Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   LPEG9_RS04620 Genome accession   NZ_CP029546
Coordinates   850095..851336 (+) Length   413 a.a.
NCBI ID   WP_016387106.1    Uniprot ID   A0A422ME13
Organism   Lacticaseibacillus paracasei strain EG9     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 812641..862417 850095..851336 within 0


Gene organization within MGE regions


Location: 812641..862417
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LPEG9_RS04420 (LPEG9_04420) - 812641..813561 (-) 921 WP_096835977.1 IS30 family transposase -
  LPEG9_RS04425 (LPEG9_04425) - 813672..814733 (+) 1062 Protein_786 hypothetical protein -
  LPEG9_RS04430 (LPEG9_04430) - 814762..815187 (+) 426 WP_109990101.1 DUF1617 family protein -
  LPEG9_RS04435 (LPEG9_04435) - 815190..815459 (+) 270 WP_109990102.1 hypothetical protein -
  LPEG9_RS04440 (LPEG9_04440) - 815505..815798 (+) 294 WP_109990103.1 hypothetical protein -
  LPEG9_RS04445 (LPEG9_04445) - 815788..816222 (+) 435 WP_109990104.1 phage holin -
  LPEG9_RS04450 (LPEG9_04450) - 816222..816410 (+) 189 WP_012491267.1 phage holin, LLH family -
  LPEG9_RS04455 (LPEG9_04455) - 816397..817371 (+) 975 WP_109990105.1 peptidoglycan amidohydrolase family protein -
  LPEG9_RS04460 (LPEG9_04460) - 817892..819403 (+) 1512 WP_109990106.1 glycosyltransferase -
  LPEG9_RS04465 (LPEG9_04465) - 819431..820990 (+) 1560 WP_003593829.1 glycosyltransferase -
  LPEG9_RS04470 (LPEG9_04470) - 821087..821560 (+) 474 WP_003564137.1 glutathione peroxidase -
  LPEG9_RS04475 (LPEG9_04475) - 821905..823110 (+) 1206 WP_003583932.1 MalY/PatB family protein -
  LPEG9_RS04480 (LPEG9_04480) - 823244..824572 (-) 1329 WP_016387113.1 metallophosphoesterase -
  LPEG9_RS04485 (LPEG9_04485) - 824762..825028 (+) 267 WP_003564140.1 ACT domain-containing protein -
  LPEG9_RS04490 (LPEG9_04490) - 825077..826420 (+) 1344 WP_003574245.1 PFL family protein -
  LPEG9_RS04495 (LPEG9_04495) - 826530..827585 (+) 1056 WP_003593835.1 competence protein CoiA -
  LPEG9_RS04500 (LPEG9_04500) - 827775..828410 (-) 636 WP_003564143.1 DsbA family protein -
  LPEG9_RS04505 (LPEG9_04505) - 828480..829073 (-) 594 WP_003564144.1 CYTH domain-containing protein -
  LPEG9_RS04510 (LPEG9_04510) - 829267..829938 (+) 672 WP_003564145.1 GTP pyrophosphokinase family protein -
  LPEG9_RS04515 (LPEG9_04515) - 829940..830737 (+) 798 WP_003564146.1 NAD kinase -
  LPEG9_RS04520 (LPEG9_04520) - 830737..831639 (+) 903 WP_003564147.1 RluA family pseudouridine synthase -
  LPEG9_RS04525 (LPEG9_04525) - 831748..832806 (-) 1059 WP_003569478.1 FAD:protein FMN transferase -
  LPEG9_RS04530 (LPEG9_04530) - 832963..833598 (-) 636 WP_003569480.1 copper homeostasis protein CutC -
  LPEG9_RS04535 (LPEG9_04535) - 833620..834438 (-) 819 WP_003564150.1 undecaprenyl-diphosphate phosphatase -
  LPEG9_RS04540 (LPEG9_04540) - 834657..835655 (+) 999 WP_003601683.1 IS30 family transposase -
  LPEG9_RS04545 (LPEG9_04545) - 835760..836800 (-) 1041 WP_003564151.1 lactonase family protein -
  LPEG9_RS04550 (LPEG9_04550) - 837072..837449 (+) 378 WP_003593849.1 PTS glucitol/sorbitol transporter subunit IIA -
  LPEG9_RS04555 (LPEG9_04555) rpsN 837562..837831 (-) 270 WP_003564153.1 30S ribosomal protein S14 -
  LPEG9_RS04560 (LPEG9_04560) - 837959..838936 (-) 978 WP_032674946.1 GMP reductase -
  LPEG9_RS04565 (LPEG9_04565) - 839176..840123 (-) 948 WP_003564155.1 magnesium transporter CorA family protein -
  LPEG9_RS04570 (LPEG9_04570) - 840189..841031 (+) 843 WP_003569501.1 methyltransferase domain-containing protein -
  LPEG9_RS04580 (LPEG9_04580) trmL 841286..841795 (+) 510 WP_003564157.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
  LPEG9_RS04585 (LPEG9_04585) - 841922..842332 (+) 411 WP_003564159.1 DUF1149 family protein -
  LPEG9_RS04590 (LPEG9_04590) - 842505..844826 (+) 2322 WP_016365284.1 DNA translocase FtsK -
  LPEG9_RS04595 (LPEG9_04595) yfmF 844835..846097 (+) 1263 WP_109990107.1 EF-P 5-aminopentanol modification-associated protein YfmF -
  LPEG9_RS04600 (LPEG9_04600) yfmH 846094..847386 (+) 1293 WP_003661348.1 EF-P 5-aminopentanol modification-associated protein YfmH -
  LPEG9_RS04605 (LPEG9_04605) ymfI 847386..848114 (+) 729 WP_003569514.1 elongation factor P 5-aminopentanone reductase -
  LPEG9_RS04610 (LPEG9_04610) - 848201..849130 (+) 930 WP_016387107.1 helix-turn-helix domain-containing protein -
  LPEG9_RS04615 (LPEG9_04615) pgsA 849127..849720 (+) 594 WP_003564171.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  LPEG9_RS04620 (LPEG9_04620) cinA 850095..851336 (+) 1242 WP_016387106.1 competence/damage-inducible protein A Machinery gene
  LPEG9_RS04625 (LPEG9_04625) recA 851393..852454 (+) 1062 WP_003598111.1 recombinase RecA Machinery gene
  LPEG9_RS04630 (LPEG9_04630) rny 852756..854327 (+) 1572 WP_003657913.1 ribonuclease Y -
  LPEG9_RS04635 (LPEG9_04635) - 854421..855071 (-) 651 WP_003593868.1 YigZ family protein -
  LPEG9_RS04640 (LPEG9_04640) - 855099..856361 (+) 1263 WP_109990476.1 helicase-related protein -
  LPEG9_RS04645 (LPEG9_04645) - 856574..857035 (+) 462 WP_003583965.1 ComF family protein -
  LPEG9_RS04650 (LPEG9_04650) hpf 857159..857716 (+) 558 WP_003569531.1 ribosome hibernation-promoting factor, HPF/YfiA family -
  LPEG9_RS04660 (LPEG9_04660) secA 858050..860413 (+) 2364 WP_003593872.1 preprotein translocase subunit SecA -
  LPEG9_RS04665 (LPEG9_04665) prfB 860538..861654 (+) 1117 WP_096772597.1 peptide chain release factor 2 -
  LPEG9_RS04670 (LPEG9_04670) ftsE 861731..862417 (+) 687 WP_003564191.1 cell division ATP-binding protein FtsE -

