Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   C7K40_RS08985 Genome accession   NZ_CP027771
Coordinates   1785784..1787055 (-) Length   423 a.a.
NCBI ID   WP_023612670.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain DMG1800716     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1774739..1803932 1785784..1787055 within 0


Gene organization within MGE regions


Location: 1774739..1803932
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C7K40_RS08925 (C7K40_08920) nrdG 1774739..1775353 (-) 615 WP_002982219.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  C7K40_RS08930 (C7K40_08925) - 1775353..1775862 (-) 510 WP_011285262.1 GNAT family N-acetyltransferase -
  C7K40_RS08935 (C7K40_08930) - 1775871..1776806 (-) 936 WP_002992828.1 Gfo/Idh/MocA family oxidoreductase -
  C7K40_RS09530 - 1776835..1776981 (-) 147 WP_002982210.1 hypothetical protein -
  C7K40_RS08940 (C7K40_08935) nrdD 1777163..1779361 (-) 2199 WP_002982204.1 anaerobic ribonucleoside-triphosphate reductase -
  C7K40_RS08945 (C7K40_08940) - 1779458..1781017 (-) 1560 WP_023613027.1 hypothetical protein -
  C7K40_RS08950 (C7K40_08945) - 1781430..1781735 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  C7K40_RS08955 (C7K40_08950) ruvX 1781747..1782166 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  C7K40_RS08960 (C7K40_08955) - 1782163..1782432 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  C7K40_RS08970 (C7K40_08965) - 1782604..1783737 (-) 1134 WP_032462983.1 ISAs1-like element IS1548 family transposase -
  C7K40_RS08975 (C7K40_08970) spx 1783870..1784268 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  C7K40_RS08980 (C7K40_08975) recA 1784559..1785695 (-) 1137 WP_023612663.1 recombinase RecA Machinery gene
  C7K40_RS08985 (C7K40_08980) cinA 1785784..1787055 (-) 1272 WP_023612670.1 competence/damage-inducible protein A Machinery gene
  C7K40_RS08990 (C7K40_08985) - 1787124..1787684 (-) 561 WP_023612646.1 DNA-3-methyladenine glycosylase I -
  C7K40_RS08995 (C7K40_08990) ruvA 1787694..1788290 (-) 597 WP_002982180.1 Holliday junction branch migration protein RuvA -
  C7K40_RS09000 (C7K40_08995) - 1788292..1789512 (-) 1221 WP_002992187.1 MFS transporter -
  C7K40_RS09005 (C7K40_09000) mutL 1789523..1791505 (-) 1983 WP_023612647.1 DNA mismatch repair endonuclease MutL -
  C7K40_RS09010 (C7K40_09005) - 1791600..1792751 (-) 1152 WP_023612650.1 site-specific integrase -
  C7K40_RS09770 (C7K40_09010) - 1793073..1793216 (+) 144 WP_011185066.1 putative holin-like toxin -
  C7K40_RS09750 - 1794117..1794626 (-) 510 WP_003049854.1 helix-turn-helix domain-containing protein -
  C7K40_RS09025 (C7K40_09020) - 1794838..1795026 (+) 189 WP_003049853.1 helix-turn-helix domain-containing protein -
  C7K40_RS09030 (C7K40_09025) - 1795042..1795650 (+) 609 WP_014407937.1 phage repressor protein -
  C7K40_RS09035 (C7K40_09030) - 1795671..1796078 (+) 408 WP_002992501.1 hypothetical protein -
  C7K40_RS09040 (C7K40_09035) - 1796092..1796721 (+) 630 WP_023612654.1 Rha family transcriptional regulator -
  C7K40_RS09045 (C7K40_09040) - 1796966..1797298 (+) 333 WP_011285276.1 hypothetical protein -
  C7K40_RS09535 - 1797295..1797435 (+) 141 WP_014612652.1 hypothetical protein -
  C7K40_RS09050 (C7K40_09045) - 1797416..1797613 (+) 198 WP_022555260.1 hypothetical protein -
  C7K40_RS09055 (C7K40_09050) - 1797626..1797988 (+) 363 WP_000206026.1 hypothetical protein -
  C7K40_RS09060 (C7K40_09055) - 1797985..1798314 (+) 330 WP_000174505.1 hypothetical protein -
  C7K40_RS09065 (C7K40_09060) - 1798317..1798589 (+) 273 WP_014407941.1 hypothetical protein -
  C7K40_RS09070 (C7K40_09065) - 1798582..1799448 (+) 867 WP_032466280.1 primase alpha helix C-terminal domain-containing protein -
  C7K40_RS09075 (C7K40_09070) - 1799417..1801105 (+) 1689 WP_023612662.1 phage/plasmid primase, P4 family -
  C7K40_RS09080 (C7K40_09075) - 1801383..1801556 (+) 174 WP_000694577.1 hypothetical protein -
  C7K40_RS09540 - 1801562..1801735 (+) 174 WP_014635784.1 hypothetical protein -
  C7K40_RS09085 (C7K40_09080) - 1801737..1802246 (+) 510 WP_023612645.1 hypothetical protein -
  C7K40_RS09090 (C7K40_09085) - 1802321..1802809 (+) 489 WP_023612640.1 hypothetical protein -
  C7K40_RS09100 (C7K40_09095) - 1803212..1803574 (+) 363 WP_003058730.1 DUF1492 domain-containing protein -
  C7K40_RS09105 (C7K40_09100) - 1803549..1803932 (+) 384 WP_023612665.1 ArpU family phage packaging/lysis transcriptional regulator -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 46101.93 Da        Isoelectric Point: 4.9081

>NTDB_id=280471 C7K40_RS08985 WP_023612670.1 1785784..1787055(-) (cinA) [Streptococcus pyogenes strain DMG1800716]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRRDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPI
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYMAEKMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=280471 C7K40_RS08985 WP_023612670.1 1785784..1787055(-) (cinA) [Streptococcus pyogenes strain DMG1800716]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGGAGTGATTTGGTCATTTTATGCGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAGAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGATCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATTACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATA
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATATGGCCGAGAAGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Competence-damaged protein (CinA)

(263-416)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.74

100

0.697
  cinA Streptococcus mitis SK321

69.544

98.582

0.686
  cinA Streptococcus mitis NCTC 12261

69.065

98.582

0.681
  cinA Streptococcus pneumoniae TIGR4

68.106

98.582

0.671
  cinA Streptococcus pneumoniae Rx1

68.106

98.582

0.671
  cinA Streptococcus pneumoniae R6

68.106

98.582

0.671
  cinA Streptococcus pneumoniae D39

67.866

98.582

0.669
  cinA Streptococcus suis isolate S10

53.125

98.345

0.522
  cinA Bacillus subtilis subsp. subtilis str. 168

46.651

98.818

0.461

Multiple sequence alignment