Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   DK43_RS00670 Genome accession   NZ_CP007573
Coordinates   132544..133812 (+) Length   422 a.a.
NCBI ID   WP_022525214.1    Uniprot ID   A0AAI9J627
Organism   Streptococcus anginosus strain SA1     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 126673..166366 132544..133812 within 0


Gene organization within MGE regions


Location: 126673..166366
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DK43_RS00640 (DK43_00665) - 126673..127821 (+) 1149 WP_003027782.1 site-specific integrase -
  DK43_RS00645 (DK43_00670) mutL 127916..129862 (+) 1947 WP_037593386.1 DNA mismatch repair endonuclease MutL -
  DK43_RS00650 (DK43_00675) ruvA 129996..130586 (+) 591 WP_003027779.1 Holliday junction branch migration protein RuvA -
  DK43_RS00655 (DK43_00680) - 130596..131150 (+) 555 WP_003027778.1 DNA-3-methyladenine glycosylase I -
  DK43_RS00660 (DK43_00685) - 131155..131813 (+) 659 Protein_130 lysostaphin resistance A-like protein -
  DK43_RS00665 (DK43_00690) - 131864..132274 (-) 411 WP_003027775.1 helix-turn-helix transcriptional regulator -
  DK43_RS00670 (DK43_00700) cinA 132544..133812 (+) 1269 WP_022525214.1 competence/damage-inducible protein A Machinery gene
  DK43_RS00675 (DK43_00705) recA 133860..135005 (+) 1146 WP_003027772.1 recombinase RecA Machinery gene
  DK43_RS00680 (DK43_00710) spx 135092..135490 (+) 399 WP_003027770.1 transcriptional regulator Spx -
  DK43_RS00685 (DK43_00715) - 135574..136143 (+) 570 WP_003027769.1 SP0191 family lipoprotein -
  DK43_RS00690 (DK43_00720) - 136248..136805 (+) 558 WP_022525213.1 SP0191 family lipoprotein -
  DK43_RS00695 (DK43_00725) - 136928..137194 (+) 267 WP_009569646.1 IreB family regulatory phosphoprotein -
  DK43_RS00700 (DK43_00730) ruvX 137194..137613 (+) 420 WP_003027766.1 Holliday junction resolvase RuvX -
  DK43_RS00705 (DK43_00735) - 137631..137942 (+) 312 WP_003027765.1 DUF1292 domain-containing protein -
  DK43_RS00710 (DK43_00740) - 138143..139384 (+) 1242 WP_003027764.1 folylpolyglutamate synthase/dihydrofolate synthase family protein -
  DK43_RS00715 (DK43_00745) - 139433..139870 (+) 438 WP_003027763.1 SP_0198 family lipoprotein -
  DK43_RS00720 (DK43_00750) cls 140264..141796 (+) 1533 WP_003027762.1 cardiolipin synthase -
  DK43_RS10625 - 141860..141994 (+) 135 WP_003027761.1 hypothetical protein -
  DK43_RS00725 (DK43_00760) - 142049..143590 (+) 1542 WP_003027759.1 hypothetical protein -
  DK43_RS00730 (DK43_00765) nrdD 143698..145908 (+) 2211 WP_022525211.1 anaerobic ribonucleoside-triphosphate reductase -
  DK43_RS10395 (DK43_00770) - 145917..146057 (+) 141 WP_003027756.1 hypothetical protein -
  DK43_RS00735 (DK43_00775) - 146117..146614 (+) 498 WP_003027754.1 GNAT family N-acetyltransferase -
  DK43_RS00740 (DK43_00780) - 146624..147127 (+) 504 WP_003027752.1 GNAT family N-acetyltransferase -
  DK43_RS00745 (DK43_00785) nrdG 147132..147737 (+) 606 WP_003027750.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  DK43_RS00750 (DK43_00790) - 148085..149536 (+) 1452 WP_022525210.1 LCP family protein -
  DK43_RS00755 (DK43_00795) cps4B 149539..150270 (+) 732 WP_022525209.1 capsular polysaccharide biosynthesis protein Cps4B -
  DK43_RS00760 (DK43_00800) - 150279..150974 (+) 696 WP_041331419.1 Wzz/FepE/Etk N-terminal domain-containing protein -
  DK43_RS00765 (DK43_00805) - 150987..151682 (+) 696 WP_003026604.1 tyrosine-protein kinase -
  DK43_RS00770 (DK43_00810) - 151705..153078 (+) 1374 WP_003027744.1 sugar transferase -
  DK43_RS00775 (DK43_00815) - 153116..154297 (+) 1182 WP_022525207.1 beta 1-4 rhamnosyltransferase Cps2T -
  DK43_RS00780 (DK43_00820) - 154294..155208 (+) 915 WP_003027742.1 glycosyltransferase -
  DK43_RS00785 (DK43_00825) - 155232..156518 (+) 1287 WP_003027741.1 O-antigen polymerase -
  DK43_RS00790 (DK43_00830) - 156535..157701 (+) 1167 WP_022525206.1 glycosyltransferase family 4 protein -
  DK43_RS00795 (DK43_00835) - 157701..159149 (+) 1449 WP_003027739.1 flippase -
  DK43_RS00800 (DK43_00840) - 159167..160177 (+) 1011 WP_003027738.1 acyltransferase family protein -
  DK43_RS00805 (DK43_00845) - 160288..161244 (+) 957 WP_022525202.1 capsular polysaccharide synthesis protein -
  DK43_RS00810 (DK43_00850) - 161320..162141 (+) 822 WP_003027736.1 LicD family protein -
  DK43_RS00815 (DK43_00855) - 162171..162578 (+) 408 WP_003027735.1 serine acetyltransferase -
  DK43_RS00820 (DK43_00860) - 163079..164311 (-) 1233 WP_003027733.1 nucleotide sugar dehydrogenase -
  DK43_RS00825 (DK43_00865) - 164492..166366 (+) 1875 WP_022525201.1 NTP transferase domain-containing protein -

