Detailed information NTG0301440

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ETT66_RS01245
• Genome accession: NZ_CP035433
• Coordinates: 222801..223541 (+)
• Length: 246 a.a.
• NCBI ID: WP_002992034.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm65
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 217801..228541

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT66_RS01230 (ETT66_01230)	gltX	218331..219776 (+)	1446	WP_136286559.1	glutamate--tRNA ligase	-
ETT66_RS01235 (ETT66_01235)	-	220171..221517 (+)	1347	WP_002991186.1	sensor histidine kinase	-
ETT66_RS01240 (ETT66_01240)	-	221514..222797 (+)	1284	WP_136286561.1	sensor histidine kinase	-
ETT66_RS01245 (ETT66_01245)	comE/blpR	222801..223541 (+)	741	WP_002992034.1	LytTR family DNA-binding domain-containing protein	Regulator
ETT66_RS01250 (ETT66_01250)	rnpA	224081..224440 (+)	360	WP_002992035.1	ribonuclease P protein component	-
ETT66_RS01255 (ETT66_01255)	-	224406..225233 (+)	828	WP_002991181.1	YidC/Oxa1 family membrane protein insertase	-
ETT66_RS01260 (ETT66_01260)	jag	225245..226159 (+)	915	WP_136019779.1	RNA-binding cell elongation regulator Jag/EloR	-
ETT66_RS01265 (ETT66_01265)	rpmH	226474..226608 (+)	135	WP_002885866.1	50S ribosomal protein L34	-
ETT66_RS01270 (ETT66_01270)	-	226882..227586 (+)	705	WP_136026398.1	N-acetylmannosamine-6-phosphate 2-epimerase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28809.41 Da
• Isoelectric Point: 6.8291

>NTDB_id=301440 ETT66_RS01245 WP_002992034.1 222801..223541(+) (comE/blpR) [Streptococcus pyogenes strain emm65]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKGQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=301440 ETT66_RS01245 WP_002992034.1 222801..223541(+) (comE/blpR) [Streptococcus pyogenes strain emm65]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCCGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGGACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCAGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAAATTCAAGCAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTGTCACGATTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCCCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-120)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	42.017	96.748	0.407
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.903	100	0.382
comE/comE2	Streptococcus gordonii strain NCTC7865	37.903	100	0.382
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37