Detailed information NTG0020235

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: Spy49_0206
• Genome accession: CP000829
• Coordinates: 215977..216717 (+)
• Length: 246 a.a.
• NCBI ID: ACI60548.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes NZ131
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 210977..221717

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Spy49_0203	gluS	211506..212996 (+)	1491	ACI60545.1	Glutamyl-tRNA synthetase	-
Spy49_0204	fasB	213347..214693 (+)	1347	ACI60546.1	Putative histidine kinase	-
Spy49_0205	-	214690..215973 (+)	1284	ACI60547.1	Putative histidine kinase	-
Spy49_0206	comE/blpR	215977..216717 (+)	741	ACI60548.1	Response regulator FasA	Regulator
Spy49_0207	rnpA	217257..217616 (+)	360	ACI60549.1	Ribonuclease P protein component	-
Spy49_0208	-	217600..218409 (+)	810	ACI60550.1	Membrane protein oxaA 1 precursor	-
Spy49_0209	-	218421..219335 (+)	915	ACI60551.1	R3H domain protein	-
Spy49_0210	rpmH	219650..219784 (+)	135	ACI60552.1	LSU ribosomal protein L34p	-
Spy49_0211	-	220058..220762 (+)	705	ACI60553.1	N-acetylmannosamine-6-phosphate 2-epimerase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28881.47 Da
• Isoelectric Point: 6.4841

>NTDB_id=20235 Spy49_0206 ACI60548.1 215977..216717(+) (comE/blpR) [Streptococcus pyogenes NZ131]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=20235 Spy49_0206 ACI60548.1 215977..216717(+) (comE/blpR) [Streptococcus pyogenes NZ131]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCCGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCAGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGCAGTGGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGATTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCTCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.903	100	0.382
comE/comE2	Streptococcus gordonii strain NCTC7865	37.903	100	0.382
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37