Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   A6J72_RS05915 Genome accession   NZ_CP020433
Coordinates   1191187..1193133 (+) Length   648 a.a.
NCBI ID   WP_082311997.1    Uniprot ID   -
Organism   Streptococcus intermedius strain FDAARGOS_233     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1186187..1198133
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A6J72_RS05895 (A6J72_05905) argR 1186748..1187188 (+) 441 WP_003075336.1 arginine repressor -
  A6J72_RS05900 (A6J72_05910) hexA 1187351..1189909 (+) 2559 WP_082311996.1 DNA mismatch repair protein MutS Machinery gene
  A6J72_RS05905 (A6J72_05915) - 1190050..1190508 (-) 459 WP_009569658.1 DUF3021 domain-containing protein -
  A6J72_RS05910 (A6J72_05920) brsR 1190505..1190945 (-) 441 WP_041823295.1 LytTR family DNA-binding domain-containing protein Regulator
  A6J72_RS05915 (A6J72_05925) hexB 1191187..1193133 (+) 1947 WP_082311997.1 DNA mismatch repair endonuclease MutL Machinery gene
  A6J72_RS05920 (A6J72_05930) - 1193279..1193788 (-) 510 WP_082311998.1 RDD family protein -
  A6J72_RS05925 (A6J72_05935) - 1193772..1194278 (-) 507 WP_082311999.1 helix-turn-helix domain-containing protein -
  A6J72_RS05930 (A6J72_05940) ruvA 1194448..1195041 (+) 594 WP_082312000.1 Holliday junction branch migration protein RuvA Machinery gene
  A6J72_RS05935 (A6J72_05945) - 1195051..1195605 (+) 555 WP_082312001.1 DNA-3-methyladenine glycosylase I -
  A6J72_RS10035 (A6J72_05950) - 1195610..1195783 (+) 174 Protein_1144 CPBP family intramembrane glutamate endopeptidase -
  A6J72_RS05945 (A6J72_05955) cinA 1195920..1197188 (+) 1269 WP_009569648.1 competence/damage-inducible protein A Machinery gene

Sequence

Protein


Download         Length: 648 a.a.        Molecular weight: 73464.05 Da        Isoelectric Point: 5.1595

>NTDB_id=186427 A6J72_RS05915 WP_082311997.1 1191187..1193133(+) (hexB) [Streptococcus intermedius strain FDAARGOS_233]
MSKIIELPEKLANQIAAGEVIERPSSVVKELIENSIDAGATQIIVEIEEAGLKSIQVIDNGEGIEHEEVPLALRRHATSK
IKKQADLFRIRTLGFRGEALPSIASVSCLTIETATETDQYGTLLVARGGEIECVEPTSSIVGTKIKVENLFFNTPARLKY
MKSQQAELSHIVDVMNRLSLAHPEIAFTLINDGKKMTQTVGTGNLRQAIAGVYGLTTAKKMIEISASNLDFEVSGYISLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPIAVIAIQIDPYLADVNVHPTKQEVRISKERELMVLISQ
AIAASLKEYDLIPDALENLAKSTINRVSKPEQTSLPLKENRLYYDQGRTDFFVKPQVSEDRPSFEKTDQLAQQPVAPDMP
DSRTVSIKFAERQAPSYDQLDHPELDQASMERALEKLDREGISTFPELEYFGQMHGTYLFAQGNGGLYIIDQHAAQERVK
YEYYRDKIGDVDDSQQQLLVPYIFEFPTDDMLRLQQRMSLLEEVGIFLEEYGVNQFILREHPIWLKEEEIESGVYEMCDM
LLLTKEVSIKKYRAELAIMMSCKRSIKANHSLDDYSARDLIFQLSQCNNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHT
SLRELGKY

