Detailed information NTG0139725

Bioinformatically predicted

Overview

• Name: comGC
• Type: Machinery gene
• Locus tag: APQ13_RS08630
• Genome accession: NZ_CP013237
• Coordinates: 1789263..1789577 (+)
• Length: 104 a.a.
• NCBI ID: WP_002263437.1
• Uniprot ID: Q8DS51
• Organism: Streptococcus mutans strain NG8 isolate Dental Plaque
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1784263..1794577

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
APQ13_RS08615 (APQ13_08595)	-	1786842..1787225 (+)	384	WP_002264248.1	DUF1033 family protein	-
APQ13_RS08620 (APQ13_08600)	comGA	1787355..1788296 (+)	942	WP_002263435.1	competence type IV pilus ATPase ComGA	Machinery gene
APQ13_RS08625 (APQ13_08605)	comGB	1788232..1789263 (+)	1032	WP_255262721.1	competence type IV pilus assembly protein ComGB	Machinery gene
APQ13_RS08630 (APQ13_08610)	comGC	1789263..1789577 (+)	315	WP_002263437.1	competence type IV pilus major pilin ComGC	Machinery gene
APQ13_RS08635 (APQ13_08615)	comGD	1789564..1789968 (+)	405	WP_002264246.1	competence type IV pilus minor pilin ComGD	Machinery gene
APQ13_RS08640 (APQ13_08620)	comGE	1789940..1790233 (+)	294	WP_002263439.1	competence type IV pilus minor pilin ComGE	Machinery gene
APQ13_RS08645 (APQ13_08625)	comGF	1790220..1790654 (+)	435	WP_061046398.1	competence type IV pilus minor pilin ComGF	Machinery gene
APQ13_RS08650 (APQ13_08630)	comGG	1790632..1791021 (+)	390	WP_002263441.1	competence type IV pilus minor pilin ComGG	Machinery gene
APQ13_RS08655 (APQ13_08635)	comGH	1791076..1792029 (+)	954	WP_002263442.1	class I SAM-dependent methyltransferase	Machinery gene
APQ13_RS08660 (APQ13_08640)	-	1792088..1793287 (+)	1200	WP_002263443.1	acetate kinase	-
APQ13_RS08665 (APQ13_08645)	-	1793840..1794085 (+)	246	WP_002263444.1	helix-turn-helix transcriptional regulator	-
APQ13_RS08670 (APQ13_08650)	-	1794054..1794494 (+)	441	WP_002263445.1	hypothetical protein	-

Sequence

Protein

• Length: 104 a.a.
• Molecular weight: 11591.60 Da
• Isoelectric Point: 10.2206

>NTDB_id=139725 APQ13_RS08630 WP_002263437.1 1789263..1789577(+) (comGC) [Streptococcus mutans strain NG8 isolate Dental Plaque]
MKKIKRVSVRAFTLIEMLVVLLIISILLLLFVPNLTKQKDKVKDTGGSAVVKVVESQAELYELNKTDSATLSKLVASGDI
TQEQANSYKDYYAKHPSKTRHVAN

Nucleotide

• Length: 315 bp

>NTDB_id=139725 APQ13_RS08630 WP_002263437.1 1789263..1789577(+) (comGC) [Streptococcus mutans strain NG8 isolate Dental Plaque]
ATGAAAAAGATCAAGAGAGTCAGTGTACGAGCTTTTACGCTTATAGAAATGTTAGTAGTTCTTCTCATTATTAGTATTCT
TTTACTATTATTTGTTCCTAATTTAACTAAGCAAAAAGATAAGGTAAAAGATACTGGCGGTTCTGCCGTGGTTAAAGTTG
TAGAAAGTCAGGCTGAGCTTTATGAGCTTAATAAAACCGATTCTGCTACTCTTTCTAAATTAGTAGCTAGTGGTGATATT
ACACAAGAACAGGCAAATTCATACAAGGATTACTATGCAAAACACCCAAGTAAAACACGGCATGTCGCGAATTAA

Domains

Predicted by InterProScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (9-30)

3D structure

• AlphaFold DB: Q8DS51

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGC	Streptococcus mutans UA140	100	100	1
comGC	Streptococcus mutans UA159	100	100	1
comGC	Streptococcus gordonii str. Challis substr. CH1	71.429	100	0.721
comGC/cglC	Streptococcus mitis SK321	66.667	95.192	0.635
comGC/cglC	Streptococcus mitis NCTC 12261	69.565	88.462	0.615
comGC/cglC	Streptococcus pneumoniae R6	63.636	95.192	0.606
comGC/cglC	Streptococcus pneumoniae Rx1	63.636	95.192	0.606
comGC/cglC	Streptococcus pneumoniae D39	63.636	95.192	0.606
comGC/cglC	Streptococcus pneumoniae TIGR4	63.636	95.192	0.606
comGC	Lactococcus lactis subsp. cremoris KW2	55.446	97.115	0.538
comGC	Streptococcus suis isolate S10	60.227	84.615	0.51