_RS08950 (Sez_1836) - 1905107..1905910 (-) 804 WP_012516413.1 ATP-binding cassette domain-containing protein -
  SEZ_RS08955 (Sez_1837) - 1905919..1906803 (-) 885 WP_012516414.1 ABC transporter permease -
  SEZ_RS08960 (Sez_1838) - 1906913..1907875 (-) 963 WP_012516415.1 ABC transporter substrate-binding protein -
  SEZ_RS08965 (Sez_1839) - 1907902..1908867 (-) 966 WP_041785774.1 ABC transporter substrate-binding protein -
  SEZ_RS08970 (Sez_1840) - 1909273..1910226 (-) 954 WP_012514856.1 IS30 family transposase -
  SEZ_RS08975 (Sez_1841) - 1910412..1911810 (+) 1399 Protein_1724 ISNCY family transposase -
  SEZ_RS08980 (Sez_1844) ssbA 1911977..1912372 (-) 396 WP_012516417.1 single-stranded DNA-binding protein Machinery gene
  SEZ_RS08985 (Sez_1845) - 1912483..1913196 (+) 714 WP_041785777.1 class I SAM-dependent methyltransferase -
  SEZ_RS08990 (Sez_1846) ytpR 1913498..1914124 (-) 627 WP_012516419.1 YtpR family tRNA-binding protein -
  SEZ_RS08995 (Sez_1847) - 1914139..1914456 (-) 318 WP_012516420.1 thioredoxin family protein -
  SEZ_RS09000 (Sez_1848) - 1914453..1914737 (-) 285 WP_021321209.1 DUF4651 domain-containing protein -
  SEZ_RS09005 (Sez_1849) pepA 1915141..1916208 (+) 1068 WP_012516422.1 glutamyl aminopeptidase -
  SEZ_RS09010 (Sez_1850) proC 1916292..1917065 (+) 774 WP_012516423.1 pyrroline-5-carboxylate reductase -
  SEZ_RS09015 (Sez_1851) - 1917300..1917737 (-) 438 WP_012516424.1 hypothetical protein -
  SEZ_RS09020 (Sez_1852) - 1917767..1918441 (-) 675 WP_012516425.1 CPBP family intramembrane glutamic endopeptidase -
  SEZ_RS09025 (Sez_1853) - 1918451..1918903 (-) 453 WP_012516426.1 hypothetical protein -
  SEZ_RS09030 (Sez_1854) - 1918905..1919108 (-) 204 WP_012516427.1 helix-turn-helix transcriptional regulator -
  SEZ_RS09035 (Sez_1855) yaaA 1919539..1920270 (+) 732 WP_012516428.1 peroxide stress protein YaaA -
  SEZ_RS09040 (Sez_1857) nrdG 1920731..1921345 (-) 615 WP_012516430.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  SEZ_RS09045 (Sez_1858) - 1921355..1921849 (-) 495 WP_012516431.1 GNAT family N-acetyltransferase -
  SEZ_RS09050 (Sez_1859) - 1921862..1922797 (-) 936 WP_012516432.1 Gfo/Idh/MocA family oxidoreductase -
  SEZ_RS09900 (Sez_1860) - 1922825..1922971 (-) 147 WP_012516433.1 hypothetical protein -
  SEZ_RS09055 (Sez_1861) nrdD 1923077..1925275 (-) 2199 WP_012516434.1 anaerobic ribonucleoside-triphosphate reductase -
  SEZ_RS09060 (Sez_1862) - 1925371..1926906 (-) 1536 WP_012516435.1 membrane protein -
  SEZ_RS09065 (Sez_1864) - 1927482..1927781 (-) 300 WP_012516437.1 DUF1292 domain-containing protein -
  SEZ_RS09070 (Sez_1865) ruvX 1927791..1928210 (-) 420 WP_012678687.1 Holliday junction resolvase RuvX -
  SEZ_RS09075 (Sez_1866) - 1928207..1928476 (-) 270 WP_012516439.1 IreB family regulatory phosphoprotein -
  SEZ_RS09080 (Sez_1867) spx 1928589..1928987 (-) 399 WP_012516440.1 transcriptional regulator Spx -
  SEZ_RS09760 - 1929355..1930926 (-) 1572 Protein_1747 IS3 family transposase -
  SEZ_RS09100 (Sez_1872) - 1931001..1932343 (+) 1343 WP_165626751.1 IS3 family transposase -
  SEZ_RS09105 (Sez_1873) recA 1932481..1933617 (-) 1137 WP_012516441.1 recombinase RecA Machinery gene
  SEZ_RS09110 (Sez_1874) cinA 1933711..1934982 (-) 1272 WP_012516442.1 competence/damage-inducible protein A Machinery gene
  SEZ_RS09115 (Sez_1875) - 1935668..1935958 (-) 291 WP_012516443.1 hypothetical protein -
  SEZ_RS09120 (Sez_1876) - 1935952..1936524 (-) 573 WP_012516444.1 phosphlipase A2 SlaA -
  SEZ_RS09125 (Sez_1877) - 1936810..1937763 (+) 954 WP_012516445.1 IS30 family transposase -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45705.39 Da        Isoelectric Point: 6.0754

