Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   CO687_RS03055 Genome accession   NZ_CP023511
Coordinates   639302..640495 (-) Length   397 a.a.
NCBI ID   WP_008808035.1    Uniprot ID   A0AB35FPK4
Organism   Streptococcus gordonii strain FDAARGOS_371     
Function   repress competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 641454..664393 639302..640495 flank 959


Gene organization within MGE regions


Location: 639302..664393
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CO687_RS03055 (CO687_03055) htrA 639302..640495 (-) 1194 WP_008808035.1 S1C family serine protease Regulator
  CO687_RS03060 (CO687_03060) rlmH 640689..641168 (+) 480 WP_008808034.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  CO687_RS03070 (CO687_03070) comC/comC1 641454..641618 (+) 165 WP_080998577.1 bacteriocin Regulator
  CO687_RS03075 (CO687_03075) comD/comD2 641631..642992 (+) 1362 WP_301335837.1 competence system sensor histidine kinase ComD Regulator
  CO687_RS03080 (CO687_03080) comE/comE2 642989..643756 (+) 768 WP_008808031.1 competence system response regulator transcription factor ComE Regulator
  CO687_RS03095 (CO687_03095) ychF 644078..645193 (+) 1116 WP_008808030.1 redox-regulated ATPase YchF -
  CO687_RS03100 (CO687_03100) pth 645267..645836 (+) 570 WP_096754921.1 aminoacyl-tRNA hydrolase -
  CO687_RS03105 (CO687_03105) mfd 645829..649332 (+) 3504 WP_096754922.1 transcription-repair coupling factor -
  CO687_RS03110 (CO687_03110) - 649398..649664 (+) 267 WP_012131074.1 RNA-binding S4 domain-containing protein -
  CO687_RS03115 (CO687_03115) - 649657..650025 (+) 369 WP_060970645.1 septum formation initiator family protein -
  CO687_RS03120 (CO687_03120) - 650028..650147 (+) 120 WP_037622626.1 SP_0009 family protein -
  CO687_RS03125 (CO687_03125) - 650147..651427 (+) 1281 WP_045772579.1 serine hydrolase -
  CO687_RS03130 (CO687_03130) tilS 651424..652701 (+) 1278 WP_008808024.1 tRNA lysidine(34) synthetase TilS -
  CO687_RS03135 (CO687_03135) hpt 652706..653248 (+) 543 WP_060970644.1 hypoxanthine phosphoribosyltransferase -
  CO687_RS03140 (CO687_03140) ftsH 653267..655249 (+) 1983 WP_046164766.1 ATP-dependent zinc metalloprotease FtsH -
  CO687_RS03155 (CO687_03155) comR/comR2 655778..656260 (+) 483 WP_048778891.1 sigma-70 family RNA polymerase sigma factor Regulator
  CO687_RS03265 (CO687_03265) mreC 663076..663891 (+) 816 WP_061596025.1 rod shape-determining protein MreC -
  CO687_RS03270 (CO687_03270) mreD 663893..664393 (+) 501 WP_061602340.1 rod shape-determining protein MreD -

Sequence

Protein


Download         Length: 397 a.a.        Molecular weight: 42225.90 Da        Isoelectric Point: 5.4898

>NTDB_id=247941 CO687_RS03055 WP_008808035.1 639302..640495(-) (htrA) [Streptococcus gordonii strain FDAARGOS_371]
MKNSSNFFKKTLQIFIVLLVGFIGGVAGTWGFSYFSTPHSATNNNQKTATTVTTSYKNSNSTTKAVDKVKDAVVSVITYS
ESNSDTIFDNNNSGNENDQVASEGSGVIYRKDKDYAYLVTNTHVINGAKKVDIRLADGNKVPGEIVGTDTYSDISVVRIP
ADKVKNVAEFGDSSKLTVGETAIAIGSPLGSDYANTVTQGIVSSLSRNVSSRSEDGQTIATQAIQTDAAINPGNSGGPLV
NIQGQVIGITSSKIANTNNGSTSVEGMGFAIPSNDVVNIIEQLEKNGKVIRPALGIQMVNLSSLSSSSSDRLKLPDNVKN
GVVVRSTQTGMPADGKLQKYDVITKIDDTEISSASDIQSALYKHSINEEIKVTYYRDGKEQTTTIKLTKSTDDLSSE

