Detailed information NTG0026447

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SPYM_RS01125
• Genome accession: NC_009332
• Coordinates: 206377..207117 (+)
• Length: 246 a.a.
• NCBI ID: WP_002986100.1
• Uniprot ID: A0A0H2UT50
• Organism: Streptococcus pyogenes str. Manfredo
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 201377..212117

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPYM_RS01110 (SpyM50182)	gltX	201908..203353 (+)	1446	WP_002986105.1	glutamate--tRNA ligase	-
SPYM_RS01115 (SpyM50183)	-	203748..205094 (+)	1347	WP_002991186.1	sensor histidine kinase	-
SPYM_RS01120 (SpyM50184)	-	205091..206373 (+)	1283	Protein_177	GHKL domain-containing protein	-
SPYM_RS01125 (SpyM50186)	comE/blpR	206377..207117 (+)	741	WP_002986100.1	response regulator transcription factor	Regulator
SPYM_RS01130 (SpyM50187)	rnpA	207657..208016 (+)	360	WP_011888579.1	ribonuclease P protein component	-
SPYM_RS01135 (SpyM50188)	-	207982..208809 (+)	828	WP_002991181.1	YidC/Oxa1 family membrane protein insertase	-
SPYM_RS01140 (SpyM50189)	jag	208821..209735 (+)	915	WP_011888580.1	RNA-binding cell elongation regulator Jag/EloR	-
SPYM_RS01145 (SpyM50190)	rpmH	210050..210184 (+)	135	WP_002885866.1	50S ribosomal protein L34	-
SPYM_RS01150 (SpyM50191)	-	210458..211162 (+)	705	WP_011888581.1	N-acetylmannosamine-6-phosphate 2-epimerase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28881.47 Da
• Isoelectric Point: 6.4841

>NTDB_id=26447 SPYM_RS01125 WP_002986100.1 206377..207117(+) (comE/blpR) [Streptococcus pyogenes str. Manfredo]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=26447 SPYM_RS01125 WP_002986100.1 206377..207117(+) (comE/blpR) [Streptococcus pyogenes str. Manfredo]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCTGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCTTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCAGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGCAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGATTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCTCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

3D structure

• AlphaFold DB: A0A0H2UT50

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.903	100	0.382
comE/comE2	Streptococcus gordonii strain NCTC7865	37.903	100	0.382
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37