Detailed information NTG0284824

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: EGX80_RS06120
• Genome accession: NZ_CP033815
• Coordinates: 1143630..1144370 (+)
• Length: 246 a.a.
• NCBI ID: WP_080277139.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain FDAARGOS_514
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1138630..1149370

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EGX80_RS06105 (EGX80_06120)	gltX	1139164..1140609 (+)	1446	WP_032463327.1	glutamate--tRNA ligase	-
EGX80_RS06110 (EGX80_06125)	-	1141004..1142350 (+)	1347	WP_002991186.1	sensor histidine kinase	-
EGX80_RS06115 (EGX80_06130)	-	1142347..1143626 (+)	1280	Protein_1135	sensor histidine kinase	-
EGX80_RS06120 (EGX80_06135)	comE/blpR	1143630..1144370 (+)	741	WP_080277139.1	LytTR family DNA-binding domain-containing protein	Regulator
EGX80_RS06125 (EGX80_06140)	rnpA	1144910..1145269 (+)	360	WP_002992035.1	ribonuclease P protein component	-
EGX80_RS06130 (EGX80_06145)	-	1145235..1146062 (+)	828	WP_010921871.1	YidC/Oxa1 family membrane protein insertase	-
EGX80_RS06135 (EGX80_06150)	jag	1146074..1146988 (+)	915	WP_011054164.1	RNA-binding cell elongation regulator Jag/EloR	-
EGX80_RS06140 (EGX80_06155)	rpmH	1147303..1147437 (+)	135	WP_002885866.1	50S ribosomal protein L34	-
EGX80_RS06145 (EGX80_06160)	-	1147711..1148415 (+)	705	WP_002991176.1	N-acetylmannosamine-6-phosphate 2-epimerase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28909.53 Da
• Isoelectric Point: 6.4841

>NTDB_id=284824 EGX80_RS06120 WP_080277139.1 1143630..1144370(+) (comE/blpR) [Streptococcus pyogenes strain FDAARGOS_514]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEVLR

Nucleotide

• Length: 741 bp

>NTDB_id=284824 EGX80_RS06120 WP_080277139.1 1143630..1144370(+) (comE/blpR) [Streptococcus pyogenes strain FDAARGOS_514]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCCGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCAGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGCAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGGTTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGTCCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	38.115	99.187	0.378
comE/comE2	Streptococcus gordonii strain NCTC7865	38.115	99.187	0.378
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37