Detailed information NTG0020329

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: SMA_0105
• Genome accession: HE613569
• Coordinates: 109391..110290 (+)
• Length: 299 a.a.
• NCBI ID: CCF01396.1
• Uniprot ID: -
• Organism: Streptococcus macedonicus ACA-DC 198
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 104391..115290

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMA_0097	comYF	104485..104952 (+)	468	CCF01388.1	Late competence protein ComGF, access of DNA to ComEA	Machinery gene
SMA_0098	comYG	104924..105229 (+)	306	CCF01389.1	Late competence protein ComGG	Machinery gene
SMA_0099	comYH	105311..106267 (+)	957	CCF01390.1	Adenine-specific methyltransferase	Machinery gene
SMA_0100	ackA	106320..107519 (+)	1200	CCF01391.1	Acetate kinase	-
SMA_0101	-	107681..107881 (+)	201	CCF01392.1	Transcriptional regulator, Cro/CI family	-
SMA_0102	-	107891..108100 (+)	210	CCF01393.1	Hypothetical protein	-
SMA_0103	-	108113..108565 (+)	453	CCF01394.1	Hypothetical protein	-
SMA_0104	-	108577..109212 (+)	636	CCF01395.1	Membrane-bound protease, CAAX family	-
SMA_0105	comR	109391..110290 (+)	900	CCF01396.1	Transcriptional regulator	Regulator
-	comS	110367..110411 (+)	45	-	-	Regulator
SMA_0106	purD	110764..112026 (+)	1263	CCF01397.1	Phosphoribosylamine--glycine ligase	-
SMA_0107	ybbK	112016..112465 (+)	450	CCF01398.1	Hypothetical protein	-
SMA_0108	purE	112465..112953 (+)	489	CCF01399.1	Phosphoribosylaminoimidazole carboxylase catalytic subunit	-
SMA_0109	purK	112940..114031 (+)	1092	CCF01400.1	Phosphoribosylaminoimidazole carboxylase ATPase subunit	-
SMA_0110	-	114051..114329 (+)	279	CCF01401.1	Hypothetical protein	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 34976.10 Da
• Isoelectric Point: 4.9629

>NTDB_id=20329 SMA_0105 CCF01396.1 109391..110290(+) (comR) [Streptococcus macedonicus ACA-DC 198]
MEKFGIKVRALREEKGISREEFCGDETELSVRQLARIEKGQSVPTLNKVGYIAKVLDVTIGELVDGKNLELPTRYKELKY
LLLRTPTYGDEKRLQRQTSYFDEIAERYYEVIPEEERLVIDCLQSKIDVHFSDDVNFGEGILNDYFDQVRRKKKFQINDL
ILIDLYFACLASAKSFEGIYSLDLYDELMECLLNQENLSPETSLILNNVLLNNVDLVLRFHRESFIKRIIIKSDTIMASV
HDFQRRPVLSLVEWKYYLQFKKDFLAAQKSYSNAILFANLIGDTYLKSKLVEEWNNDTT

Nucleotide

• Length: 900 bp

>NTDB_id=20329 SMA_0105 CCF01396.1 109391..110290(+) (comR) [Streptococcus macedonicus ACA-DC 198]
TTGGAAAAGTTTGGGATTAAAGTACGTGCATTAAGAGAGGAAAAAGGAATTTCACGTGAGGAATTTTGTGGCGATGAAAC
AGAATTGTCTGTACGGCAATTAGCTAGAATTGAAAAGGGACAATCCGTTCCAACTCTTAATAAAGTGGGATATATTGCAA
AGGTTTTGGACGTAACGATTGGTGAATTAGTTGATGGTAAAAATCTAGAGCTTCCTACTAGATACAAGGAGTTAAAGTAT
TTATTATTGCGAACACCGACTTATGGAGATGAGAAACGTCTTCAGAGACAAACTTCCTATTTTGACGAGATTGCAGAAAG
ATATTACGAAGTTATACCTGAAGAGGAACGTTTGGTTATTGATTGTTTACAATCAAAGATTGATGTTCATTTCAGTGATG
ATGTTAATTTTGGTGAGGGAATTTTAAATGACTATTTTGACCAGGTTAGACGAAAGAAAAAATTTCAAATCAATGATTTG
ATTTTAATAGATTTATATTTTGCTTGCCTTGCTTCTGCTAAATCGTTTGAGGGAATCTATAGCTTAGATTTATATGATGA
ATTAATGGAGTGTTTGCTGAATCAAGAAAATCTTTCGCCAGAAACTTCTTTGATTTTAAATAATGTTTTATTAAATAATG
TAGATTTGGTTTTACGATTCCATAGAGAATCATTTATAAAACGAATAATTATAAAAAGCGACACTATCATGGCAAGTGTT
CATGATTTTCAAAGACGTCCAGTTTTAAGTTTAGTTGAGTGGAAATATTATTTACAATTTAAAAAAGATTTTTTAGCGGC
ACAAAAATCTTACTCCAATGCAATTTTATTTGCTAATTTAATTGGAGATACTTATTTGAAAAGTAAATTAGTAGAAGAAT
GGAATAATGATACAACATGA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (8-63)

• ComR tetratricopeptide (ComR_TPR) (72-294)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	71.777	95.987	0.689
comR	Streptococcus mutans UA159	53.512	100	0.535
comR	Streptococcus pyogenes MGAS8232	48.667	100	0.488
comR	Streptococcus pyogenes MGAS315	47.651	99.666	0.475
comR	Streptococcus suis P1/7	39.933	99.666	0.398
comR	Streptococcus suis 05ZYH33	40.067	99.331	0.398
comR	Streptococcus suis D9	38.591	99.666	0.385