Detailed information NTG0022546

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SPYM18_RS01130
• Genome accession: NC_003485
• Coordinates: 205666..206406 (+)
• Length: 246 a.a.
• NCBI ID: WP_011017314.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes MGAS8232
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 200666..211406

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPYM18_RS01115 (spyM18_0223)	gltX	201197..202642 (+)	1446	WP_002986105.1	glutamate--tRNA ligase	-
SPYM18_RS01120 (spyM18_0224)	-	203036..204382 (+)	1347	WP_011017312.1	sensor histidine kinase	-
SPYM18_RS01125 (spyM18_0226)	-	204379..205662 (+)	1284	WP_011017313.1	sensor histidine kinase	-
SPYM18_RS01130 (spyM18_0227)	comE/blpR	205666..206406 (+)	741	WP_011017314.1	response regulator transcription factor	Regulator
SPYM18_RS01135 (spyM18_0228)	rnpA	206946..207305 (+)	360	WP_002992035.1	ribonuclease P protein component	-
SPYM18_RS01140 (spyM18_0229)	-	207271..208098 (+)	828	WP_002991181.1	YidC/Oxa1 family membrane protein insertase	-
SPYM18_RS01145 (spyM18_0230)	jag	208110..209024 (+)	915	WP_011017315.1	RNA-binding cell elongation regulator Jag/EloR	-
SPYM18_RS01150 (spyM18_0232)	rpmH	209339..209473 (+)	135	WP_002885866.1	50S ribosomal protein L34	-
SPYM18_RS01155 (spyM18_0233)	-	209747..210451 (+)	705	WP_010921873.1	N-acetylmannosamine-6-phosphate 2-epimerase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28909.53 Da
• Isoelectric Point: 6.4841

>NTDB_id=22546 SPYM18_RS01130 WP_011017314.1 205666..206406(+) (comE/blpR) [Streptococcus pyogenes MGAS8232]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFVPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=22546 SPYM18_RS01130 WP_011017314.1 205666..206406(+) (comE/blpR) [Streptococcus pyogenes MGAS8232]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGTTCCTATTTCTTTTAAATATAAGGTATCTGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCTTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCAGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGCAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGATTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCTCTTCGCTAA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-242)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.115	99.187	0.378
comE	Streptococcus pneumoniae D39	38.115	99.187	0.378
comE	Streptococcus pneumoniae R6	38.115	99.187	0.378
comE	Streptococcus pneumoniae TIGR4	38.115	99.187	0.378
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.5	100	0.378
comE/comE2	Streptococcus gordonii strain NCTC7865	37.5	100	0.378
comE	Streptococcus mitis NCTC 12261	37.344	97.967	0.366
comE	Streptococcus mitis SK321	37.344	97.967	0.366