Detailed information NTG1154370

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: AD178_RS11050
• Genome accession: NZ_OX244288
• Coordinates: 2141879..2142631 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PT8105 isolate 2RLC4
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2136879..2147631

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AD178_RS11030	-	2139313..2140987 (-)	1675	Protein_2144	YhgE/Pip domain-containing protein	-
AD178_RS11035 (SAMEA1463109_02228)	-	2141094..2141636 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
AD178_RS11050 (SAMEA1463109_02231)	comE	2141879..2142631 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
AD178_RS11055 (SAMEA1463109_02232)	comD/comD2	2142628..2143953 (-)	1326	WP_000364845.1	competence system sensor histidine kinase ComD	Regulator
AD178_RS11060 (SAMEA1463109_02233)	comC/comC2	2143974..2144099 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
AD178_RS11070 (SAMEA1463109_02235)	rlmH	2144381..2144860 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
AD178_RS11075 (SAMEA1463109_02236)	htrA	2145043..2146224 (+)	1182	WP_000681590.1	trypsin-like peptidase domain-containing protein	Regulator
AD178_RS11080 (SAMEA1463109_02237)	spo0J	2146282..2147040 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=1154370 AD178_RS11050 WP_000866065.1 2141879..2142631(-) (comE) [Streptococcus pneumoniae strain PT8105 isolate 2RLC4]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=1154370 AD178_RS11050 WP_000866065.1 2141879..2142631(-) (comE) [Streptococcus pneumoniae strain PT8105 isolate 2RLC4]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGTAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408