Detailed information NTG1170437

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: ACLV7W_RS03830
• Genome accession: NZ_OZ217346
• Coordinates: 780301..780939 (+)
• Length: 212 a.a.
• NCBI ID: WP_411865462.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis D22
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 775301..785939

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7W_RS03800 (SMID22_07780)	frr	775548..776105 (+)	558	WP_001262225.1	ribosome recycling factor	-
ACLV7W_RS03805 (SMID22_07790)	cvfB	776166..777020 (+)	855	WP_001095459.1	RNA-binding virulence regulatory protein CvfB	-
ACLV7W_RS03810 (SMID22_07800)	-	777029..777244 (+)	216	WP_001232084.1	YozE family protein	-
ACLV7W_RS03815 (SMID22_07810)	-	777329..778324 (+)	996	WP_411865459.1	PhoH family protein	-
ACLV7W_RS03820 (SMID22_07820)	ald	778381..779493 (-)	1113	WP_411865460.1	alanine dehydrogenase	-
ACLV7W_RS03825 (SMID22_07830)	-	779665..780234 (+)	570	WP_411865461.1	GNAT family N-acetyltransferase	-
ACLV7W_RS03830 (SMID22_07840)	comEA/celA/cilE	780301..780939 (+)	639	WP_411865462.1	helix-hairpin-helix domain-containing protein	Machinery gene
ACLV7W_RS03835 (SMID22_07850)	comEC/celB	780923..783163 (+)	2241	WP_411865463.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
ACLV7W_RS03840 (SMID22_07870)	infC	783383..783913 (+)	531	WP_000848180.1	translation initiation factor IF-3	-
ACLV7W_RS03845 (SMID22_07880)	rpmI	783946..784146 (+)	201	WP_001125943.1	50S ribosomal protein L35	-
ACLV7W_RS03850 (SMID22_07890)	rplT	784198..784557 (+)	360	WP_000124834.1	50S ribosomal protein L20	-
ACLV7W_RS03855 (SMID22_07900)	-	784616..784996 (+)	381	WP_000157153.1	VOC family protein	-

Sequence

Protein

• Length: 212 a.a.
• Molecular weight: 22642.79 Da
• Isoelectric Point: 5.5031

>NTDB_id=1170437 ACLV7W_RS03830 WP_411865462.1 780301..780939(+) (comEA/celA/cilE) [Streptococcus mitis isolate S. mitis D22]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTAVKETNLQAEVAAVSKDSSTEKEEKEEPVEQDLITVDVKGAVKA
PGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAASQQTGSGTASSTSKEKKVNLNKASLEE
LKQVKGLGGKRAQDIIDHRESNGKFKSVDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide

• Length: 639 bp

>NTDB_id=1170437 ACLV7W_RS03830 WP_411865462.1 780301..780939(+) (comEA/celA/cilE) [Streptococcus mitis isolate S. mitis D22]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATTGTCATCTGTACTGGTCTGGGCTTACTTGTCGGCGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACAGCTGTCAAGGAAACGAATTTGCAGGCAGAAGTTGCAGCTGTTTCCAAGGATT
CATCGACCGAAAAGGAAGAAAAGGAAGAACCTGTTGAACAAGATCTAATCACAGTAGATGTAAAAGGCGCTGTTAAAGCA
CCTGGGATTTATGACTTGCCAGTAGGTAGTCGTGTCAATGATGCTGTTCAAAAGGCGGGTGGCTTGACAGAGCAAGCAGA
CAGCAAATCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCAACTAAGGGAGAGGAAGCAGCTA
GTCAACAGACTGGTTCTGGAACGGCTTCTTCAACGAGTAAGGAAAAGAAGGTCAATCTCAACAAGGCCAGTCTGGAAGAG
CTCAAGCAGGTCAAGGGTCTGGGTGGCAAACGAGCTCAGGATATTATCGACCATCGTGAATCAAATGGGAAATTCAAGTC
GGTTGATGAACTTAAGAAGGTTTCTGGTATTGGTGCTAAAACCATAGAAAAGCTAAAAGACTATGTTACAGTGGATTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (72-122)

• Helix-hairpin-helix motif (HHH_3) (147-210)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	95.37	100	0.972
comEA/celA/cilE	Streptococcus mitis NCTC 12261	93.056	100	0.948
comEA/celA/cilE	Streptococcus pneumoniae Rx1	92.593	100	0.943
comEA/celA/cilE	Streptococcus pneumoniae D39	92.593	100	0.943
comEA/celA/cilE	Streptococcus pneumoniae R6	92.593	100	0.943
comEA/celA/cilE	Streptococcus mitis SK321	89.352	100	0.91
comEA	Lactococcus lactis subsp. cremoris KW2	42.081	100	0.439
comEA	Streptococcus thermophilus LMD-9	40.175	100	0.434
comEA	Latilactobacillus sakei subsp. sakei 23K	34.061	100	0.368