Sequence

Protein


Download         Length: 413 a.a.        Molecular weight: 44312.66 Da        Isoelectric Point: 6.0028

>NTDB_id=293400 LPEG9_RS04620 WP_016387106.1 850095..851336(+) (cinA) [Lacticaseibacillus paracasei strain EG9]
MQAEIIAVGTEILMGQITNTNGAYMAKQLTALGIDSYHQQVVGDNGPRLEEAIKLAESRSNLVILIGGLGPTPDDLTKQT
LAAHLNRKLVEDPDAMAKLQARVKQQQRPMTPNNQLQAMYPEGADILVNRVGLAVGAWIVNGQHTYVLLPGPPKEFVPMV
DHELLPRLAKWSGHAEIMVSRVLRFFGIGESQLVTDLDDLIANQTDPTIATYIKDHEVTVRVTASGATEKDADAKLEPMI
GAIMDRDGQYFYGYGDDNSLAKEVVKTLAANDMQITAAESLTAGAFQAALGDVPGVSTYFKGGFVTYSLATKAAFLAIDA
RELAAHGVVSAFTAKAMAEHARRKAAADISVSFTGVAGPDTLEGQPAGTVWIGLARRGQLPEAHVYHFPGGRNDVRQRAV
MTGMMLALRALQA

