Detailed information    

insolico Bioinformatically predicted

Overview


Name   comC/comC2   Type   Regulator
Locus tag   C4N11_RS11855 Genome accession   NZ_CP026670
Coordinates   2218222..2218347 (-) Length   41 a.a.
NCBI ID   WP_000799694.1    Uniprot ID   Q9WW44
Organism   Streptococcus pneumoniae strain endophthalmitis isolate 335     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context


Location: 2213222..2223347
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C4N11_RS12740 - 2213561..2215163 (-) 1603 Protein_2189 YhgE/Pip family protein -
  C4N11_RS11830 (C4N11_11830) - 2215342..2215884 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  C4N11_RS11845 (C4N11_11845) comE 2216127..2216879 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  C4N11_RS11850 (C4N11_11850) comD/comD2 2216876..2218201 (-) 1326 WP_000364843.1 competence system sensor histidine kinase ComD Regulator
  C4N11_RS11855 (C4N11_11855) comC/comC2 2218222..2218347 (-) 126 WP_000799694.1 competence-stimulating peptide ComC Regulator
  C4N11_RS11865 (C4N11_11865) rlmH 2218629..2219108 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  C4N11_RS11870 (C4N11_11870) htrA 2219291..2220472 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  C4N11_RS11875 (C4N11_11875) spo0J 2220530..2221288 (+) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence


Protein


Download         Length: 41 a.a.        Molecular weight: 4892.93 Da        Isoelectric Point: 10.9061

>NTDB_id=271480 C4N11_RS11855 WP_000799694.1 2218222..2218347(-) (comC/comC2) [Streptococcus pneumoniae strain endophthalmitis isolate 335]
MKNTVKLEQFVALKEKDLQNIKGGEMRISRIILDFLFLRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=271480 C4N11_RS11855 WP_000799694.1 2218222..2218347(-) (comC/comC2) [Streptococcus pneumoniae strain endophthalmitis isolate 335]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAATATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains


Predicted by InterproScan.

(1-29)


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB Q9WW44

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC2 Streptococcus pneumoniae A66

97.561

100

0.976

  comC/comC2 Streptococcus pneumoniae TIGR4

97.561

100

0.976

  comC/comC1 Streptococcus pneumoniae R6

78.049

100

0.78

  comC/comC1 Streptococcus pneumoniae G54

78.049

100

0.78

  comC/comC1 Streptococcus pneumoniae D39

78.049

100

0.78

  comC/comC1 Streptococcus pneumoniae Rx1

78.049

100

0.78

  comC Streptococcus mitis SK321

75.61

100

0.756

  comC Streptococcus mitis NCTC 12261

60

97.561

0.585


Multiple sequence alignment