Detailed information NTG1170438

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: ACLV7W_RS03835
• Genome accession: NZ_OZ217346
• Coordinates: 780923..783163 (+)
• Length: 746 a.a.
• NCBI ID: WP_411865463.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis D22
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 775923..788163

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7W_RS03805 (SMID22_07790)	cvfB	776166..777020 (+)	855	WP_001095459.1	RNA-binding virulence regulatory protein CvfB	-
ACLV7W_RS03810 (SMID22_07800)	-	777029..777244 (+)	216	WP_001232084.1	YozE family protein	-
ACLV7W_RS03815 (SMID22_07810)	-	777329..778324 (+)	996	WP_411865459.1	PhoH family protein	-
ACLV7W_RS03820 (SMID22_07820)	ald	778381..779493 (-)	1113	WP_411865460.1	alanine dehydrogenase	-
ACLV7W_RS03825 (SMID22_07830)	-	779665..780234 (+)	570	WP_411865461.1	GNAT family N-acetyltransferase	-
ACLV7W_RS03830 (SMID22_07840)	comEA/celA/cilE	780301..780939 (+)	639	WP_411865462.1	helix-hairpin-helix domain-containing protein	Machinery gene
ACLV7W_RS03835 (SMID22_07850)	comEC/celB	780923..783163 (+)	2241	WP_411865463.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
ACLV7W_RS03840 (SMID22_07870)	infC	783383..783913 (+)	531	WP_000848180.1	translation initiation factor IF-3	-
ACLV7W_RS03845 (SMID22_07880)	rpmI	783946..784146 (+)	201	WP_001125943.1	50S ribosomal protein L35	-
ACLV7W_RS03850 (SMID22_07890)	rplT	784198..784557 (+)	360	WP_000124834.1	50S ribosomal protein L20	-
ACLV7W_RS03855 (SMID22_07900)	-	784616..784996 (+)	381	WP_000157153.1	VOC family protein	-
ACLV7W_RS03860 (SMID22_07910)	-	785245..786045 (+)	801	WP_060628467.1	dihydroorotate dehydrogenase electron transfer subunit	-
ACLV7W_RS03865 (SMID22_07920)	-	786008..786994 (+)	987	WP_411865464.1	dihydroorotate dehydrogenase	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84600.91 Da
• Isoelectric Point: 9.3655

>NTDB_id=1170438 ACLV7W_RS03835 WP_411865463.1 780923..783163(+) (comEC/celB) [Streptococcus mitis isolate S. mitis D22]
MLQWIKNFPIPLIYLSFLLLWLYYAIFSASYIALLGFVFLLVCLFIQFPWKSAGKVLVLCVIFGFWFVFQTWQQSQASQN
LADSVERVRILPDTVKVNGDSLSFRGKSDGRIFQVYYKLQSEEEKEAFQVLTDLHEIELEGKLSEPEGQRNFGGFDYQAY
LKTQGIYQTLNIKKIQSLQKVGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMDGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGYKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVARESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLVLLPLLSI
LFALSFLYPVTQLNFMFEWLESIIRLVSQVARRPLVFGQPNAWLLILLLISLALVYDLRKNIKRVAGFSLLIVGLFFLIK
HPLENEITMLDAGQGESLFLRDVTGKTILIDVGGKAESDKKIEKWQEKATTSNAQRTLIPYLKSRGVAKIDQLVLTNTDK
EHVGDLLEVTKAFHVGEILVSKGSMKQKEFVAELQATQTKVRSVTVGENLQIFGSQLEVLSPRKIGDGSHEDSLVLYGKL
LDKHFLFTGNLDEKGEKDVLKHYPDLKVDVLKAGQHGSKKSTNSVFLEQLKPEITLISVGKNNRTKFPHQETLTRLEGIN
SKVYRTDQHGAIRFKGWNSWKIETVG