Nucleotide


Download         Length: 1194 bp        

>NTDB_id=247941 CO687_RS03055 WP_008808035.1 639302..640495(-) (htrA) [Streptococcus gordonii strain FDAARGOS_371]
ATGAAAAACTCTTCAAATTTCTTCAAAAAAACATTGCAAATTTTCATTGTTTTGTTAGTTGGTTTTATAGGTGGTGTTGC
TGGAACATGGGGATTTTCTTATTTTTCAACACCTCATTCAGCCACAAATAATAATCAGAAAACAGCGACTACAGTAACAA
CATCCTATAAAAATAGTAATTCTACAACAAAGGCTGTTGATAAAGTAAAAGATGCTGTTGTCTCTGTCATTACATATTCT
GAATCTAATTCGGATACTATTTTTGACAACAATAATTCAGGAAATGAAAATGATCAGGTAGCTAGCGAAGGATCTGGTGT
TATCTATAGAAAAGATAAAGACTATGCTTACTTAGTTACCAATACACACGTTATCAATGGTGCAAAAAAAGTTGATATCC
GTCTTGCTGATGGGAATAAGGTTCCTGGTGAAATAGTCGGGACTGATACATATTCTGATATTTCTGTAGTCAGAATTCCT
GCCGATAAGGTTAAAAATGTAGCAGAATTTGGAGATTCTAGTAAATTAACCGTTGGAGAAACTGCCATTGCAATCGGAAG
TCCTCTTGGTTCTGATTATGCTAATACAGTAACTCAGGGAATTGTTTCTAGTCTAAGCCGTAATGTTTCTTCACGATCAG
AAGATGGTCAGACAATTGCTACCCAAGCTATTCAAACTGATGCAGCAATTAATCCAGGTAACTCTGGTGGTCCTCTTGTA
AACATTCAAGGTCAAGTTATTGGTATTACCTCTAGTAAAATTGCTAACACCAATAATGGTAGTACTTCTGTTGAAGGTAT
GGGATTTGCAATCCCATCCAATGATGTTGTAAATATCATTGAACAATTAGAAAAGAATGGTAAAGTCATTCGACCAGCTC
TAGGAATTCAAATGGTCAACTTAAGTAGTTTGTCTTCTTCAAGCTCTGATCGATTAAAACTTCCAGACAATGTTAAAAAT
GGTGTCGTTGTTCGTTCCACACAAACTGGAATGCCTGCTGATGGTAAGTTACAAAAATATGATGTGATTACAAAAATTGA
TGATACAGAAATATCATCTGCTAGCGATATCCAATCAGCTCTTTATAAACATTCAATTAATGAAGAAATTAAAGTTACTT
ATTATCGTGATGGAAAAGAGCAAACAACAACTATTAAACTAACTAAATCAACTGATGATTTAAGTTCTGAATAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(236-391)

PDZ domain (PDZ_2)

(292-387)

Trypsin-like peptidase domain (Trypsin_2)

(104-249)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

98.992

100

0.99
  htrA Streptococcus mitis NCTC 12261

66.08

100

0.662
  htrA Streptococcus pneumoniae Rx1

66.162

99.748

0.66
  htrA Streptococcus pneumoniae D39

66.162

99.748

0.66
  htrA Streptococcus pneumoniae R6

66.162

99.748

0.66
  htrA Streptococcus pneumoniae TIGR4

66.162

99.748

0.66
  htrA Streptococcus mutans UA159

56.391

100

0.567

Multiple sequence alignment