Detailed information NTG0210858

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: BUM80_RS08760
• Genome accession: NZ_CP018838
• Coordinates: 1611457..1612209 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 11A
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1606457..1617209

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BUM80_RS08740 (BUM80_08955)	-	1607902..1610544 (-)	2643	WP_100910940.1	YhgE/Pip domain-containing protein	-
BUM80_RS08745 (BUM80_08960)	-	1610672..1611214 (+)	543	WP_049511269.1	TetR/AcrR family transcriptional regulator	-
BUM80_RS08760 (BUM80_08975)	comE	1611457..1612209 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
BUM80_RS08765 (BUM80_08980)	comD/comD1	1612206..1613531 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
BUM80_RS08770 (BUM80_08985)	comC/comC1	1613552..1613677 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
BUM80_RS08780 (BUM80_08995)	rlmH	1613959..1614438 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
BUM80_RS08785 (BUM80_09000)	htrA	1614621..1615802 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
BUM80_RS08790 (BUM80_09005)	spo0J	1615860..1616618 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=210858 BUM80_RS08760 WP_000866065.1 1611457..1612209(-) (comE) [Streptococcus pneumoniae strain 11A]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=210858 BUM80_RS08760 WP_000866065.1 1611457..1612209(-) (comE) [Streptococcus pneumoniae strain 11A]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAAGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408