Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   QML67_RS00485 Genome accession   NZ_OX346401
Coordinates   94262..95509 (+) Length   415 a.a.
NCBI ID   WP_171378695.1    Uniprot ID   -
Organism   Enterococcus cecorum isolate CIRMBP-1246     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 87457..133646 94262..95509 within 0
IS/Tn 93336..94154 94262..95509 flank 108


Gene organization within MGE regions


Location: 87457..133646
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QML67_RS00455 (CIRMBP1246_00084) - 87715..89004 (+) 1290 WP_171378697.1 pitrilysin family protein -
  QML67_RS00460 (CIRMBP1246_00085) - 89112..89837 (+) 726 WP_087663263.1 ABC transporter ATP-binding protein -
  QML67_RS00465 (CIRMBP1246_00086) - 89834..90910 (+) 1077 WP_171332615.1 ABC transporter permease -
  QML67_RS00470 (CIRMBP1246_00087) - 91030..91968 (+) 939 WP_171378696.1 helix-turn-helix domain-containing protein -
  QML67_RS00475 (CIRMBP1246_00088) pgsA 92079..92657 (+) 579 WP_087213988.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  QML67_RS00480 - 92734..94154 (+) 1421 WP_281957438.1 IS3 family transposase -
  QML67_RS00485 (CIRMBP1246_00091) cinA 94262..95509 (+) 1248 WP_171378695.1 competence/damage-inducible protein A Machinery gene
  QML67_RS00490 (CIRMBP1246_00092) recA 95633..96688 (+) 1056 WP_171378694.1 recombinase RecA Machinery gene
  QML67_RS00495 (CIRMBP1246_00093) rny 96907..98466 (+) 1560 WP_087213930.1 ribonuclease Y -
  QML67_RS00500 (CIRMBP1246_00094) - 98683..98904 (+) 222 WP_016250396.1 helix-turn-helix transcriptional regulator -
  QML67_RS00505 (CIRMBP1246_00095) - 98891..99652 (+) 762 WP_281957439.1 DUF3169 family protein -
  QML67_RS00510 (CIRMBP1246_00096) - 99681..100580 (+) 900 WP_087213928.1 ABC transporter ATP-binding protein -
  QML67_RS00515 (CIRMBP1246_00097) - 100573..101835 (+) 1263 WP_171378691.1 ABC transporter permease -
  QML67_RS00520 - 102070..102210 (+) 141 WP_281957441.1 hypothetical protein -
  QML67_RS00525 (CIRMBP1246_00099) - 102255..103094 (-) 840 WP_171378690.1 Cof-type HAD-IIB family hydrolase -
  QML67_RS00530 (CIRMBP1246_00100) gor 103335..104681 (+) 1347 WP_281957726.1 glutathione-disulfide reductase -
  QML67_RS00535 (CIRMBP1246_00101) - 105057..105968 (+) 912 WP_016250387.1 LysR family transcriptional regulator -
  QML67_RS00540 (CIRMBP1246_00102) - 106703..108145 (+) 1443 WP_087213923.1 cytochrome ubiquinol oxidase subunit I -
  QML67_RS00545 (CIRMBP1246_00103) cydB 108138..109154 (+) 1017 WP_168930902.1 cytochrome d ubiquinol oxidase subunit II -
  QML67_RS00550 (CIRMBP1246_00104) cydD 109151..110872 (+) 1722 WP_281957442.1 thiol reductant ABC exporter subunit CydD -
  QML67_RS00555 (CIRMBP1246_00105) cydC 110865..112619 (+) 1755 WP_281957443.1 thiol reductant ABC exporter subunit CydC -
  QML67_RS00560 (CIRMBP1246_00106) - 113526..114989 (+) 1464 WP_087213919.1 peptide MFS transporter -
  QML67_RS00565 (CIRMBP1246_00107) - 115216..115818 (+) 603 WP_087213918.1 histidine phosphatase family protein -
  QML67_RS00570 (CIRMBP1246_00108) - 115872..117863 (-) 1992 WP_171378688.1 KUP/HAK/KT family potassium transporter -
  QML67_RS00575 (CIRMBP1246_00109) - 118101..118679 (+) 579 WP_171301859.1 uracil-DNA glycosylase family protein -
  QML67_RS00580 (CIRMBP1246_00110) - 118723..119448 (-) 726 WP_171378687.1 DUF554 domain-containing protein -
  QML67_RS00585 (CIRMBP1246_00111) glf 119642..120745 (-) 1104 WP_171378686.1 UDP-galactopyranose mutase -
  QML67_RS00590 (CIRMBP1246_00112) - 120926..121759 (+) 834 WP_087213905.1 VOC family protein -
  QML67_RS00595 (CIRMBP1246_00113) - 122000..122410 (+) 411 WP_047333989.1 hypothetical protein -
  QML67_RS00600 (CIRMBP1246_00114) - 122432..123859 (+) 1428 WP_087213904.1 SPFH domain-containing protein -
  QML67_RS00605 (CIRMBP1246_00115) - 123862..124173 (+) 312 WP_047241695.1 heavy metal-binding domain-containing protein -
  QML67_RS00610 (CIRMBP1246_00116) - 124408..124758 (+) 351 WP_087213903.1 bacteriocin immunity protein -
  QML67_RS00615 (CIRMBP1246_00117) - 125088..126683 (+) 1596 WP_171378713.1 alpha-glucoside-specific PTS transporter subunit IIBC -
  QML67_RS00620 (CIRMBP1246_00118) - 126711..128042 (+) 1332 WP_171378714.1 6-phospho-alpha-glucosidase -
  QML67_RS00625 (CIRMBP1246_00119) - 128110..128874 (+) 765 WP_281957444.1 MurR/RpiR family transcriptional regulator -
  QML67_RS00630 (CIRMBP1246_00120) - 128880..129311 (+) 432 WP_171378716.1 hypothetical protein -
  QML67_RS00635 (CIRMBP1246_00121) - 129485..129943 (+) 459 WP_047241691.1 hypothetical protein -
  QML67_RS00640 (CIRMBP1246_00122) - 129957..130727 (+) 771 WP_171378717.1 DUF6681 family protein -
  QML67_RS00645 (CIRMBP1246_00123) - 130770..131081 (+) 312 WP_171378718.1 hypothetical protein -