Nucleotide

• Length: 2241 bp

>NTDB_id=1170438 ACLV7W_RS03835 WP_411865463.1 780923..783163(+) (comEC/celB) [Streptococcus mitis isolate S. mitis D22]
ATGTTACAGTGGATTAAGAATTTCCCTATTCCCCTAATCTATCTGAGTTTTCTATTGCTCTGGCTTTACTACGCCATTTT
CTCAGCATCCTATATCGCACTGTTAGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCATGGAAATCTGCTG
GAAAAGTTCTAGTGCTTTGTGTAATTTTTGGATTCTGGTTTGTTTTTCAAACTTGGCAACAGAGTCAAGCTAGTCAAAAT
CTGGCGGATTCTGTTGAGAGGGTACGGATTTTGCCTGACACTGTTAAGGTCAATGGAGATAGCCTATCTTTTCGTGGTAA
GTCTGATGGACGCATTTTTCAAGTCTATTACAAGCTTCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGTCTTAACAGACC
TTCATGAGATAGAACTTGAAGGAAAACTTTCGGAGCCAGAAGGGCAGAGGAATTTTGGTGGATTTGACTATCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAAAAATCCAGTCACTTCAAAAGGTTGGCAGTTGGGATATAGG
AGAAAATCTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACACATTTTCCAGACCCTATGCGCAACTACATGA
CGGGTCTCTTGCTGGGACATCTGGACACCGACTTCGAGGAGATGAATGAGCTTTATTCTAGTCTAGGAATTATCCACCTC
TTTGCCTTGTCAGGTATGCAGGTAGGCTTTTTCATGGATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCAGGACTGACAGGATTTTCAGCATCGGTCATTCGAAGTC
TTTTGCAAAAATTATTGGCTCAACATGGCTATAAGGGCTTGGATAATTTTGCCCTGACTGTGCTTGTTCTCTTTATTGTC
ATGCCCAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGTGCTTATGCTTTTATCTTGACCATGACCAGCAAAGAAGG
CGAGGGGCTCAAGGCTGTTGCTAGAGAAAGTCTTGTCATTTCTTTGGGTATATTACCCATTTTATCCTTCTATTTTGCAG
AATTTCAACCATGGTCCATCCTTTTGACCTTTGTCTTTTCCTTCCTATTTGACTTGGTCCTCTTACCTCTCTTGTCTATC
TTATTTGCCCTTTCCTTTCTCTATCCAGTCACTCAACTTAATTTTATGTTTGAATGGTTGGAAAGCATTATTCGCTTGGT
ATCACAGGTGGCACGTAGGCCTCTGGTCTTTGGACAACCCAATGCATGGCTGTTGATACTACTATTAATTTCTTTGGCTT
TGGTCTATGATTTGAGGAAAAATATCAAAAGAGTAGCTGGATTCAGCTTACTTATTGTGGGTCTCTTTTTCTTGATCAAG
CATCCACTGGAAAATGAAATCACTATGCTGGATGCGGGGCAAGGCGAGAGTCTTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTGGGCGGTAAGGCAGAATCTGATAAGAAAATAGAAAAATGGCAAGAAAAGGCGACGACCAGTAATG
CCCAGCGAACCTTGATTCCTTATCTAAAAAGTAGAGGAGTAGCCAAGATTGACCAGCTAGTTTTGACAAATACGGACAAG
GAGCATGTTGGAGACTTGTTGGAGGTGACCAAGGCTTTTCATGTAGGCGAAATTTTAGTGTCAAAAGGCAGTATGAAACA
GAAGGAATTTGTGGCAGAACTACAGGCGACTCAAACCAAGGTGCGTAGTGTGACAGTAGGAGAGAACTTGCAAATTTTTG
GAAGTCAGTTAGAAGTTCTATCTCCAAGGAAAATTGGAGATGGGAGTCATGAAGATTCCCTAGTTCTGTATGGAAAACTC
TTGGATAAGCACTTTCTTTTCACTGGAAACTTGGATGAGAAAGGAGAGAAGGACGTGCTGAAGCATTATCCAGACTTGAA
AGTGGATGTTTTGAAAGCTGGCCAACATGGCTCCAAAAAATCAACAAATTCAGTTTTCTTAGAACAGCTCAAACCAGAGA
TTACTCTCATCTCAGTTGGAAAGAACAATCGAACGAAATTCCCCCATCAGGAAACCTTGACACGACTGGAAGGTATCAAT
AGTAAAGTTTATCGAACTGACCAGCATGGAGCTATCAGGTTTAAAGGGTGGAATAGTTGGAAGATTGAAACGGTTGGGTA
A

Domains

Predicted by InterproScan.

• Metallo-beta-lactamase superfamily (Lactamase_B) (493-700)

• Domain of unknown function (DUF4131) (DUF4131) (31-177)

• Competence protein (Competence) (216-458)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis NCTC 12261	92.091	100	0.921
comEC/celB	Streptococcus mitis SK321	91.946	99.866	0.918
comEC/celB	Streptococcus pneumoniae TIGR4	90.738	99.866	0.906
comEC/celB	Streptococcus pneumoniae Rx1	90.336	99.866	0.902
comEC/celB	Streptococcus pneumoniae D39	90.336	99.866	0.902
comEC/celB	Streptococcus pneumoniae R6	90.336	99.866	0.902
comEC	Lactococcus lactis subsp. cremoris KW2	43.607	99.598	0.434