>NTDB_id=31403 SEZ_RS09110 WP_012516442.1 1933711..1934982(-) (cinA) [Streptococcus equi subsp. zooepidemicus MGCS10565]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVIDIASQRSDLVILCGGLGPTDDDLTKQT
LAKYLGKALVFDEQAGQKLDTFFAHRKHTARTPNNQRQAQLIEGSVALQNQTGLAVGGLITVDGVTYVVLPGPPSELKPM
VKNELVPLLSASHASLYSRVLRFFGIGESQLVTALEDLIKHQTDPTIAPYAKTGEVTLRLSTKADNQALADERLNRLEAQ
LLSIRTVDNQPLRRLLYGYGEDNSLARETFELLKRSGKTITAAESLTAGLFQAQLTDFAGASQVFNGGFITYSIEEKAKM
LGIPLVELQRHGVVSSFTAEQMAAQARCLTNSDIGIGLTGVAGPEALEGQPAGTVFIGLATKNKVESLKVVIGGRSRLDV
RYIAALYAFNMVRKALLKSENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=31403 SEZ_RS09110 WP_012516442.1 1933711..1934982(-) (cinA) [Streptococcus equi subsp. zooepidemicus MGCS10565]
ATGAAAGCTGAACTCATTGCGGTGGGAACCGAGATTCTGACTGGTCAGATTGTGAATACCAATGCTCAATTTTTATCAGA
AAAAATGGCAGAGCTTGGCATTGATGTTTATTTTCAAACAGCTGTAGGAGATAATGAAGAGCGTTTGCTTTCTGTTATTG
ATATTGCTAGCCAGCGAAGTGATTTAGTGATTTTATGTGGTGGTCTTGGTCCAACAGATGATGATCTAACGAAGCAGACC
TTAGCTAAGTATCTGGGAAAAGCTTTGGTCTTTGATGAGCAGGCAGGTCAAAAATTAGATACTTTTTTTGCACATCGTAA
GCATACTGCTAGGACACCAAACAACCAACGTCAGGCGCAGCTGATTGAAGGCTCTGTTGCTTTGCAAAATCAAACAGGAC
TTGCAGTAGGTGGCTTGATCACTGTAGATGGGGTAACCTATGTTGTCTTACCAGGGCCTCCAAGTGAGTTAAAGCCTATG
GTAAAAAATGAGCTGGTACCCCTTCTTTCAGCTAGTCACGCTAGTCTGTACTCAAGAGTGCTGCGCTTTTTTGGCATTGG
TGAGAGTCAACTGGTGACTGCTCTGGAGGATTTGATTAAGCATCAAACAGATCCTACTATTGCTCCTTATGCAAAGACCG
GCGAGGTAACACTGCGACTATCCACAAAGGCTGACAACCAAGCATTAGCTGATGAAAGGCTGAATCGACTAGAGGCGCAG
CTCTTATCCATAAGAACTGTAGATAATCAACCCTTACGGCGTTTGCTTTATGGCTATGGGGAGGATAATTCCTTGGCGCG
TGAGACCTTTGAGTTATTGAAGCGAAGTGGTAAGACGATAACAGCAGCTGAAAGCTTAACAGCAGGACTGTTTCAGGCTC
AGCTAACTGATTTTGCGGGAGCTTCACAGGTGTTTAACGGTGGCTTTATCACCTACAGCATTGAAGAAAAAGCAAAAATG
CTTGGCATTCCATTGGTTGAGCTACAAAGGCATGGTGTTGTGAGCTCTTTCACAGCTGAGCAAATGGCTGCGCAGGCACG
CTGCTTGACCAATTCGGATATCGGTATTGGTCTAACAGGTGTTGCTGGCCCAGAGGCACTTGAGGGACAGCCAGCAGGAA
CAGTTTTCATTGGCCTTGCCACTAAGAATAAGGTAGAATCTCTTAAAGTTGTTATAGGAGGCCGTAGCCGTTTGGACGTG
CGGTATATTGCTGCCCTATATGCTTTTAATATGGTTCGTAAAGCTTTATTAAAATCAGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-416)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-241)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B4U0I9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

70.449

100

0.704
  cinA Streptococcus mitis NCTC 12261

70.983

98.582

0.7
  cinA Streptococcus mitis SK321

70.983

98.582

0.7
  cinA Streptococcus pneumoniae TIGR4

70.024

98.582

0.69
  cinA Streptococcus pneumoniae Rx1

70.024

98.582

0.69
  cinA Streptococcus pneumoniae R6

70.024

98.582

0.69
  cinA Streptococcus pneumoniae D39

69.784

98.582

0.688
  cinA Streptococcus suis isolate S10

54.177

99.054

0.537
  cinA Bacillus subtilis subsp. subtilis str. 168

48.086

98.818

0.475

Multiple sequence alignment