Sequence

Protein


Download         Length: 415 a.a.        Molecular weight: 45538.92 Da        Isoelectric Point: 4.8446

>NTDB_id=1154894 QML67_RS00485 WP_171378695.1 94262..95509(+) (cinA) [Enterococcus cecorum isolate CIRMBP-1246]
MNAEIIAVGTEILMGQIVNSNAAYLSEQLANLGINVYYHVAVGDNEKRLTACLERAKSRSDLIVLCGGLGPTQDDLTKQT
VAKFVNQELVYDPTGHARLMDYFAKTKREMTENNLLQALTFKDGRGIANPNGLAVGIYYEDSDYTHYLLLPGPPRELKAM
FRQNVVPLLREINPQDTKLYSRVLRFYGIGESQLVTLLADFIDHQTNPTLAPYAKTNEVTLRLTANASTQDQADRLLDEL
EEKIQALAGAYFYGYGDDFSLAEAMIAQLKEQKRTISVAESLTAGLFASTLGQYPGVSQVFKGGVVTYSLEMKAALLDID
ADYLREVGTVSEACVTLMAKNMQQKAQTDYAIAFSGVAGPDQLEGQAVGTVWMALATPNGVQTCCKQFPHGRNEIRQAAV
MFGLNLVYRALLAEA

Nucleotide


Download         Length: 1248 bp        

>NTDB_id=1154894 QML67_RS00485 WP_171378695.1 94262..95509(+) (cinA) [Enterococcus cecorum isolate CIRMBP-1246]
ATGAATGCAGAAATCATTGCAGTCGGAACAGAGATTTTGATGGGGCAAATCGTTAATTCTAACGCGGCCTATCTTTCAGA
GCAATTAGCCAATTTGGGGATTAATGTTTATTATCATGTCGCAGTCGGAGATAATGAAAAGCGATTGACGGCCTGTCTTG
AACGTGCCAAAAGTCGGAGTGATTTAATCGTGCTTTGTGGTGGTTTGGGGCCTACGCAAGATGATTTAACCAAGCAAACT
GTAGCCAAATTTGTCAATCAAGAATTAGTCTATGATCCAACAGGGCATGCACGTTTGATGGATTATTTTGCCAAGACCAA
GCGAGAAATGACCGAAAATAATTTATTACAAGCCCTCACTTTTAAGGATGGTCGTGGTATTGCCAATCCAAATGGTCTAG
CGGTCGGTATTTATTATGAAGATAGCGATTATACTCACTATTTATTATTACCTGGGCCACCGCGCGAGTTAAAGGCGATG
TTTCGTCAAAATGTTGTGCCACTTTTGCGTGAAATCAATCCGCAAGATACGAAGCTCTATTCTCGGGTGTTGCGTTTTTA
TGGTATTGGCGAATCGCAGTTAGTCACGCTTTTAGCGGATTTCATTGACCATCAGACCAACCCTACGCTAGCTCCCTATG
CCAAAACCAATGAAGTGACGTTGCGTTTGACAGCCAATGCATCTACCCAAGATCAAGCGGATAGGTTGCTTGATGAATTA
GAGGAGAAAATTCAAGCTTTGGCCGGTGCTTACTTTTATGGTTATGGGGATGATTTTTCTTTAGCGGAGGCGATGATTGC
CCAATTAAAAGAGCAAAAACGGACAATCAGTGTGGCTGAGAGTTTGACAGCCGGCCTTTTTGCTTCCACCTTGGGACAAT
ATCCGGGGGTGTCACAGGTCTTTAAAGGTGGTGTGGTCACTTATTCCCTTGAGATGAAGGCGGCTTTATTAGATATTGAT
GCCGATTATTTACGAGAAGTCGGTACGGTGAGTGAAGCTTGTGTCACCTTAATGGCTAAAAATATGCAGCAAAAAGCGCA
AACGGATTATGCCATTGCTTTTAGTGGTGTGGCGGGACCGGATCAATTAGAAGGCCAAGCAGTCGGAACTGTCTGGATGG
CTTTGGCGACTCCAAATGGGGTACAGACCTGTTGCAAACAGTTCCCCCATGGCCGCAATGAAATCCGCCAAGCCGCTGTC
ATGTTTGGGTTAAATCTCGTTTATCGCGCGCTTTTAGCGGAAGCATAG

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(260-410)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(181-254)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae TIGR4

51.537

100

0.525
  cinA Streptococcus pneumoniae Rx1

51.3

100

0.523
  cinA Streptococcus pneumoniae R6

51.3

100

0.523
  cinA Streptococcus mitis SK321

51.3

100

0.523
  cinA Streptococcus pneumoniae D39

51.064

100

0.52
  cinA Streptococcus mutans UA159

51.435

100

0.518
  cinA Streptococcus mitis NCTC 12261

50.591

100

0.516
  cinA Streptococcus suis isolate S10

47.532

92.771

0.441
  cinA Bacillus subtilis subsp. subtilis str. 168

44.39

98.795

0.439

Multiple sequence alignment