Detailed information NTG0271478

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: C4N11_RS11845
• Genome accession: NZ_CP026670
• Coordinates: 2216127..2216879 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain endophthalmitis isolate 335
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2211127..2221879

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C4N11_RS12740	-	2213561..2215163 (-)	1603	Protein_2189	YhgE/Pip family protein	-
C4N11_RS11830 (C4N11_11830)	-	2215342..2215884 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
C4N11_RS11845 (C4N11_11845)	comE	2216127..2216879 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
C4N11_RS11850 (C4N11_11850)	comD/comD2	2216876..2218201 (-)	1326	WP_000364843.1	competence system sensor histidine kinase ComD	Regulator
C4N11_RS11855 (C4N11_11855)	comC/comC2	2218222..2218347 (-)	126	WP_000799694.1	competence-stimulating peptide ComC	Regulator
C4N11_RS11865 (C4N11_11865)	rlmH	2218629..2219108 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
C4N11_RS11870 (C4N11_11870)	htrA	2219291..2220472 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
C4N11_RS11875 (C4N11_11875)	spo0J	2220530..2221288 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=271478 C4N11_RS11845 WP_000866065.1 2216127..2216879(-) (comE) [Streptococcus pneumoniae strain endophthalmitis isolate 335]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=271478 C4N11_RS11845 WP_000866065.1 2216127..2216879(-) (comE) [Streptococcus pneumoniae strain endophthalmitis isolate 335]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATTGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408