Detailed information NTG0303334

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ETT46_RS01465
• Genome accession: NZ_CP035453
• Coordinates: 248118..248858 (+)
• Length: 246 a.a.
• NCBI ID: WP_011528222.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm100
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 243118..253858

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT46_RS01450 (ETT46_01450)	gltX	243648..245093 (+)	1446	WP_136265262.1	glutamate--tRNA ligase	-
ETT46_RS01455 (ETT46_01455)	-	245488..246834 (+)	1347	WP_023610780.1	sensor histidine kinase	-
ETT46_RS01460 (ETT46_01460)	-	246831..248114 (+)	1284	WP_136110989.1	sensor histidine kinase	-
ETT46_RS01465 (ETT46_01465)	comE/blpR	248118..248858 (+)	741	WP_011528222.1	LytTR family DNA-binding domain-containing protein	Regulator
ETT46_RS01470 (ETT46_01470)	rnpA	249398..249757 (+)	360	WP_002992035.1	ribonuclease P protein component	-
ETT46_RS01475 (ETT46_01475)	-	249723..250550 (+)	828	WP_010921871.1	YidC/Oxa1 family membrane protein insertase	-
ETT46_RS01480 (ETT46_01480)	jag	250562..251476 (+)	915	WP_014407283.1	RNA-binding cell elongation regulator Jag/EloR	-
ETT46_RS01485 (ETT46_01485)	rpmH	251790..251924 (+)	135	WP_002885866.1	50S ribosomal protein L34	-
ETT46_RS01490 (ETT46_01490)	-	252198..252902 (+)	705	WP_011528225.1	N-acetylmannosamine-6-phosphate 2-epimerase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28909.53 Da
• Isoelectric Point: 6.8298

>NTDB_id=303334 ETT46_RS01465 WP_011528222.1 248118..248858(+) (comE/blpR) [Streptococcus pyogenes strain emm100]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTRTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=303334 ETT46_RS01465 WP_011528222.1 248118..248858(+) (comE/blpR) [Streptococcus pyogenes strain emm100]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCCGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCGGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGCAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGCATTG
ATAAAAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGATTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCTCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.903	100	0.382
comE/comE2	Streptococcus gordonii strain NCTC7865	37.903	100	0.382
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37