Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   A7J08_RS06320 Genome accession   NZ_CP017088
Coordinates   1265975..1266715 (-) Length   246 a.a.
NCBI ID   WP_014638212.1    Uniprot ID   G7SEA1
Organism   Streptococcus suis strain SRD478     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1263370..1284893 1265975..1266715 within 0


Gene organization within MGE regions


Location: 1263370..1284893
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A7J08_RS06310 - 1264292..1264453 (+) 162 WP_014638210.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  A7J08_RS06315 (A7J08_06145) - 1264621..1265964 (-) 1344 WP_105105954.1 GHKL domain-containing protein -
  A7J08_RS06320 (A7J08_06150) comE/blpR 1265975..1266715 (-) 741 WP_014638212.1 response regulator transcription factor Regulator
  A7J08_RS06325 (A7J08_06155) - 1266727..1267059 (-) 333 WP_014638213.1 LytTR family DNA-binding domain-containing protein -
  A7J08_RS10630 - 1267252..1267638 (+) 387 WP_014638214.1 hypothetical protein -
  A7J08_RS10635 - 1267580..1269165 (-) 1586 Protein_1179 SAG1250 family conjugative relaxase -
  A7J08_RS06345 (A7J08_06175) - 1269285..1269902 (-) 618 WP_014638217.1 SAP domain-containing protein -
  A7J08_RS06350 - 1269915..1270103 (-) 189 Protein_1181 hypothetical protein -
  A7J08_RS06355 (A7J08_06180) rlmD 1270176..1271534 (-) 1359 WP_148115786.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
  A7J08_RS06360 (A7J08_06185) - 1271601..1272923 (-) 1323 WP_053867319.1 LCP family protein -
  A7J08_RS06365 (A7J08_06190) pheA 1272935..1273762 (-) 828 WP_002941297.1 prephenate dehydratase -
  A7J08_RS06370 (A7J08_06195) - 1273753..1274244 (-) 492 WP_029176661.1 shikimate kinase -
  A7J08_RS06375 (A7J08_06200) aroA 1274253..1275533 (-) 1281 WP_053867318.1 3-phosphoshikimate 1-carboxyvinyltransferase -
  A7J08_RS06380 (A7J08_06205) - 1275749..1276738 (+) 990 WP_024399700.1 hypothetical protein -
  A7J08_RS06385 (A7J08_06210) - 1276783..1277745 (-) 963 WP_044761477.1 polyprenyl synthetase family protein -
  A7J08_RS06390 (A7J08_06215) - 1277841..1278737 (+) 897 WP_044759767.1 tyrosine-type recombinase/integrase -
  A7J08_RS06395 (A7J08_06220) - 1278769..1278954 (-) 186 WP_105124099.1 hypothetical protein -
  A7J08_RS06400 (A7J08_06225) - 1279358..1280554 (-) 1197 WP_148115787.1 NAD-dependent epimerase/dehydratase family protein -
  A7J08_RS06405 (A7J08_06230) wecB 1280566..1281741 (-) 1176 WP_148115788.1 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -
  A7J08_RS06410 (A7J08_06235) - 1281744..1282784 (-) 1041 WP_148115789.1 polysaccharide biosynthesis protein -
  A7J08_RS06415 (A7J08_06240) - 1282797..1284089 (-) 1293 WP_148115790.1 hypothetical protein -

Sequence

Protein


Download         Length: 246 a.a.        Molecular weight: 28874.95 Da        Isoelectric Point: 5.6240

>NTDB_id=195409 A7J08_RS06320 WP_014638212.1 1265975..1266715(-) (comE/blpR) [Streptococcus suis strain SRD478]
MNIFILEDDFFQQTRMENIVRQIVSDKQIGVKHFEVYGKPGQLLEDITERGGHQLFFLDIEIKDDKKKGLDLALEIRRKD
PHAEIVFVTTHSEFMPVSFQYHVSALDFIDKELSEKQFIERIEQSIDYVQNQQGQTLAEDSFIFKNAKTQVQIPFADLLY
IETSYIAHKLVLYSTRERIEFYGELSEIVKQEPRLFQCHRSYVVNPYNISSINRDERLVYLKNGSTCMVSRLKITALKEA
VENLHT

Nucleotide


Download         Length: 741 bp        

>NTDB_id=195409 A7J08_RS06320 WP_014638212.1 1265975..1266715(-) (comE/blpR) [Streptococcus suis strain SRD478]
ATGAATATCTTTATACTTGAAGATGATTTTTTTCAACAAACTCGAATGGAAAATATTGTTCGTCAAATAGTATCTGATAA
ACAAATTGGTGTCAAACATTTTGAAGTTTATGGAAAACCAGGTCAACTTTTAGAAGATATTACTGAAAGAGGAGGACATC
AACTTTTCTTTCTGGATATTGAAATCAAGGATGACAAGAAAAAAGGTTTAGATTTAGCTCTAGAGATTAGGCGAAAAGAT
CCTCATGCTGAAATTGTGTTTGTGACAACTCACTCAGAGTTTATGCCAGTTTCTTTCCAGTATCATGTTTCTGCTCTAGA
CTTTATTGATAAAGAATTATCGGAAAAACAGTTCATTGAGCGCATTGAACAATCAATTGACTATGTTCAAAATCAACAGG
GGCAAACTTTAGCTGAAGATTCATTTATTTTTAAAAACGCTAAGACTCAGGTTCAGATTCCATTTGCTGATTTACTTTAT
ATTGAAACATCATACATTGCCCATAAGCTGGTTCTTTATTCTACTAGAGAAAGGATTGAATTTTATGGTGAGTTATCTGA
AATAGTTAAACAAGAACCAAGATTATTTCAATGTCATCGCTCGTATGTTGTAAATCCCTATAATATATCATCCATCAATC
GAGACGAACGATTGGTTTACCTAAAAAATGGTTCGACATGTATGGTATCAAGGTTAAAGATTACTGCACTCAAAGAAGCA
GTCGAAAACCTTCATACATAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-241)

Response regulator receiver domain (Response_reg)

(3-123)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB G7SEA1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

52.869

99.187

0.524
  comE/comE1 Streptococcus equinus JB1

40.928

96.341

0.394
  comE/comE2 Streptococcus equinus JB1

38.115

99.187

0.378
  comE/comE2 Streptococcus gordonii strain NCTC7865

37.805

100

0.378
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

37.805

100

0.378
  comE Streptococcus pneumoniae Rx1

36.437

100

0.366
  comE Streptococcus pneumoniae D39

36.437

100

0.366
  comE Streptococcus pneumoniae R6

36.437

100

0.366
  comE Streptococcus pneumoniae TIGR4

36.437

100

0.366
  comE Streptococcus mitis NCTC 12261

36.437

100

0.366
  comE Streptococcus mitis SK321

36.437

100

0.366

Multiple sequence alignment