Nucleotide


Download         Length: 1947 bp        

>NTDB_id=186427 A6J72_RS05915 WP_082311997.1 1191187..1193133(+) (hexB) [Streptococcus intermedius strain FDAARGOS_233]
ATGTCAAAAATTATAGAATTACCAGAAAAACTTGCCAATCAGATTGCAGCAGGTGAGGTCATCGAGCGACCTAGCAGCGT
GGTTAAGGAGTTGATAGAAAACTCCATTGATGCTGGTGCCACTCAGATTATAGTTGAGATTGAAGAAGCAGGTCTCAAGA
GTATTCAAGTCATTGATAATGGCGAAGGAATTGAGCATGAGGAAGTTCCCTTAGCTTTGCGTCGGCATGCGACGAGTAAG
ATTAAGAAACAAGCCGACCTTTTTCGAATTCGGACGTTGGGTTTTCGCGGTGAGGCCCTTCCATCTATCGCTTCCGTTTC
ATGTTTGACGATTGAAACTGCAACAGAGACAGATCAATATGGTACTCTCTTGGTAGCCCGAGGTGGTGAAATTGAGTGTG
TAGAACCAACGAGCAGCATTGTCGGAACAAAAATCAAAGTCGAAAATCTCTTTTTCAATACACCTGCTCGCTTGAAATAT
ATGAAAAGTCAGCAAGCCGAATTATCTCATATTGTAGATGTGATGAATCGTTTAAGTTTAGCCCATCCGGAGATTGCTTT
TACTCTAATAAATGACGGTAAAAAAATGACACAAACAGTAGGAACAGGGAATCTACGCCAAGCGATTGCTGGTGTTTATG
GACTGACAACGGCAAAAAAAATGATTGAGATTTCAGCTTCTAATCTGGATTTTGAAGTATCAGGCTATATTAGCCTGCCA
GAACTAACACGAGCTAATCGTAATTATATCACGATTCTCATAAATGGTCGCTATATTAAGAATTTCTTGCTCAATCGAGC
TATCCTTGATGGCTATGGTAGTAAGCTCATGGTGGGGCGTTTTCCGATTGCAGTGATTGCTATTCAGATTGATCCTTACC
TTGCTGATGTCAATGTTCATCCCACTAAGCAAGAAGTACGGATCTCAAAAGAGCGAGAGCTTATGGTCTTGATTTCACAA
GCGATTGCTGCGAGTCTAAAAGAGTATGATTTGATTCCAGATGCTTTGGAGAATTTAGCCAAATCAACTATTAATCGAGT
AAGTAAGCCTGAACAGACTAGCCTACCACTAAAGGAGAACCGACTTTATTACGACCAAGGAAGAACCGATTTCTTTGTGA
AACCACAAGTGTCAGAAGATCGACCTTCTTTTGAGAAAACTGACCAATTAGCTCAACAACCCGTTGCTCCAGATATGCCT
GATTCCAGAACAGTCTCTATTAAATTTGCAGAAAGGCAGGCGCCTTCTTATGACCAACTGGATCATCCTGAGTTAGATCA
AGCTAGTATGGAGAGAGCTTTAGAGAAGCTAGATAGAGAAGGAATATCAACCTTTCCAGAGTTGGAATATTTCGGTCAAA
TGCATGGCACCTATCTCTTTGCACAAGGAAATGGTGGTCTTTACATTATTGACCAGCATGCGGCTCAAGAACGGGTCAAG
TATGAATATTATAGGGACAAAATAGGAGATGTAGATGACAGCCAGCAGCAGCTTTTGGTGCCTTATATTTTTGAATTTCC
GACAGACGATATGCTGCGACTTCAACAACGAATGTCTCTTTTGGAAGAAGTGGGTATTTTCCTAGAAGAATATGGAGTCA
ATCAATTTATTTTGCGTGAACATCCTATTTGGCTCAAAGAAGAGGAAATTGAGTCAGGTGTCTATGAAATGTGTGATATG
CTGCTTTTGACCAAGGAAGTCTCTATTAAGAAATATCGTGCAGAGCTAGCTATTATGATGAGCTGTAAACGTTCTATTAA
GGCCAATCATAGCTTAGATGACTACTCGGCACGTGATTTAATTTTCCAACTATCACAATGCAACAATCCTTATAACTGTC
CACATGGTCGACCAGTCTTGGTTAACTTTACCAAGTCGGATATGGAAAAAATGTTTCGCCGCATTCAGGAAAATCATACT
AGCCTACGGGAGTTGGGTAAGTATTAA

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(450-592)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-120)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

75.422

100

0.758

Multiple sequence alignment