Nucleotide


Download         Length: 1242 bp        

>NTDB_id=293400 LPEG9_RS04620 WP_016387106.1 850095..851336(+) (cinA) [Lacticaseibacillus paracasei strain EG9]
ATGCAAGCAGAGATTATTGCTGTCGGGACAGAGATCCTGATGGGACAGATTACTAACACAAATGGTGCCTATATGGCTAA
GCAACTGACAGCACTGGGTATTGATAGCTACCATCAACAGGTGGTGGGAGACAACGGGCCGCGACTTGAGGAGGCCATTA
AGTTGGCGGAAAGTCGCAGTAATTTAGTTATTTTGATTGGCGGGTTAGGACCGACACCAGATGATCTGACCAAGCAAACA
TTGGCAGCGCACTTGAACCGCAAATTGGTTGAAGATCCTGACGCTATGGCTAAATTACAGGCGCGCGTCAAGCAACAGCA
GCGGCCAATGACGCCTAATAATCAATTACAGGCCATGTATCCGGAAGGCGCCGATATTTTGGTCAATCGGGTTGGCTTAG
CGGTTGGCGCGTGGATCGTCAATGGGCAGCACACCTATGTCTTATTGCCGGGACCACCGAAGGAATTCGTTCCGATGGTT
GATCATGAACTGCTGCCGCGGCTAGCAAAATGGAGCGGCCACGCGGAAATTATGGTCAGCCGGGTCTTACGTTTCTTTGG
CATTGGCGAATCGCAACTAGTGACAGATCTGGACGACTTGATTGCCAACCAAACCGATCCGACCATTGCAACTTATATCA
AGGATCATGAGGTGACGGTGCGCGTCACTGCCAGTGGCGCTACCGAAAAAGACGCTGATGCAAAGTTAGAACCAATGATC
GGTGCCATCATGGATCGTGATGGTCAATATTTTTACGGCTACGGTGACGACAATAGTTTGGCAAAAGAGGTTGTGAAGAC
GCTTGCGGCAAATGATATGCAAATTACTGCAGCTGAGAGTTTGACTGCTGGCGCATTTCAAGCAGCGTTAGGCGATGTGC
CGGGGGTATCCACTTATTTTAAGGGCGGTTTTGTCACTTACTCACTTGCAACAAAGGCCGCTTTTTTGGCAATTGATGCT
CGCGAATTAGCGGCACACGGAGTTGTCAGCGCATTTACAGCCAAGGCGATGGCTGAACATGCTCGGCGTAAGGCAGCGGC
GGATATAAGTGTCAGCTTTACCGGCGTTGCCGGTCCAGACACGCTGGAAGGACAGCCTGCTGGTACGGTTTGGATCGGTT
TAGCGCGGCGCGGCCAACTGCCTGAAGCACATGTTTACCATTTTCCTGGCGGTCGCAATGATGTTCGGCAGCGTGCTGTG
ATGACTGGTATGATGCTTGCATTAAGGGCGCTGCAGGCCTAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Damage-inducible protein CinA KH domain (CinA_KH)

(180-253)

Competence-damaged protein (CinA)

(258-410)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A422ME13

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mitis NCTC 12261

52.123

100

0.535
  cinA Streptococcus mitis SK321

52.009

100

0.533
  cinA Streptococcus pneumoniae TIGR4

51.651

100

0.53
  cinA Streptococcus pneumoniae R6

51.179

100

0.525
  cinA Streptococcus pneumoniae Rx1

51.179

100

0.525
  cinA Streptococcus mutans UA159

52.415

100

0.525
  cinA Streptococcus pneumoniae D39

50.943

100

0.523
  cinA Bacillus subtilis subsp. subtilis str. 168

44.769

99.516

0.446
  cinA Streptococcus suis isolate S10

42.328

91.525

0.387

Multiple sequence alignment