Detailed information    

insolico Bioinformatically predicted

Overview

Name   micB   Type   Regulator
Locus tag   SM12261_RS05295 Genome accession   NZ_CP028414
Coordinates   1021864..1023222 (-) Length   452 a.a.
NCBI ID   WP_000571163.1    Uniprot ID   -
Organism   Streptococcus mitis NCTC 12261     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1016864..1028222
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SM12261_RS05265 (SM12261_1026) - 1017538..1019256 (+) 1719 WP_000121686.1 phospho-sugar mutase -
  SM12261_RS05270 (SM12261_1027) - 1019368..1019715 (+) 348 WP_000434630.1 thiol reductase thioredoxin -
  SM12261_RS05275 (SM12261_1028) - 1019753..1020430 (-) 678 WP_000566125.1 potassium channel family protein -
  SM12261_RS05280 (SM12261_1029) - 1020473..1020727 (-) 255 WP_004239453.1 type II toxin-antitoxin system RelE family toxin -
  SM12261_RS05285 (SM12261_1030) relB 1020729..1020971 (-) 243 WP_000208079.1 type II toxin-antitoxin system RelB family antitoxin -
  SM12261_RS05290 (SM12261_1031) vicX 1021062..1021871 (-) 810 WP_000004960.1 MBL fold metallo-hydrolase Regulator
  SM12261_RS05295 (SM12261_1032) micB 1021864..1023222 (-) 1359 WP_000571163.1 cell wall metabolism sensor histidine kinase VicK Regulator
  SM12261_RS05300 (SM12261_1033) micA 1023215..1023922 (-) 708 WP_000722072.1 response regulator YycF Regulator
  SM12261_RS05305 (SM12261_1034) mutY 1023978..1025153 (-) 1176 WP_000886130.1 A/G-specific adenine glycosylase -
  SM12261_RS05315 (SM12261_1035) pta 1025342..1026316 (-) 975 WP_000451571.1 phosphate acetyltransferase -
  SM12261_RS05320 (SM12261_1036) - 1026360..1027256 (-) 897 WP_001209983.1 RluA family pseudouridine synthase -
  SM12261_RS05325 (SM12261_1037) - 1027253..1028071 (-) 819 WP_000799056.1 NAD kinase -

Sequence

Protein


Download         Length: 452 a.a.        Molecular weight: 51852.38 Da        Isoelectric Point: 4.7639

>NTDB_id=284643 SM12261_RS05295 WP_000571163.1 1021864..1023222(-) (micB) [Streptococcus mitis NCTC 12261]
MIELIRKNILTSDFIFILILLGFILIVTLLLLENRRDNIRLKQINQKVKDLIAGDYSQVLDMQGSSEITNITNNLNDLSE
VIRLTQENLEQESKRLHSILSYMTDGVLATNRRGKITMINDMAKKQLGVQKEDVLNKSILELLKIEDEYELRDLITQVPE
LMIDSQDANGEYLSLRVRFALVRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALS
EPVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMRGSDEEKKYELVRDYPITSVW
IEIDTDKMTQVIDNILNNAIKYSPDGGKITVTMKTTDDQMILSISDQGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHNGFIWAKSIYGKGSTFTIVLPYDKDAVKEEVWEDEIEDQNE

Nucleotide


Download         Length: 1359 bp        

>NTDB_id=284643 SM12261_RS05295 WP_000571163.1 1021864..1023222(-) (micB) [Streptococcus mitis NCTC 12261]
ATGATTGAATTGATTAGAAAAAATATTCTTACTAGTGATTTTATCTTCATTTTAATTTTATTGGGTTTTATCTTGATTGT
TACCTTGCTTTTGCTAGAAAATCGGCGAGATAATATTCGGTTGAAGCAAATTAATCAAAAAGTTAAAGACTTGATTGCAG
GAGATTATTCTCAGGTATTGGATATGCAGGGAAGCTCTGAAATCACTAATATTACCAATAATCTCAATGATTTATCAGAA
GTAATCCGTTTGACCCAAGAAAATCTGGAACAAGAGAGTAAACGATTGCACAGTATCCTCTCTTACATGACAGATGGAGT
CCTCGCGACCAATCGTCGTGGTAAGATTACTATGATTAATGACATGGCTAAGAAACAGCTAGGTGTTCAGAAGGAAGATG
TTCTCAATAAAAGTATTCTAGAATTACTTAAGATTGAAGATGAGTATGAACTTCGTGATTTGATTACCCAAGTTCCTGAA
CTCATGATTGATTCTCAGGATGCCAATGGTGAGTATCTGAGCCTTCGTGTACGCTTCGCCTTGGTGCGTCGTGAGTCTGG
ATTTATCTCAGGTTTGGTAGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTT
CCAACGTTAGTCATGAGTTACGGACGCCTCTGACTAGTGTAAAATCCTATCTTGAAGCCTTGGATGAGGGAGCCTTGTCA
GAACCTGTTGCACCAGACTTTATCAAGGTGTCTCTAGACGAAACCAACCGTATGATGCGGATGGTGACAGACCTTCTCCA
TCTTTCTCGAATTGATAATGCAACTAGTCACCTAGATGTGGAACTGATTAACTTCACAGCCTTTATTACCTTTATTCTTA
ACCGCTTTGATAAGATGAGGGGATCAGACGAAGAAAAGAAATATGAATTGGTTAGAGATTATCCGATTACGTCTGTCTGG
ATTGAAATTGATACAGACAAGATGACGCAGGTGATTGATAATATTCTCAACAATGCCATTAAATATTCTCCAGATGGTGG
AAAAATCACAGTGACCATGAAGACGACTGATGATCAGATGATTTTATCCATCTCAGACCAAGGATTGGGTATTCCTAAGC
AGGATTTGCCACGTATCTTTGACCGTTTCTACCGTGTGGATCGTGCTAGAAGCCGTGCTCAAGGTGGAACAGGGCTAGGA
CTGTCTATCGCTAAAGAAATTATCAAACAACATAATGGTTTTATTTGGGCCAAGAGTATATATGGTAAGGGATCAACCTT
TACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAGGAAGAAGTATGGGAGGACGAAATAGAAGACCAGAATGAGTGA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-434)

PAS fold (PAS)

(95-198)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micB Streptococcus pneumoniae Cp1015

89.977

97.124

0.874
  vicK Streptococcus mutans UA159

71.642

88.938

0.637

Multiple sequence alignment