Sequence

Protein


Download         Length: 422 a.a.        Molecular weight: 45742.26 Da        Isoelectric Point: 6.5228

>NTDB_id=121187 DK43_RS00670 WP_022525214.1 132544..133812(+) (cinA) [Streptococcus anginosus strain SA1]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLASLGVDVYFQTAVGDNEARLLSILEIARNRSNLIILTGGLGPTEDDLTKQT
LSKFLNRRLVFDRMATEKLDRFFASRPDYVRTPNNERQAQIVEGSTSLQNETGLAVGGVIEVSGVTYVVLPGPPSELKPM
VNNELVPLLATGQKLYSRVLRFFGIGESQLVTLLGDLIDTQTDPTIAPYAKTGEVTLRLSTKATSQKEADVKFTRLEKKI
LAVQTFEKQHLADLFYAYGDDNSLGQTAFELLRRAGKTVTAAESLTAGLFQATLANFAGASNVFSGGFVTYSMEEKSRML
GIPLADLEKHGVVSAFTAEKMAEQARKLTASDYAVSLTGVAGPDSLEGHPAGTVYIGLATTEDVQSIKVNIAGRSRTDVR
KIAVLHAFNLLRKTLSKNENML

Nucleotide


Download         Length: 1269 bp        

>NTDB_id=121187 DK43_RS00670 WP_022525214.1 132544..133812(+) (cinA) [Streptococcus anginosus strain SA1]
ATGAAAGCAGAAATTATTGCTGTGGGTACTGAAATTCTGACAGGTCAAATTGTCAATACAAACGCCCAATTTTTATCTGA
AAAATTAGCGAGTCTGGGAGTAGATGTGTATTTCCAAACAGCGGTCGGAGATAATGAAGCTCGTCTGTTATCCATTTTAG
AAATCGCTCGAAATCGTAGTAATTTGATCATCTTAACTGGAGGATTAGGTCCAACAGAAGATGACTTGACTAAGCAGACT
TTGTCAAAATTCTTAAATCGTAGGTTGGTATTTGACCGAATGGCTACGGAGAAATTGGATCGCTTCTTCGCAAGTCGACC
GGACTATGTGCGAACACCCAATAATGAGCGACAAGCTCAGATAGTGGAAGGCTCGACCTCTCTCCAAAACGAAACCGGAC
TTGCAGTGGGGGGCGTGATTGAAGTCAGTGGGGTGACTTATGTCGTTCTGCCTGGACCGCCTAGTGAATTAAAACCTATG
GTAAATAATGAGCTGGTTCCGCTCTTAGCAACTGGTCAAAAATTGTATTCAAGAGTTTTGCGTTTCTTTGGTATTGGTGA
AAGTCAATTAGTAACCCTTTTAGGGGATTTAATTGATACTCAAACGGATCCGACCATTGCTCCTTATGCTAAGACGGGAG
AAGTAACTTTGCGATTGTCCACCAAGGCTACTAGTCAAAAGGAAGCGGATGTTAAGTTTACTCGTTTAGAAAAGAAAATT
TTAGCAGTACAAACTTTTGAGAAACAACATTTAGCTGATCTTTTCTACGCTTATGGAGATGATAATTCTCTGGGACAAAC
AGCTTTTGAACTGCTGAGAAGAGCAGGAAAGACCGTCACAGCAGCTGAAAGTTTGACTGCAGGACTTTTTCAAGCAACTT
TAGCAAACTTTGCTGGTGCCTCCAATGTTTTTAGTGGTGGCTTTGTTACCTACAGTATGGAGGAAAAGAGCCGAATGCTG
GGCATTCCCTTGGCAGACTTGGAAAAGCATGGGGTGGTTTCAGCTTTTACAGCAGAGAAAATGGCTGAGCAGGCAAGAAA
ATTGACCGCTAGTGACTATGCGGTGAGCTTGACAGGTGTGGCAGGTCCAGATAGCTTAGAAGGACATCCAGCAGGGACAG
TTTATATCGGCTTAGCAACCACAGAGGATGTTCAGTCTATTAAGGTTAATATTGCGGGTCGCAGTCGGACAGATGTACGT
AAAATAGCCGTTCTGCATGCTTTCAATCTGCTGCGAAAAACTTTATCAAAAAACGAAAATATGCTATAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Competence-damaged protein (CinA)

(263-415)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mitis SK321

76.145

98.341

0.749
  cinA Streptococcus mitis NCTC 12261

75.181

98.341

0.739
  cinA Streptococcus pneumoniae Rx1

74.94

98.341

0.737
  cinA Streptococcus pneumoniae R6

74.94

98.341

0.737
  cinA Streptococcus pneumoniae TIGR4

74.94

98.341

0.737
  cinA Streptococcus pneumoniae D39

74.699

98.341

0.735
  cinA Streptococcus mutans UA159

72.577

100

0.727
  cinA Streptococcus suis isolate S10

56.01

98.578

0.552
  cinA Bacillus subtilis subsp. subtilis str. 168

45.714

99.526

0.455

Multiple sequence alignment