Detailed information NTG0144040

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: AL510_RS04860
• Genome accession: NZ_CP014027
• Coordinates: 949015..949755 (+)
• Length: 246 a.a.
• NCBI ID: WP_002986100.1
• Uniprot ID: A0A0H2UT50
• Organism: Streptococcus pyogenes strain FDAARGOS_149
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 944015..954755

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AL510_RS04845 (AL510_04685)	gltX	944545..945990 (+)	1446	WP_002986105.1	glutamate--tRNA ligase	-
AL510_RS04850 (AL510_04690)	-	946385..947731 (+)	1347	WP_011285380.1	sensor histidine kinase	-
AL510_RS04855 (AL510_04695)	-	947728..949011 (+)	1284	WP_010921869.1	sensor histidine kinase	-
AL510_RS04860 (AL510_04700)	comE/blpR	949015..949755 (+)	741	WP_002986100.1	response regulator transcription factor	Regulator
AL510_RS04865 (AL510_04705)	rnpA	950295..950654 (+)	360	WP_002992035.1	ribonuclease P protein component	-
AL510_RS04870 (AL510_04710)	-	950620..951447 (+)	828	WP_010921871.1	YidC/Oxa1 family membrane protein insertase	-
AL510_RS04875 (AL510_04715)	jag	951459..952373 (+)	915	WP_010921872.1	RNA-binding cell elongation regulator Jag/EloR	-
AL510_RS04880 (AL510_04720)	rpmH	952688..952822 (+)	135	WP_002885866.1	50S ribosomal protein L34	-
AL510_RS04885 (AL510_04725)	-	953096..953800 (+)	705	WP_010921873.1	N-acetylmannosamine-6-phosphate 2-epimerase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28881.47 Da
• Isoelectric Point: 6.4841

>NTDB_id=144040 AL510_RS04860 WP_002986100.1 949015..949755(+) (comE/blpR) [Streptococcus pyogenes strain FDAARGOS_149]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=144040 AL510_RS04860 WP_002986100.1 949015..949755(+) (comE/blpR) [Streptococcus pyogenes strain FDAARGOS_149]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCCGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCAGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGCAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGATTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCTCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

3D structure

• AlphaFold DB: A0A0H2UT50

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.903	100	0.382
comE/comE2	Streptococcus gordonii strain NCTC7865	37.903	100	0.382
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37