Detailed information NTG0259483

Bioinformatically predicted

Overview

• Name: cinA
• Type: Machinery gene
• Locus tag: CXP32_RS09875
• Genome accession: NZ_CP025256
• Coordinates: 1852342..1853598 (-)
• Length: 418 a.a.
• NCBI ID: WP_000642718.1
• Uniprot ID: P54184
• Organism: Streptococcus pneumoniae strain Xen35
• Function: facilitate localization of RecA (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1846996..1867431	1852342..1853598	within	0

Gene organization within MGE regions

Location: 1846996..1867431

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CXP32_RS09840 (CXP32_09840)	-	1846996..1847355 (-)	360	WP_084865738.1	hypothetical protein	-
CXP32_RS09845 (CXP32_09845)	-	1847401..1847607 (-)	207	WP_000366093.1	hypothetical protein	-
CXP32_RS09850 (CXP32_09850)	-	1847594..1847755 (-)	162	WP_000289348.1	helix-turn-helix transcriptional regulator	-
CXP32_RS09855 (CXP32_09855)	lytA	1848113..1849069 (-)	957	WP_000405234.1	N-acetylmuramoyl-L-alanine amidase LytA	-
CXP32_RS09860 (CXP32_09860)	-	1849445..1850815 (-)	1371	WP_001036271.1	MATE family efflux transporter	-
CXP32_RS09870 (CXP32_09870)	recA	1851121..1852287 (-)	1167	WP_001085462.1	recombinase RecA	Machinery gene
CXP32_RS09875 (CXP32_09875)	cinA	1852342..1853598 (-)	1257	WP_000642718.1	competence/damage-inducible protein A	Machinery gene
CXP32_RS09880 (CXP32_09880)	-	1853683..1854699 (-)	1017	WP_000239283.1	LCP family protein	-
CXP32_RS09885 (CXP32_09885)	-	1854707..1855225 (-)	519	WP_000455537.1	GNAT family N-acetyltransferase	-
CXP32_RS09890 (CXP32_09890)	tsaE	1855215..1855658 (-)	444	WP_000288232.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE	-
CXP32_RS09895 (CXP32_09895)	comM	1855744..1856364 (-)	621	WP_000839908.1	hypothetical protein	Regulator
CXP32_RS09905 (CXP32_09905)	-	1856747..1857610 (-)	864	WP_001093641.1	helix-turn-helix transcriptional regulator	-
CXP32_RS12630 (CXP32_09910)	-	1857802..1857972 (+)	171	WP_001227862.1	PhrA family quorum-sensing system peptide	-
CXP32_RS09915 (CXP32_09915)	pneA1	1858075..1858299 (+)	225	WP_000181087.1	two-peptide bacteriocin subunit PneA1	-
CXP32_RS09920 (CXP32_09920)	pneA2	1858306..1858494 (+)	189	WP_000786759.1	two-peptide bacteriocin subunit PneA2	-
CXP32_RS09925 (CXP32_09925)	lanM	1858610..1861600 (+)	2991	WP_000875573.1	type 2 lanthipeptide synthetase LanM	-
CXP32_RS09930 (CXP32_09930)	-	1861950..1862654 (+)	705	WP_001033170.1	flavodoxin family protein	-
CXP32_RS09935 (CXP32_09935)	-	1862635..1863564 (+)	930	WP_000912954.1	M50 family metallopeptidase	-
CXP32_RS09940 (CXP32_09940)	-	1863561..1865669 (+)	2109	WP_000701298.1	peptidase domain-containing ABC transporter	-
CXP32_RS09945 (CXP32_09945)	-	1865693..1867105 (+)	1413	WP_000699968.1	S8 family serine peptidase	-
CXP32_RS12460	-	1867159..1867431 (+)	273	WP_000939671.1	hypothetical protein	-

Sequence

Protein

• Length: 418 a.a.
• Molecular weight: 45091.48 Da
• Isoelectric Point: 4.6027

>NTDB_id=259483 CXP32_RS09875 WP_000642718.1 1852342..1853598(-) (cinA) [Streptococcus pneumoniae strain Xen35]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFTLRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFKGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide

• Length: 1257 bp

>NTDB_id=259483 CXP32_RS09875 WP_000642718.1 1852342..1853598(-) (cinA) [Streptococcus pneumoniae strain Xen35]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGGCAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTACCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTAAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

• Competence-damaged protein (CinA) (262-414)

• Damage-inducible protein CinA KH domain (CinA_KH) (177-240)

• Probable molybdopterin binding domain (MoCF_biosynth) (5-169)

3D structure

• AlphaFold DB: P54184

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cinA	Streptococcus pneumoniae TIGR4	100	100	1
cinA	Streptococcus pneumoniae Rx1	99.282	100	0.993
cinA	Streptococcus pneumoniae R6	99.282	100	0.993
cinA	Streptococcus pneumoniae D39	99.043	100	0.99
cinA	Streptococcus mitis SK321	93.541	100	0.935
cinA	Streptococcus mitis NCTC 12261	93.301	100	0.933
cinA	Streptococcus mutans UA159	70.813	100	0.708
cinA	Streptococcus suis isolate S10	54.808	99.522	0.545
cinA	Bacillus subtilis subsp. subtilis str. 168	45.455	100	0.455