Detailed information NTG0284644

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: SM12261_RS05300
• Genome accession: NZ_CP028414
• Coordinates: 1023215..1023922 (-)
• Length: 235 a.a.
• NCBI ID: WP_000722072.1
• Uniprot ID: A0A3R9LLL2
• Organism: Streptococcus mitis NCTC 12261
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1018215..1028922

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SM12261_RS05270 (SM12261_1027)	-	1019368..1019715 (+)	348	WP_000434630.1	thiol reductase thioredoxin	-
SM12261_RS05275 (SM12261_1028)	-	1019753..1020430 (-)	678	WP_000566125.1	potassium channel family protein	-
SM12261_RS05280 (SM12261_1029)	-	1020473..1020727 (-)	255	WP_004239453.1	type II toxin-antitoxin system RelE family toxin	-
SM12261_RS05285 (SM12261_1030)	relB	1020729..1020971 (-)	243	WP_000208079.1	type II toxin-antitoxin system RelB family antitoxin	-
SM12261_RS05290 (SM12261_1031)	vicX	1021062..1021871 (-)	810	WP_000004960.1	MBL fold metallo-hydrolase	Regulator
SM12261_RS05295 (SM12261_1032)	micB	1021864..1023222 (-)	1359	WP_000571163.1	cell wall metabolism sensor histidine kinase VicK	Regulator
SM12261_RS05300 (SM12261_1033)	micA	1023215..1023922 (-)	708	WP_000722072.1	response regulator YycF	Regulator
SM12261_RS05305 (SM12261_1034)	mutY	1023978..1025153 (-)	1176	WP_000886130.1	A/G-specific adenine glycosylase	-
SM12261_RS05315 (SM12261_1035)	pta	1025342..1026316 (-)	975	WP_000451571.1	phosphate acetyltransferase	-
SM12261_RS05320 (SM12261_1036)	-	1026360..1027256 (-)	897	WP_001209983.1	RluA family pseudouridine synthase	-
SM12261_RS05325 (SM12261_1037)	-	1027253..1028071 (-)	819	WP_000799056.1	NAD kinase	-
SM12261_RS05330 (SM12261_1038)	-	1028055..1028726 (-)	672	WP_000171692.1	GTP pyrophosphokinase	-

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27107.90 Da
• Isoelectric Point: 4.6177

>NTDB_id=284644 SM12261_RS05300 WP_000722072.1 1023215..1023922(-) (micA) [Streptococcus mitis NCTC 12261]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPIIMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRTDLVSVDNQESDEKKTQPLQIGDLEIVPDAYVAKKYGEELDL
THREFELLYHLASHIGQVITREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMRNND

Nucleotide

• Length: 708 bp

>NTDB_id=284644 SM12261_RS05300 WP_000722072.1 1023215..1023922(-) (micA) [Streptococcus mitis NCTC 12261]
ATGAAAAAAATATTAATTGTAGATGATGAAAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
GGTTGTAACTGCTTTTAATGGTCGTGAAGCACTAGAACAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCCGAAATTGATGGTTTAGAAGTTGCAAAGACTATTCGTAAGACGAGTAGTGTTCCTATTATCATGCTGTCAGCT
AAAGACAGCGAATTTGATAAGGTTATTGGTTTGGAGCTTGGAGCGGATGACTATGTGACAAAACCCTTCTCAAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTTCGTCGTACGGACTTGGTTTCTGTAGATAATCAAGAGTCAGATGAAAAGAAAA
CCCAACCTTTGCAAATTGGGGACTTGGAGATTGTACCAGATGCCTATGTGGCTAAAAAATATGGTGAAGAACTAGACTTG
ACCCACCGTGAATTTGAACTTTTGTACCACTTGGCTTCTCATATTGGTCAAGTGATTACCCGTGAACACTTGCTTGAAAC
GGTCTGGGGGTATGATTATTTCGGAGATGTTCGGACTGTTGACGTAACTATCAGACGTTTGCGTGAGAAGATTGAAGATA
CACCTAGTCGTCCAGAGTATATCCTAACACGTCGTGGTGTTGGTTATTATATGAGAAATAATGATTGA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (155-230)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A3R9LLL2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	94.017	99.574	0.936
vicR	Streptococcus mutans UA159	77.447	100	0.774
covR	Streptococcus salivarius strain HSISS4	44.589	98.298	0.438
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.723	98.298	0.43
scnR	Streptococcus mutans UA159	38.034	99.574	0.379